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Clinical Trials in Los Angeles, California

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Los Angeles, California

Los Angeles, the "City of Angels" is California's largest city and is second only to New York in population. It is known for the Hollywood entertainment industry, mild climate, bumper-to-bumper traffic, ethnic diversity and considerable leisure and outdoor opportunities. When it comes to health care, this sprawling metropolis has more than 25 hospitals with scores more in the surrounding Los Angeles county. So, there is no shortage facilities for Angelenos to receive general medical services, emergency and acute care, and specialty health care.

Below are some of the best hospitals in the city of Los Angeles, according to U.S. News and World Report. The media company's Best Hospitals rankings helps consumers make decisions about where to find inpatient hospital care in their community and beyond. Los Angeles clinical trials can be found at almost all of them.

UCLA Health

For more than 30 years, the UCLA Health system has been ranked among the country's best in U.S News and World Report's annual review. Within the LA city limits, three UCLA hospitals reside on the UCLA Health main campus in the Westwood section of the city. Ronald Reagan UCLA Medical Center, UCLA Mattel Children's Hospital and UCLA Resnick Neuropsychiatric Hospital:

Ronald Reagan UCLA Medical Center

With more than 1,500 doctors on staff, Ronald Reagan UCLA Medical Center cares for more than 300,000 people a year from greater Los Angeles, California and around the world. It is a general medical and surgical hospital, level one trauma center and teaching facility. US News and World Report has ranked it as the 4th best hospital in the U.S. and first on the West Coast.

UCLA Mattel Children's Hospital

Located on distinct floors of the Ronald Reagan UCLA Medical Center, UCLA Mattel Children's Hospital attracts pediatric patients from all over California. Physicians provide the full range of general and specialty care to infants, children, adolescents, and young adults up to age 21. The hospital has ranked nationally in all pediatric specialties reviewed by U.S. News & World Report.

UCLA Resnick Neuropsychiatric Hospital

Residing on a floor of the Ronald Reagan UCLA Medical Center, UCLA Resnick Neuropsychiatric Hospital provides world-class patient care to adults and children in the areas of mental health, developmental disabilities, and neurology. The hospital's many programs include treatment for ADHD, eating disorders, anxiety, and sleep disorders.

Children's Hospital of Los Angeles

Children's Hospital of Los Angeles opened in 1901 in a small house in what is today's Chinatown. Over the years, it has grown to include more than 350 pediatric specialty programs and services. The hospital's Heart Institute has gained world-wide recognition for treatment of heart and lung disorders in children and has one of the busiest cardiac care programs in the nation. U.S. News and World Report has ranked this institution among the top five children's hospitals in the country.

Cedars-Sinai Medical Center

Often regarded as the hospital of Hollywood celebrities, Cedars-Sinai Hospital had humble beginnings in 1902 as a 12-bed hospital. Today, it is the largest non-profit hospital in the country with 4,500 physicians and nurses and nearly 900 beds. U.S. News and World Report has ranked Cedars Sinai #7 in its authoritative review of Best Hospitals. Boasting a robust medical research program, the hospital offers extensive array of clinical trials in Los Angeles. It has one of the largest, most advanced research facilities of any private hospital in the country.

Keck Hospital of USC

Keck Hospital of USC, east of downtown Los Angeles is an acute care hospital with just over 400 beds. Hundreds of clinical trials in LA taking place at Keck Hospital and its affiliated institutions, offering participants access to potential therapies that are not yet widely available. The hospital has ranked #18 nationally on U.S. News and World Report's Best Hospitals honor roll.

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Join a Clinical Research Trial

What are clinical trials and studies.

Clinical trials are part of clinical research and foundation of all medical advances. They are dedicated to exploring new and better ways for the prevention, detection, or treatment of various disease.

By participating in a clinical trial, you have the opportunity to contribute to the development of new treatments and help improve the lives of others. 

Learn more about our paid clinical trials in Los Angeles and Orange Country, California.

Who is Altasciences?

Altasciences is an internationally recognized clinical research organization based in Laval, Canada, with 9 facilities across Northern America, including our Cypress, California location. For more than 30 years, Altasciences has been able to conduct valuable clinical research, thanks to volunteers like you. 

At Altasciences, your safety and well-being are top priority, as we move in unison to advance research and life-saving therapeutics.

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What to expect in a clinical trial.

After registering for one of our clinical trials, you'll undergo screening tests to determine your eligibility. If you pass the screening, you'll be invited to participate. We offer a range of trials, from single outpatient visits to inpatient clinical trials, ensuring we have an option that suits you. 

Stay informed on the latest clinical trial news and insights with Altasciences LA's blog. 

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Begin your journey to better health and wellness through our paid clinical trials in the greater Los Angeles area.

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Sjogren’s Syndrome

Current clinical trials.

PARTICIPATING WITH MEDVIN, YOU MAY

Unlock the Potential of Medical Research

Paid clinical trials help you find relief through exciting medical advancements. Volunteering allows you to try new treatments, procedures, and devices you won’t find anywhere else. It's a safe and effective way to discover new healthcare options and feel better!

Be a Part of Something Bigger

At our medical research clinics in Los Angeles, patients have embarked on the same journey of hope and transformation. With your participation, finding answers is possible and helps millions of people with the chance of curing lifelong diseases in the future.

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With the support of our expert medical team, you can take charge of your well-being and embrace a brighter outlook. If you're looking for a medical setting where you feel valued and see results , we invite you to join one of our studies.

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THE HIGHEST-PAYING CLINICAL TRIALS YOU CAN PARTICIPATE IN

Discover top-paying clinical trials in your area. Our guide highlights the most common and accessible trials.

THE TOP 5 SKILLS EVERY CLINICAL RESEARCH ASSOCIATE OR COORDINATOR SHOULD HAVE

These five skills for top-performing CRAs or CRCs are a must for the success of new medical treatments.

THE IMPORTANCE OF CLINICAL RESEARCH IN ADVANCING MEDICINE

Make a difference and improve your health! Discover why paid clinical research studies are so important for medicine.

NEWS & ARTICLES: EXPLORE THE WORLD OF CLINICAL TRIALS

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WELCOME TO SANTA MONICA CLINICAL TRIALS

Santa Monica Clinical Trials is a private clinical research site located in Los Angeles, California. Our Investigators have over 20 years of experience and are engaged in numerous phase II-IV clinical research trials, including drug and medical device studies. Participation does not require proof of medical insurance. All trials are conducted under FDA guidance and regulations.

If you or a loved one suffers from one of these disorders, take the next step and contact a member of our study team today! No medical insurance needed. Compensation for time & travel may be available upon inquiry.

Current trials, prader-willi syndrome.

Prader-Willi Syndrome (PWS) is a congenital syndrome that affects many systems of the body. Common early signs of PWS include muscle weakness, feeding difficulties, and behavioral disturbances. Patients may also experience excessive daytime sleepiness (EDS), making it difficult to perform everyday activities and negatively affecting their mood. The purpose of this study is to evaluate the efficacy and safety of the study medication on daytime sleepiness in those with Prader-Willi Syndrome.

Narcolepsy is a chronic neurological disorder that affects the brain's ability to regulate sleep-wake cycles. Those with narcolepsy experience excessive daytime sleepiness despite feeling well-rested upon waking. Individuals might have frequent, uncontrollable bouts of sleep. Depending on the type of narcolepsy, symptoms may also include sudden muscle weakness causing patients to go limp. This study will explore the efficacy and safety of an oral study medication in promoting wakefulness in those with narcolepsy type 1 (NT1) or narcolepsy type 2 (NT2).

IDIOPATHIC HYPERSOMNIA

Idiopathic hypersomnia (IH) is a rare neurological disorder which is characterized primarily by excessive sleep and excessive daytime sleepiness. This study will look at safety and efficacy of the oral investigational drug in promoting wakefulness for those with idiopathic hypersomnia.

SLEEP APNEA

Obstructive Sleep Apnea (OSA) is a common and serious sleep disorder in which breathing is repeatedly interrupted during sleep. OSA occurs when the airway collapses as you breathe in. This can cause breathing to be paused from several seconds to over a minute. 

While many people use continuous positive airway pressure (CPAP) machines to manage their OSA, these systems can be cumbersome and awkward for some. The LunAIRo study involves an investigational oral medication for people who have OSA. The investigational medication will be taken daily at bedtime. 

SLEEP DISTURBANCES IN INDIVIDUALS WITH AUTISM SPECTRUM DISORDER

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is associated with persistent deficits in social communication, restricted/repetitive behaviors, among other symptoms. Sleep disruption in individuals with ASD is higher than in healthy controls with a documented prevalence of up to 80%. The purpose of this study is to evaluate the effectiveness and safety of the study medication on sleep in individuals with autism spectrum disorder.

MOTION SICKNESS

Motion sickness is a common condition affecting about 30% of the population. Common symptoms of motion sickness include nausea, vomiting, stomach awareness, pallor, headache, sweating, dizziness, a sensation of warmth and drowsiness. The purpose of the study is to evaluate the effectiveness of an investigational drug on symptoms associated with motion sickness and to assess the safety of the investigational drug.

DELAYED SLEEP-WAKE PHASE DISORDER

Delayed sleep–wake phase disorder (DSWPD) is a chronic dysregulation of a person's circadian rhythm (biological clock), compared to those of the general population and societal norms.  People with DSWPD generally fall asleep some hours after midnight and have difficulty waking up in the morning. However, they find it very difficult to wake up in time for a typical school or work day. If they are allowed to follow their own schedules, e.g. sleeping from 4:00 am to 1:00 pm, their sleep is improved and they may not experience excessive daytime sleepiness. The purpose of this study is to evaluate the efficacy and safety of an investigational medication compared to placebo for this condition.

ARE YOU ELIGIBLE?

If you’re interested in participating in one of our current or upcoming studies, please contact our office today to inquire about your candidacy.

Flourish Research – Los Angeles

Our nationally recognized clinical trial sites are dedicated to the development of life-changing therapeutics

Explore Flourish Research – Los Angeles

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Advancing The Health And Wellness Of Society Through Clinical Trials

Find a clinical trial near you.

Unsure about what is involved in a clinical trial? Our team is available to answer all your questions about treatments, tests, timelines, compensation, and more. Fill out a form for a study of interest and we will contact you or schedule a call at your convenience.

We Go The Extra Mile For Research

Participate in a clinical trial to learn more about your condition, advance medical discoveries, and receive access to new treatments and medications at no cost! Compensation is available for your time.

Benefits Of Participating

You may be compensated for your study participation.

Studies offer monetary compensation to study volunteers in return for time and travel during their participation.

You may receive diagnostic tests, ECGs, lab work, radiological tests, medical exams or genetic testing at no cost

Diagnostic tests are performed to ensure that the study is a good fit for you and are provided at no cost.

You may have access to doctors without having to wait months for an appointment

Before and during the study, you will meet with board-certified physicians and highly-trained and skilled research staff and receive one-on-one care.

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Participate in a clinical trial in your area to learn more about your condition, advance medical research, and receive access to new treatments and medications at no cost to you!

Exciting New s! ENCORE™  is now part of the Flourish family!

Los Angeles (Westlake), California

Velocity clinical research, westlake.

Velocity’s Westlake research site was founded as the National Research Institute, a five-site research network in southern California, and acquired by Velocity in 2021. Our Westlake site offers a wide range of expertise including diabetes, NASH, vaccines, psychiatry, women’s health, and pediatric trials. Westlake’s experienced staff maintains high quality standards and enrollment on all their trials.

Located outside of Los Angeles, the Westlake site is easily accessible for patients through public transport. The Westlake team is bilingual allowing the site to recruit a diverse patient population. The local hospital is located next door to the site. With more than 12,000 square-feet of dedicated research space, they can efficiently and effectively conduct multiple concurrent studies.

All trials conducted at the site are performed in accordance with ICH and FDA guidelines, and in compliance with GCP. The Westlake team is committed to being a resource for study participants, to providing the highest quality of patient care with compassion and kindness, and to advancing medicine through research.

Velocity Clinical Research, Westlake 2010 Wilshire Blvd, Suite 302, Los Angeles, CA 90057

Phone: (213) 483-1800

Se habla español.

Find a Clinical Trial in Los Angeles (Westlake) Use the dropdown to browse current studies in Los Angeles (Westlake).

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About Velocity Clinical Research

200,000+ people have a joined a study at Velocity

Many people enjoy the study experience and have joined several clinical trials at Velocity.

Velocity has decades of research experience

With sites that were established as long ago as 1986, Velocity has experts who have supported clinical trials for decades.

Velocity studies are led by healthcare professionals

All clinical trials conducted at Velocity are overseen by the U.S. Food and Drug Administration (FDA).

Our experienced research team in Los Angeles (Westlake)

Every clinical trial is overseen by a Principal Investigator – a physician who is responsible for the rights, safety and welfare of the study participants. All physicians at Velocity are board certified in their specialty area(s) and all research staff is trained in clinical research regulations, including GCP and HIPAA. Our clinical research team in Los Angeles (Westlake) is dedicated to conducting quality research in a professional and caring environment.

Mark Leibowitz, MD

Principal Investigator Mark Leibowitz, MD is an experienced and skilled Investigator with approximately 25 years of research experience. Dr. Leibowitz has participated in an estimated 500 studies from Phase I-IV across a variety of different indications. As part of his research portfolio, Dr. Leibowitz has conducted highly complex studies in healthy subjects and diverse patient populations including continuous cerebrospinal fluid studies, First in Human, Single and Multiple Ascending Dose studies, Ethnic bridging programs, QTc studies, as well as, serving as Principal Investigator for many adaptive trial designs. His experience includes leadership roles such as Medical Director for research sites located in California and Texas. In addition, he is currently a contributing member for a Data Safety Monitoring Board.

David Guzman, MD

Principal Investigator David Guzman, MD is an experienced board-certified Internist who joined Velocity Clinical Research in 2022. He completed his undergraduate studies at Massachusetts Institute of Technology (MIT) and received his medical degree from the University of Chicago, Pritzker School of Medicine. He completed his postgraduate training in Internal Medicine at Northwestern University McGaw Medical Center and remained there as an Instructor in Clinical Medicine. Dr. Guzman participated in Community Based Clinical Trials at a federally-qualified health center in Chicago from 1990 to 1993. He is a native Spanish speaker and has served various Latino communities in Chicago, south Florida, and now southern California with a focus on providing both primary care and urgent care.

John Nelson, PA-C

Principal Investigator John Nelson, PA-C is a skilled Physician Assistant with over 20 years of medical and clinical research experience in a variety of indications such as Pulmonary Medicine and Critical Care, Internal Medicine, Gastroenterology, Infectious Disease, Emergency Medicine, and Geriatrics. He obtained his Physician Assistant certification from the USC School of Medicine. John currently serves as a Sub-Investigator for multiple Velocity sites in the LA area and is a member of the California Academy of Physician Assistants.

Cheryll Handy, PA-C

Sub-Investigator Cheryll Handy, PA-C is a skilled Physician Assistant with over 27 years of medical and clinical research experience in a variety of indications such as Internal Medicine, Gastroenterology, Infectious Disease, Emergency Medicine, Urgent Care, Pediatrics, Endocrinology, Geriatrics and Workman’s Compensation. She obtained her Physician Assistant certification from the Charles R. Drew of Medicine and Science. PA Cheryll currently serves as a Sub-Investigator for Velocity sites in the LA area.

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The Remarkable History and Impact of HeLa Cells in Research 

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Learn more about participating in a clinical trial.

Liver disease is a growing concern across the globe, especially in the United States, where the prevalence of conditions like Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis … Read more

What is Informed Consent?

Joining a clinical trial is an important decision. Most participants come to the clinic with questions about clinical trials and what joining one could mean. This is why every study … Read more

Clinical Trial Phases: What Happens in Phase 1, 2, 3 and 4?

Clinical trials are research studies of medications, vaccines, medical devices, procedures, diagnostics (tests), and other health-related products. These studies involve participants (also known as patients, volunteers, or subjects) to determine … Read more

Participant Story: Maryann, a Research Study Participant at Velocity

What led you to participate in a research study? I saw a roadside poster near the university in my neighborhood [for a vaccine study] and called Velocity. My first experience … Read more

Complete the form to start your clinical trial journey in Los Angeles (Westlake)

Why join a clinical trial?

• Help advance medicine
• Learn about potential new medicines in development
• Get study-related medical exams at no cost
• Receive compensation for participating (available amounts may differ for each study)

After you submit your info, a Velocity staff member will review your info. They will contact you to talk about the study, or others that may be right for you.

Health insurance is generally not needed to join a clinical trial.

Remember, there is never an obligation to join — we're here to help you make the best decision.

Submit your info

By entering your email address and/or phone number on this form, you represent that you are at least 18 years of age and consent to receiving communications (e.g., call, SMS, text, and/or email) from Velocity and/or the research site(s) involved with the clinical trials that appear on this website. Message and data rates may apply. You may reply with STOP to a text message. For full details, refer to Velocity's privacy policy and website terms of use . Submissions on this website are not monitored 24/7. Do NOT submit personal health or medical information on this form. If you are enrolled in a trial and have questions, please call your research site.

Sponsors and CROs

From the leading pharma companies, to the most pioneering biotech startups, Velocity supports those who are exploring new frontiers in human health. Whether you’re ready to conduct a single-site study or a complex, high-volume clinical trial, trust Velocity.

It all starts with people like you.

Without clinical trial participants, it would not be possible to create new medicines, treatments, and cures..

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Call to join a study

The recognized leader in clinical trials resulting in new and better medicines.

Active studies, generalized anxiety study (gad).

Age 18-65 · Male / Female

Compensation TBD

Attention Deficit Hyperactivity Disor...

CenExel CNR is seeking volunteers living with ADHD to participate in our clinical trial.

Age 18-55 · Male / Female

Compensation up to $750

Free Memory Evaluation

Age 50+ · Male / Female

At Risk for Alzheimer’s Disease Study

Age 50-80 · Male / Female

Compensation up to $4,275

Social Anxiety Study

Compensation up to $1,125

Migraine Trials

Still struggling to manage migraines? Don't settle.

Age 18 and up · Male / Female

Compensation up to $1,725

Major Depression Trials

Compensation up to $1,000

Postpartum Depression Study

Age 18-45 · Female

Compensation up to $600

Memory Loss Study

Age 50-90 · Male / Female

Compensation up to $5,500

Don’t see what you’re looking for? Simply complete this  information form , and we’ll find a study that fits you.

Read about our COVID-19 safety precautions

Accelerate healthcare

Help in development of future medicines.

Your participation will be incredibly valuable in providing researchers with information to move forward, regardless of the outcome of the clinical trial.

Gain access to new medical treatments

California Neuroscience Research offers participants innovative medicines at the leading edge of pharmaceutical evolution.

Receive compensation for time & travel

While the financial benefits of participation typically won’t replace the need for a regular job, you will be paid for your time and travel expenses.

Clinical research provides first-class medical care

Every study at CenExel CNR is overseen by expert medical staff and one of the most well-respected, board-certified physicians in the clinical research industry.

25+ years of clinical trial experience

Trusted Partner For Clinical Trials in Los Angeles

Our mission, under the direction of our Principal Investigator, Dr. Felix Sigal , is to conduct clinical trials in Los Angeles with the highest level of scientific rigor and ethical standards to advance the development of safe and effective medical treatments. We strive to provide excellent patient care, to foster collaboration between healthcare providers, and to contribute to the body of medical knowledge through innovative research.

We strive to maintain open communication with our Sponsors , patients and the broader medical community to promote transparency and trust. The goal of Angel City Research is to contribute to the development of new treatments and therapies that will ultimately benefit patients worldwide through high-quality CRO clinical research.

Speciality in Areas of Research

We research treatments for all disorders suffered by diabetic patients, 
with a special interest in the following areas.

Diabetes-related Disorders

• Diabetes Type 1
• Diabetes Type 2
• Diabetic Gastroparesis
• Diabetes complications

Cardiovascular Outcomes

• Outcomes in obesity
• Atherosclerotic Disease
• Orthostatic Hypotension
• Hypertension
• Critical Limb Ischemia
• Dyslipidemia
• Diabetic foot ulcer
• Venous leg ulcers
• Surgical Wounds
• Ischemic Diabetic Foot ulcers
• Mild Diabetic Foot Infections

Nephrology Disorders

• Chronic Kidney Disease
• Diabetic Nephropathy

Gastrointestinal Disorders

• Gastroparesis
• Irritable Bowl Syndrome

Participant Information

Learn about clinical trials in Los Angeles and how volunteering for a study can benefit you.

Our Research Team

Our Principal Investigator and Sub-Investigators

The research team is led by our esteemed Principal Investigator, Dr. Felix Sigal . He is a dedicated clinician and thought-leader with over 20 years of clinical experience. Our team includes valued colleagues who support research efforts as Sub-Investigators.

• Dr. Parham Parto, Cardiologist 
• Dr. Ali Golshan, Vascular and Interventional Radiologist 
• Dr. Mark Barats, Nephrologist 
• Dr. Morris Silver, Gastroenterologist 
• Dr. Michael Andrew Roberts, Ophthalmologist 
• Dr. Salis Shrestha, Foot and Ankle Surgeon

Our Partners in Research

We are equipped with the experience, expertise and facility to meet the individual needs of each sponsor and research protocol.

Sponsor Testimonials

Hear from our sponsors about their experience with us.

Nikolai Sopko

Chief scientific officer & vp r&d, polarityte.

We have worked with Dr. Sigal and his team at Angel City Research in all three of our randomized controlled trials evaluating chronic wounds including our current pre-market pivotal RCT for BLA approval. They have consistently been one of our top enrolling sites and produce high quality data, which we have successfully used to open our IND and receive RMAT designation. Dr. Sigal and the Angel City Research team are professional, timely, and courteous and a pleasure to work with.

Jill Boertlein

Senior clinical trial manager, peri.

I was pleasantly surprised at the level of responsiveness and cooperation they displayed in working together to get the study up and running. Dr. Sigal’s site staff is always polite, engaging and easy to work with to reach a common goal. It’s truly a delight to work with them.

Participate in a Study

Join a study to learn more about your condition, explore new treatments, and contribute to medical advancements.

• How It Works

818-296-6983

HERE IS HOW TO GET STARTED

As a study participant, you play a valuable role in helping to get safe, effective drugs approved for public use. Because you are such an important part of our studies, we have simplified the steps for participation.

Call Toll-Free 1-818-296-6983 or Click on a Study Below

This is the first step. All volunteers will be able to review the Informed Consent form, and the program will be carefully explained by our professional medical team.

Come in for a FREE Medical Exam

After evaluating your particular medical situation, we will invite you into our clinic for a comprehensive and complimentary physical exam.

No Special Requirements

If you meet the physical guidelines of the study, you will be asked to participate. No medical insurance is needed to participate.

Receive Compensation

Participants will be assigned to different groups, where you will be carefully monitored for treatment and safety. As a volunteer, you can earn compensation for time and travel.

Thanks for the experience! I participated in a knee study. The doctor was very good and asked a lot of questions.The medicine worked for a while then stopped but then started working again. I would recommend this service.

- laray r. -, the staff was nice, kind and pleasant. the doctor was fantastic, very happy and upbeat. my knee pain was almost gone. also the money was great and came in very handy., - yousef t. -, doctor and staff are very caring and efficient. the doctor is caring and knowledgeable. the office visits were conducted in a timely manner. top notch professionalism., - patricia c. -, reserve your place now….

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• Diversity in Clinical Research
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• What Is A Clinical Trial?

California Paid Clinical Trials

Match to clinical trials, popular cities.

Kaiser Permanente houses over 6,000 physicians in southern California and it is also one of the largest research centers on the state. On its clinical trial division, Kaiser Permanente conducts clinical trials of almost every specialty funded by pharmaceutical companies, government, and foundations.

The Cedars-Sinai Medical Center located in Los Angeles is one of the largest research centers owned and operated by a private hospital in the United States. Focusing on biomedical, cancer, and heart research among other specialties, you can find almost any type of clinical trials for both health and non-healthy volunteers at the research division of Cedar-Sinai Medical Center.

There are around 100,000 clinical trials happening every year across the United States about almost every condition out there. While most clinical trials are testing drugs or medical devices there are also many behavioral and observational trials going on at any point in time. Many paid research studies are held at these California locations.

Clinical trials are incredibly important for making new medical and scientific discoveries, finding new and better methods for diagnosing medical conditions early, testing new interventions, and even developing safer and more effective surgical procedures.

In order for all these discoveries to me made available to the general population they need to go through years of rigorous testing both in healthy and non-healthy volunteers. During those years, medical professionals follow a protocol that has been previously approved by the FDA or other regulatory agency to test the effectiveness and safety of their discovery.

Other people choose to participate in a clinical trial because they feel it is a good way to contribute to the advancement of medical knowledge and that their participation can help many people in the future. The following lists of trials are broken down by condition, and to find a specific clinical trial in your area click through to clinicaltrials.gov.

Search Clinical Trials in California by Condition

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2024 Hanson-Thorell Family Research Awards Launch New Studies to Improve Alzheimer’s Disease and Sarcopenia Treatments

Home » 2024 Hanson-Thorell Family Research Awards Launch New Studies to Improve Alzheimer’s Disease and Sarcopenia Treatments

USC Leonard Davis School professors are launching studies to examine treatments and potential treatments for Alzheimer’s disease and sarcopenia.  As recipients of the 2024 Hanson-Thorell Family Research Awards, Assistant Professor Michelle Keller and Research Assistant Professor Hiroshi Kumagai each received $25,000 for one-year pilot projects aiming to improve how these two common age-related conditions might be treated and potentially lower the costs for doing so.

Keller’s study looks at new Alzheimer’s therapies and seeks to explore how doctors decide whether to prescribe them, which factors influence their decisions, and how patients from various backgrounds perceive the value and risks of these treatments.

Alzheimer’s disease is a growing health concern in the U.S., especially among older adults, with the number of affected individuals expected to nearly triple by 2050. New drugs like lecanemab offer hope by slowing disease progression, but they come with serious risks, including brain swelling and bleeding, and are very expensive. Doctors and patients must carefully weigh the benefits against these risks and costs.

“This decision-making is particularly complex for people from diverse racial and ethnic backgrounds, who may have different perspectives on the risks due to factors like health literacy, access to care, and trust in the medical system,” said Keller. “Findings from this pilot study will be used as the basis for a future proposal to the National Institutes of Health and I am so grateful to have received this award to jump-start my research in this important area.”

Keller’s goal is to understand how different health systems are using new Alzheimer’s drugs and to create better ways for doctors and patients to talk about the risks and benefits of these medications. She says the research could also hold policy implications by highlighting the challenges people face in getting treatment and how much it might cost both nationally and in individual states.

Kumagai’s proposal introduces a newly discovered mitochondrial protein protein called PUTZ, that may play a role in sarcopenia, or age-related muscle loss, a major but under-researched area in aging science. The study will also investigate whether blocking this protein could be a new way to treat the condition. Sarcopenia and related frailty lead to higher health risks and cost the U.S. healthcare system about $40 billion each year.

“This research could pave the way for new treatments that not only improve health outcomes but also reduce healthcare costs,” said Kumagai. “I am so appreciative of the Hanson-Thorell family’s generosity in allowing me to advance research in this area.”

Kumagai will also evaluate whether exercise can protect against the harmful effects of PUTZ and will test this by having young and older mice, with and without the PUTZ gene, exercise on a running wheel and then check their muscle size and strength.

“The hope is that these experiments will provide essential information that could lead to a bigger, long-term project focused on developing treatments that block PUTZ to help prevent frailty and muscle loss in aging,” said Kumagai.

The Hanson-Thorell Family Research Award recognizes the importance of innovative research and encourages young scientists to push the boundaries of their fields. The award, supported in part by Board of Councilors Chair Shari Thorell and her husband Bob, originated with funding from Shari’s father and former Board of Councilors Chairman Al Hanson.

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