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Research participants are partners in discovery at the NIH Clinical Center, the largest research hospital in America. Clinical research is medical research involving people The Clinical Center provides hope through pioneering clinical research to improve human health. We rapidly translate scientific observations and laboratory discoveries into new ways to diagnose, treat and prevent disease. More than 500,000 people from around the world have participated in clinical research since the hospital opened in 1953. We do not charge patients for participation and treatment in clinical studies at NIH. In certain emergency circumstances, you may qualify for help with travel and other expenses Read more , to see if clinical studies are for you.

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Email sent to the National Institutes of Health Clinical Center may be forwarded to appropriate NIH or outside experts for response. We do not collect your name and e-mail address for any purpose other than to respond to your query. Nevertheless, email is not necessarily secure against interception. This statement applies to NIH Clinical Center Studies website. For additional inquiries regarding studies at the National Institutes of Health, please call the Office of Patient Recruitment at 1-800-411-1222

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Discovery resource for women’s health research now available.

Partnering with the National Library of Medicine (NLM), the Office of Research on Women's Health (ORWH) launched the first phase of a novel discovery resource for women’s health research (WHR), called DiscoverWHR.

DiscoverWHR is a centralized resource for women’s health research and information from NIH that supports NIH-wide efforts to close the gaps in women’s health across the life course.

This innovative resource simplifies the finding women’s health information by patients, caregivers, medical professionals, researchers, and the public.

Users can explore the following research areas:

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Learn more about DiscoverWHR , the NIH Discovery Portal for Women’s Health Research.

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NIH launches harm reduction research network to prevent overdose fatalities

Scientists will test community-based approaches to prevent drug overdoses, curb high death rates

To address the overdose crisis in the United States, the National Institutes of Health has established a research network that will test harm reduction strategies in different community settings to inform efforts to help save lives. The harm reduction research network’s efforts build on existing harm reduction research, and represent the largest pool of funding from NIH to date to study harm reduction strategies to address overdose deaths.

More than 107,000 people in the United States died from a drug overdose in 2021, according to provisional data from the U.S. Centers for Disease Control and Prevention. These deaths are largely driven by the proliferation of cheap, potent synthetic drugs like fentanyl contaminating the drug supply, including in heroin, cocaine, methamphetamine, and counterfeit pills.

Harm reduction is an evidence-based, often life-saving approach that directly engages people who use drugs to prevent overdose, disease transmission and other harms. Researchers will test strategies to connect enrolled participants who use drugs with services and treatments and measure the effectiveness of these interventions in reducing overdose deaths and other outcomes.

“Getting people into treatment for substance use disorders is critical, but first, people need to survive to have that choice,” said National Institute on Drug Abuse (NIDA) Director Nora D. Volkow, M.D. “Harm reduction services acknowledge this reality by aiming to meet people where they are to improve health, prevent overdoses, save lives and provide treatment options to individuals. Research to better understand how different harm reduction models may work in communities across the country is therefore crucial to address the overdose crisis strategically and effectively.”

Funded by the NIH Helping to End Addiction Long-term Initiative, or NIH HEAL Initiative, through NIDA, the awards are expected to total approximately $36 million over five years, pending the availability of funds. Studies will enroll participants to investigate a range of harm reduction approaches, such as distributing naloxone, a lifesaving medication to reverse overdose, and fentanyl test strips, which people can use to determine if drugs are contaminated with fentanyl.

The research network will also examine the efficacy of moving harm reduction services and tools into communities via mobile vans, peer support specialists, internet- and smartphone-based tools and other types of outreach. By offering these services, harm reduction may be a first step interaction that also helps people access treatment for addiction and other healthcare.

Novel forms of harm reduction services may prove helpful in rural areas of the country, where people may need to travel long distances to receive care and services. According to 2020 CDC data , rural counties experienced 26.2 overdose deaths per 100,000 people, which was only slightly lower than the rates in urban counties (28.6 deaths per 100,000 people); overdose deaths involving psychostimulants were higher in rural counties than in urban counties from 2012 through 2020. Additionally, several projects will be aimed at populations disproportionally affected by the negative impacts of drug use, including Black and Latino/Latina communities, and women.

“The opioid and overdose crisis continues to evolve in dangerous and unpredictable ways, but scientific solutions that embrace innovative research and community connections offer the best hope for saving lives across America,” said NIH HEAL Initiative Director Rebecca G. Baker, Ph.D.

The new harm reduction research network will include nine research projects and one coordinating center. Grantees will investigate harm reduction strategies for their effectiveness in preventing drug overdoses and other adverse outcomes, sustainability and level of individual and community engagement. All projects will have a community advisory board and/or people with lived experience will have paid positions to support the research. Leading institutions and their projects include:

• Johns Hopkins University, Baltimore: Evaluating the impact of mobile van-delivered harm reduction services on overdoses among women in Baltimore who use drugs. Mobile vans will offer participants supplies like naloxone, fentanyl test strips and necessities such as food and clothing, brief trauma-informed counseling, and referrals to drug treatment, medical care and social services.
• New York University School of Medicine, New York City: Investigating the effects of a harm reduction intervention delivered via mobile van to Black and Latino/Latina participants who use drugs in New Haven, Connecticut, and the borough of the Bronx, New York. A community-based care coordinator will assess the unique needs of each participant (such as housing, food assistance, and mental health treatment) and then link them to appropriate services.
• Oregon Health and Science University, Portland: Evaluating two interventions – contingency management, an evidence-based behavioral intervention for the treatment of a variety of substance use disorders, and the identification of personal harm reduction goals with the support of a peer with lived experience – at community-based organizations in rural Oregon to increase the availability and effectiveness of harm reduction services for people who use methamphetamine.
• Research Triangle Institute, North Carolina: Assessing the reach, effectiveness, adoption, implementation, and maintenance of harm reduction services in San Francisco, with the goal of helping public health agencies, community-based organizations, and policy makers better understand how to tackle health-related harm among people who use drugs.
• Research Triangle Institute, North Carolina: Establishing a harm reduction research network coordination center that will provide support to the nine research studies in the harm reduction research network.
• University of Chicago: Measuring the use of harm reduction services and investigating how to successfully implement remote harm reduction strategies in rural Illinois communities. For instance, examining “secondary distribution” approaches, in which people who obtain harm reduction supplies (e.g., naloxone or fentanyl test strips) from harm reduction service providers share them with other people who use drugs who are currently without access to these providers.
• University of Nevada-Reno: Testing ways to identify and support “overdose responders” (people who use drugs who respond to overdoses in their peers), to better understand barriers to naloxone use and increase long-term use of naloxone among people who use drugs.
• University of Pittsburgh: Developing and testing an intervention aimed at changing behaviors and reducing risks among Black people who use drugs who visit the emergency department in Pittsburgh. The intervention, which will be delivered to participants by peers with lived experience of drug use, bundles evidence-based harm reduction strategies including take home naloxone and fentanyl test strips.
• University of Wisconsin-Madison: Developing and testing an intervention consisting of up to four internet- and smartphone-based tools designed to improve access to harm reduction services for hardly reached people, enrolling participants in both urban and rural regions of Wisconsin.
• Weill Medical College of Cornell University, New York City: Determining where and how to best provide mail-delivered harm reduction supplies by investigating the barriers to mail-delivery of harm reduction supplies, predictors of use and long-term engagement with mail-delivered harm reduction services and preferences of study participants who use them.

NIH is not providing funds for the purchase of pipes, syringes or needles.

The new harm reduction research network joins other ongoing harm reduction research funded by NIDA and the NIH HEAL Initiative, which address drug overdoses, drug use, transmission of HIV and hepatitis C, and intersectional stigma. NIDA and the NIH HEAL Initiative also fund substantial research on drug use and addiction prevention, diagnosis, treatment, and recovery support .

For more information on substance and mental health treatment programs in your area, call the free and confidential National Helpline 1-800-662-HELP (4357) or visit www.FindTreatment.gov .

Helping to End Addiction Long-term and NIH HEAL Initiative are registered service marks of the U.S. Department of Health and Human Services.

About substance use disorders: Substance use disorders are chronic, treatable conditions from which people can recover. In 2020, over 40 million people in the United States had at least one substance use disorder. Substance use disorders are defined in part by continued use of substances despite negative consequences. They are also relapsing conditions, in which periods of abstinence (not using substances) can be followed by a return to use. Stigma can make individuals with substance use disorders less likely to seek treatment. Using preferred language can help accurately report on substance use and addiction. View NIDA’s online guide .

About the National Institute on Drug Abuse (NIDA): NIDA is a component of the National Institutes of Health, U.S. Department of Health and Human Services. NIDA supports most of the world’s research on the health aspects of drug use and addiction. The Institute carries out a large variety of programs to inform policy, improve practice, and advance addiction science. For more information about NIDA and its programs, visit www.nida.nih.gov.

About the NIH HEAL Initiative: The Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, is an aggressive, trans-NIH effort to speed scientific solutions to stem the national opioid public health crisis. Launched in April 2018, the initiative is focused on improving prevention and treatment strategies for opioid misuse and addiction, and enhancing pain management. For more information, visit: https://heal.nih.gov .

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov .

NIH…Turning Discovery Into Health®

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NIEHS will conduct high-quality, innovative environmental health sciences research. Research on the effects of the environment on biological systems and processes is central to the NIEHS mission to understand how the environment affects human health. State-of-the-art biomedical tools help produce new understanding of the effects of specific exposures up to and including the full “exposome,” which represents the compilation of exposures over the lifespan. The exposome will help to establish the knowledge base of environmental effects on biology and health from the subcellular level to the whole individual. NIEHS’ Research Areas of Emphasis include group and population studies in environmental epidemiology, as well as clinical studies aimed at understanding risk and beneficial factors for a wide variety of environmentally mediated diseases and conditions. Efforts are focused on understanding effects on processes and mechanisms across the lifespan, in different individuals and in different sexes, including collaboration on activities with the NIH Office of Research on Women’s Health. NIEHS will maintain a focus on mechanisms during windows of susceptibility through multiple developmental stages. Another priority is to continue to move toward a deeper understanding of individual variability in response to the environment that arise from multiple factors (genetic, epigenetic, underlying health status, among others). NIEHS will continue to develop, validate, and support new tools and methods necessary for advancing the research described in this plan.

NIEHS research will continue to focus on environmental exposures of special interest and concern for public health, ranging from widespread chemical exposures; nonchemical stressors including social determinants of health; and exposures related to climate change and human activities that impact the environment. Additionally, there will be a focus on better understanding how specific environmental factors can positively impact human health and contribute to the influences that shape human health. The Research Areas of Emphasis represent research approaches that are used to understand the effects of these and other exposures on health. As new data and research bring to light emerging environmental exposures, NIEHS will consider this new information and its readiness to be addressed through NIEHS-supported research.

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Area 2: Precision Environmental Health

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Area 3: Mechanistic Biology and Toxicology

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Area 4: Data Science and Computational Biology

Data science and computational biology are increasingly foundational to conducting environmental health and biomedical research for the purpose of enhancing clinical care and public health outcomes.

Area 5: Environmental Health Disparities, Environmental Justice, and Health Equity

Understanding the underlying causes of environmental health disparities and reducing the environmental impacts on the health of the communities who are most affected is fundamental to NIEHS’ goal of enhancing environmental justice and health equity for all people.

Area 6: Climate Change Impacts on Human Health

As the reality of a changing climate unfolds across the globe in record-breaking heat, extreme storms and wildfires, droughts, floods, and the spread of vector-borne diseases, the need to understand the effects of these changes on human health is increasingly urgent.

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Definition of human subjects research.

• Obtains information or biospecimens through intervention or interaction with the individual, and uses, studies, or analyzes the information or biospecimens; or
• Obtains, uses, studies, analyzes, or generates identifiable private information or identifiable biospecimens."

Are you planning on conducting human subjects research? Learn more about research that meets the definition human subjects research, Federal regulation requirements, and whether your project may be considered exempt. Also, learn about NIH specific considerations and become more familiar with NIH policies, and other regulations as it relates to human subjects research protections.

Decision Tool: Am I Doing Human Subjects Research?

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Human Subjects Research Infographic

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Exempt Human Subjects Research Infographic

This resource is a guide to simplify the understanding of the exemptions from the federal regulations for the protection of human subjects research. It summarizes Exemptions 1, 2, 3, 4, 5, 6, 7 and 8, providing basic definitions, examples of studies that meet and do not meet the criteria of the exemption, and aspects one must consider when engaged in exempt or non-exempt human subjects research.

Research Involving Private Information or Biospecimens Flowchart

Studies involving the use of human specimens or data may or may not be considered to be research involving human subjects, depending on the details of the materials to be used. Use this flowchart to help determine if studies involving private information or biospecimens may meet the definition of human subjects research.

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Learn about research activities which may qualify for a public health surveillance exclusion. Find useful information, key resources, and instructions for NIH applicants and offerors.

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NIMHD Press Release

Announcement.

March 31, 2021

The Science of Health Disparities Research integrates various research disciplines into one comprehensive, first-of-its-kind volume.

The National Institutes of Health (NIH) today charted a path for NIH to advance the science of minority health and health disparities for the next five years and beyond, with the release of the NIH-Wide Minority Health and Health Disparities Strategic Plan, 2021-2025: Taking the Next Steps .

The plan’s goals for advancing minority health and health disparities research and promoting health equity are in three categories:

• Scientific Research , such as advancing the understanding of the root causes of health disparities
• Research-Sustaining Activities , such as strengthening the national research capacity to address minority health and health disparities, especially in minority-serving institutions
• Outreach, Collaboration, and Dissemination , such as cultivating and expanding the community of researchers and advocates in the area of minority health and health disparities

Development of the strategic plan was led by the National Institute on Minority Health and Health Disparities (NIMHD), in collaboration with all NIH Institutes, Offices, and Centers. To ensure that stakeholders at multiple levels were involved in this strategic planning process, NIMHD gathered input from experts within and outside of NIH.

“By gaining a better understanding of the different pathways of health disparities and the contributors to certain outcomes in populations with health disparities, we will be able to improve health for all and promote health equity,” said NIMHD Director Eliseo J. Pérez-Stable, M.D. “This strategic plan shows the path. We are proud of this plan and look forward to implementing it along with the rest of NIH.”

The strategic plan’s evolution started more than eight years ago, with town hall meetings to collect data on critical research areas in minority health and health disparities. With input from NIH Institutes, Offices, and Centers, NIMHD led an analysis of NIH’s portfolio of minority health and health disparities research, including a search for gaps in the science and structures that support research aligned with their mission. Development continued with a science visioning process, then listening sessions , both virtual and in person, to collect community-level input from across the country.

NIH has an ongoing role to play in reducing health disparities and improving minority health across all diseases and conditions. NIH’s 27 Institutes and Centers contribute to science and support training, workforce development, capacity building, and other activities that advance the field. This strategic plan demonstrates the commitment of all of NIH to improving minority health and reducing health disparities.

Over the next five years, NIH will evaluate the agency’s progress in meeting the strategic plan’s objectives. Access The NIH-Wide Minority Health and Health Disparities Strategic Plan, 2021-2025: Taking the Next Steps online.

About the National Institute on Minority Health and Health Disparities (NIMHD): NIMHD leads scientific research to improve minority health and reduce health disparities by conducting and supporting research; planning, reviewing, coordinating, and evaluating all minority health and health disparities research at NIH; promoting and supporting the training of a diverse research workforce; translating and disseminating research information; and fostering collaborations and partnerships. For more information about NIMHD, visit www.nimhd.nih.gov .

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov .

Page updated July 13, 2021

Sheleka Turnbull

NIMHD Fact Sheet

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[N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia]

Affiliation.

• 1 N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia, [email protected].
• PMID: 34190468
• DOI: 10.32687/0869-866X-2021-29-3-415-420

The medication support of population is an integral part of health care system reflecting the state of social and economic sectors in conditions of national pharmaceutical market development that as opposed to markets of other goods has such specific characteristics as wide scale, large selection of assortment, science linkage, durational cycle of medication development. Lately, intensive work was implemented improving national medication supply system. The normative base passed through significant changes. The percentage of costs of medication support in total costs of health care increased. The preparation of pilot project concerning system of reimbursement of appropriated medications proceeds. However, despite all these actions, availability of medications does not improve. The components of medicinal availability can be structured as physical, spatial temporal, assortmental and infrastructural ones. The article presents overall analysis of most acute challenges in the area of medication supply. The proposals were formulated concerning development of system of medication support of population.

Keywords: accessibility; assortment availability; funding; pharmaceutical market; provision of medication.

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