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Theses and Dissertations--Pharmacy

Theses/dissertations from 2024 2024.

Investigating a New Drug Target in Alzheimer’s Disease: NOX2 , Tiffany Adams

Design of Kappa Opioid Receptor Agonists for Potential Treatment of Multiple Sclerosis , Lindsay Kornberger

Sensitizing KEAP1 loss non-small cell lung cancer to artesunate anti-cancer activity , Keng Hee Peh

INHIBITING PI3K/AKT TO ENHANCE BRAIN UPTAKE OF ANTICANCER AGENTS IN GLIOBLASTOMA , Louis Rodgers

NEUROIMMUNE RESPONSE AND NEURODEGENERATION IN ADOLESCENT RATS FOLLOWING BINGE ALCOHOL EXPOSURE , Catherine Van Doorn

Theses/Dissertations from 2023 2023

Self-Assembled Ternary Polypeptide Nanoparticles With Improved Biostability For Drug Delivery In Cancer Therapy , Preye Mike Agbana

Investigation of Folate-Poly(Glutamic Acid)/Polyethylenimine/DNA Complexes for in vitro Gene Delivery , Caleb Akers

POPULATION-BASED EVALUATION OF TREATMENT PATTERNS, DRUG-DRUG INTERACTIONS, AND CARDIOVASCULAR RISK IN PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER , Yue Cheng

An Epidemiological and Pharmacokinetic-pharmacodynamic Investigation into the Impact of Carbapenem-resistant Enterobacterales , Justin Clark

STRIVING FOR APPROPRIATE ANTIBIOTIC USE: A BIOMARKER INITIATIVE, AND OUTCOMES ASSOCIATED WITH AZITHROMYCIN EXPOSURE , Amanda Gusovsky

New Tools for Biocatalysis: Studies on the Carminomycin 4-O-Methyltransferase DnrK , Elnaz Jalali

Optimization of Orally Bioavailable Inhibitors of Defective in Cullin Neddylation 1 (DCN-1) , Leah Kovalic

Genetic and Pharmacogenetics Associations of Cancer Disparities in Appalachia , Nan Lin

Design and Synthesis of Small Molecular Inhibitors of DCN1-UBE2M Interaction , Tucker J. Moseley

Effectiveness of a long-acting cocaine hydrolase in metabolizing cocaine and its physiologically active metabolites , Linyue Shang

Anti-Inflammatory and Analgesic Effects of Highly Selective Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors , Madeline Stewart

INVESTIGATING THE USE OF mPGES-1 INHIBITORS FOR THE TREATMENT OF ABDOMINAL AORTIC ANEURYSMS , Lauren M. Weaver

DEVELOPING A BIOCATALYTIC TOOLBOX TO AID IN UNDERSTANDING NUCLEOSIDE ANTIBIOTICS , Jasmine Brianna Woods

BIOINFORMATIC ANALYSIS OF PROTEOMIC AND GENOMIC DATA FROM NSCLC TUMORS ON PROGNOSTIC AND PREDICTIVE FACTORS OF IMMUNOTHERAPY TREATMENT , Mark Wuenschel

Theses/Dissertations from 2022 2022

Response of Dopaminergic System to Cocaine Exposure, Recovery after Cocaine Abstinence, and Impact of a Long-acting Cocaine Hydrolase , Jing Deng

ANALYSIS OF POTENTIAL FACILITATORS TO USE OF HIV PRE-EXPOSURE PROPHYLAXIS (PrEP) IN A YOUNG TRANSGENDER POPULATION , Noah Dixon

Studies Toward the Development of an Improved Countermeasure for Synthetic Opioid Overdose , Sidnee L. Hedrick

Development of zafirlukast derivatives active against Porphyromonas gingivalis , Kaitlind C. Howard

Investigating the Physical Stability of Amorphous Pharmaceutical Formulations , Travis W. Jarrells

THE RELATIVE CONTRIBUTION OF LIVER AND INTESTINE IN REVERSE CHOLESTEROL TRANSPORT , Rupinder Kaur

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Home > Pharmacy > PHP > PHP_ETD

Pharmacy Practice and Clinical Research Department Theses and Dissertations

Theses/dissertations from 2024 2024.

A C-MET RECEPTOR TARGETING NANOPARTICLE PLATFORM FOR COMBINATION THERAPY AGAINST HEPATOCELLULAR CARCINOMA , Subarna Das

CHEMICAL INVESTIGATION OF MEMBRANE VESICLES ISOLATED FROM PSEUDOALTEROMONAS RUBRA , Margaret Hill

MECHANISTIC APPROACH TO UNDERSTANDING ADVERSE LIVER OUTCOMES RELATED TO PFAS EXPOSURE IN NEONATAL AND ADULT MICE , Emily Kaye

DEVELOPING EFFECTIVE PHYSICAL AND CHEMICAL ADJUVANTS FOR INFLUENZA AND TUMOR VACCINES , Yibo Li

MECHANISTIC AND TOXICOKINETIC ANALYSIS OF PERFLUOROALKYL SUBSTANCES: PROTEOMICS APPROACH AND THE ROLE OF FATTY ACID BINDING (FABP) , Seyed Mohamad Sadegh Modaresi

DNA DAMAGE, MODIFICATION AND REPAIR , Xianhao Zhou

Theses/Dissertations from 2023 2023

UNDERLYING MECHANISMS OF UBIQUITIN SPECIFIC PEPTIDASE 2 ISOFORMS REGULATION IN HEPATOCELLULAR CARCINOMA BY THE FARNESOID X RECEPTOR SIGNALING PATHWAY , Winifer M. Ali

13C LABELING FOR CHO CELL METABOLISM TRACING AND MS BASED ANALYSIS FOR ADVANCED UPSTREAM CULTURE MONITORING TO SUPPORT CQA UNDERSTANDING , Xin Bush

A STUDY OF THE STRUCTURE-ACTIVITY RELATIONSHIPS OF CARCINOGENIC PROTEIN- AND DNA-BINDING CHEMICALS , Alicia M. Crisalli

MECHANISMS OF PPAR-ALPHA TARGETED THERAPY IN CHOLESTASIS: TRANSLATIONAL STUDIES , Gina Gallucci

ENHANCING THE EFFICACY OF INHALABLE NANOPARTICLE FORMULATIONS USING BIOMIMETIC LUNG SURFACTANT , Andrea Jennifer Gonsalves

OPIOIDS AND OPIOID USE DISORDER TREATMENT IN PREGNANCY: SPONTANEOUS ABORTION AND CHILDHOOD NEURODEVELOPMENTAL DISORDERS , Mennatullah Hasan

CHOOSING WISELY IN PROPHYLACTIC NEUROKININ-1 RECEPTOR ANTAGONIST USE AMONG WOMEN WITH BREAST CANCER: A RETROSPECTIVE COHORT STUDY , Shweta Kamat

REAL-WORLD MEDICATION MANAGEMENT OF INDIVIDUALS WITH SICKLE CELL DISEASE , Abiodun John Ologunowa

EVALUATION OF THE TOXICOKINETIC MECHANISMS OF PERFLUOROALKYL SUBSTANCES: ACCUMULATION, DISTRIBUTION, AND ELIMINATION , Sangwoo Ryu

CHILDREN’S OUTCOMES AND MATERNAL OPIOID EXPOSURES DURING PREGNANCY , Shuang Wang

DEVELOPMENT OF LOCALIZED DRUG DELIVERY STRATEGIES FOR THE TREATMENT OF CANCERS AND INFECTIOUS DISEASES , Weizhou Yue

Theses/Dissertations from 2022 2022

TREPROSTINIL, A PROSTACYCLIN ANALOG, PROTECTS KIDNEY FROM RENAL ISCHEMIA-REPERFUSION INJURY: PRECLINICAL STUDIES IN A RAT MODEL OF ACUTE KIDNEY INJURY , Meiwen Ding

THE MECHANISTIC AND ETIOLOGICAL LINK BETWEEN BILE ACID DYSREGULATION AND PRETERM BIRTH , Syed Fayaz Ul Haq Hashmi

TREPROSTINIL IMPROVES HEPATIC CYTOCHROME P450 METABOLISM DURING RENAL ISCHEMIA REPERFUSION INJURY , Daniel Kelly

PREDICTORS OF EPI PROCOLON UTILIZATION , Eric Lamy

AN EVALUATION OF THE EFFECTIVENESS AND SAFETY OF DIRECT ORAL ANTICOAGULANTS VERSUS WARFARIN IN CHRONIC LIVER DISEASE, AND AFTER ANTICOAGULANT-RELATED MAJOR BLEEDING , Oluwadolapo D. Lawal

CHEMICAL BIOLOGY OF DNA ADDUCT REPAIR, BYPASS AND MUTAGENESIS , Rui Qi

CHEMICAL INVESTIGATION OF METABOLITES PRODUCED BY MARINE PSEUDOALTEROMONAS SPP. , Margaret Rosario

A PROTEOMIC APPROACH TO UNDERSTANDING REGULATORY PATHWAYS IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) , Teresa Sierra

IMPACTS OF HYPERTENSION AND THROMBOSIS IN A RAT MODEL OF CEREBRAL AMYLOID ANGIOPATHY (rTg-DI) , Aleksandra Stanisavljevic

PHYTOCHEMICAL ANALYSIS AND BIOLOGICAL EVALUATION OF MAPLE (Acer saccharum) SAP WATER , Kara Torrey

TRANSLATION AND VALIDATION OF MYELOID DERIVED SUPPRESSOR CELL PROTEOMIC TARGETS IN LIVER AND LUNG TUMORS , Justin Trickett

A MULTI-YEAR INVESTIGATION OF THE SPECIALIZED METABOLITE COMPOSITION OF TRICHODESMIUM SPP. , Christopher William Via

Theses/Dissertations from 2021 2021

PHARMACIST-ADMINISTERED PEDIATRIC INFLUENZA VACCINATION IN THE UNITED STATES , Dana M. Gates

DUAL-DRUG NANOPARTICLE FORMULATION FOR INHALED DELIVERY IN IDIOPATHIC PULMONARY FIBROSIS TREATMENT , Moez Ghumman

INVESTIGATING TOLFENAMIC ACID AND ITS ANALOGS AS POTENTIAL ALZHEIMER’S DISEASE THERAPEUTICS , Jaunetta Hill

HEPATOPROTECTIVE EFFECTS OF TREPROSTINIL DURING RENAL ISCHEMIA-REPERFUSION INJURY , Joyce Hou

EVALUATING NATURAL PRODUCT LIBRARIES WITH EMPHASIS ON IN VITRO PERMEABILITY WORKFLOWS , Riley D. Kirk

ANTI-INFLAMMATORY EFFECTS OF POLYPHENOL-ENRICHED EXTRACTS , Chang Liu

REAL-WORLD UTILIZATION AND EXPENDITURE OF TOP-DOWN AND STEP-UP THERAPY IN INFLAMMATORY BOWEL DISEASE , Kanya K. Shah

EVALUATION OF MEDICATIONS FOR OPIOID USE DISORDER ON OVERDOSE AND HEALTHCARE UTILIZATION IN THE US , Tianyu Sun

SELF-ADJUVANTED VIRUS-LIKE PARTICLE FOR SAFE AND HIGHLY IMMUNOGENIC VACCINATION , Yiwen Zhao

Theses/Dissertations from 2020 2020

PERFLUOROOCTANESULFONIC ACID (PFOS) AS A POTENTIAL RISK FACTOR FOR LATE-ONSET ALZHEIMER’S DISEASE , Veronia Basaly

THE COMPARATIVE EFFECTIVENESS, SAFETY, AND COST OF ORAL P2Y12 ANTIPLATELET AGENTS FOLLOWING ACUTE CORONARY SYNDROMES , Nicholas Belviso

PRESCRIPTION CONTROLLED SUBSTANCE UTILIZATION: EVALUATING BENZODIAZEPINE DOSE INTENSITY, DEVELOPMENT AND APPLICATION OF A MEASUREMENT FRAMEWORK, AND USE OF TRAMADOL AMONG PATIENTS WITH HIGHER RISK , Eric P. Borrelli

CHEMICAL INVESTIGATION OF BACTERIAL INTERACTIONS INVOLVING PATHOGENS , Hilary Joan Grant Ranson

EVALUATION OF KEY PERFLUOROALKYL SUBSTANCES TO INDUCE LIVER STEATOSIS IN MOUSE AND HUMAN MODELS , Emily Sara Marques

CHEMICAL INVESTIGATIONS OF PECTIC OLIGOSACCHARIDES FROM VACCINIUM MACROCARPON , Zhiyuan Peng

DRUG-INDUCED LIVER INJURY: A PREDICTIVE MODEL, MITOCHONDRIAL TOXICITY MECHANISMS RISK, AND ANTIPSYCHOTIC MEDICATIONS RISK IN A REAL-WORLD SETTING , Payal Rana

EVALUATION OF THE RELATIONSHIP BETWEEN CENTRALITY AND INDIVIDUAL-LEVEL CHARACTERISTICS AMONG PWID , Benjamin Skov

Theses/Dissertations from 2019 2019

COMPARATIVE EFFECTS OF TOLFENAMIC ACID AND DONEPEZIL ON BEHAVIOR AND TAU PATHOLOGY BIOMARKER LEVELS , Abdullah G. Alharbi

POLYPHARMACY IN CANCER PATIENTS: HEALTH-RELATED QUALITY OF LIFE, EXPENDITURES, AND ADVERSE EVENTS , Zachary R. Babcock

USE OF HYPHENATED MASS SPECTROMETRY TO UNCOVER TRUE NAFLD EFFECT ON HUMAN DRUG DISPOSITION PROTEINS , Benjamin Joseph Barlock

DNA damage, repair and mutational spectrum , Ke Bian

ANTI-INFLAMMATORY EFFECTS OF POLYPHENOL-ENRICHED EXTRACTS AND THEIR GUT MICROBIAL METABOLITES , Nicholas A. DaSilva

BUDGET IMPACT ANALYSIS OF NOVEL ABUSE DETERRENT OPIOID FORMULATIONS IN A POPULATION OF CHRONIC OPIOID USE , Andrew Descoteaux

DEVELOPMENT OF PEDIATRIC ANTI-HIV FORMULATIONS WITH IMPROVED DISSOLUTION CHARACTERISTICS , Ryan Ivone

LASER-ASSISTED TRANSDERMAL DRUG DELIVERY AND VACCINATION , Prateek Kakar

SHORT-TERM COST-EFFECTIVENESS OF SECOND-GENERATION LONG-ACTING INJECTABLE ANTIPSYCHOTICS AS COMPARED WITH ORAL ANTIPSYCHOTICS IN PREVENTING REHOSPITALIZATION OR TREATMENT SWITCH IN PATIENTS WITH SCHIZOPHRENIA , Tyler Mantaian

AN ‘OMICS APPROACH TO DIET & STRUCTURE IMPACT ON PERFLUOROALKYL SUBSTANCE INDUCED LIVER DISEASE , Marisa Pfohl

AN OMICS BASED APPROACH FOR THE IDENTIFICATION OF BIOMARKERS IN NON-ALCOHOLIC FATTY LIVER DISEASE USING IN VITRO MODELS OF HEPATIC STEATOSIS , Anitha Saravanakumar

OVERCOMING CONTEMPORARY OBSTACLES IN DRUG DELIVERY VIA ACETALATED DEXTRAN PARTICLE FORMULATIONS , Nishan K. Shah

CHEMICAL SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF METHYLATION AND GLYCATION DNA ADDUCTS , Qi Tang

Theses/Dissertations from 2018 2018

EXPRESSION AND ACTIVITY OF CYP2C8 AND 2C9 IN DIABETES MELLITUS AND NONALCOHOLIC FATTY LIVER DISEASE , Ghadah Alghaith

Economic Burden and Mortality Associated With Prescription Opioid Use , Hilary A. Aroke

MECHANISMS OF INDIVIDUAL VARIATION IN GLUCURONIDATION, SULFONATION, AND AMIDATION: BISPHENOL A AND BILE ACIDS , Adam Michael Auclair

Phytochemical Investigation of a Native North American Species, “ Acer saccarinum ” and an Endemic Saudi Arabian Species, “ Euphorbia saudiarabica ” , Abdullatif Bin Muhsinah

In Vitro Drug Metabolism and Population Pharmacokinetics as Tools for Elucidating Pharmacokinetic Variability , Enoch Cobbina

An Evaluation of Atypical Antipsychotic Use, Costs and Effectiveness in the Pediatric Population , Kellye A. Donovan

THE BIOLOGICAL FUNCTION OF HUMAN EPIDIDYMIS PROTEIN 4 IN EPITHELIAL OVARIAN CANCER , Nicole Elizabeth James

EFFECT OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) ON HEPATIC DRUG METABOLISM ENZYMES IN HUMAN , Rohitash Jamwal

REGULATION OF UBIQUITIN SPECIFIC PEPTIDASE 2 EXPRESSION BY FARNESOID X RECEPTOR IN HEPATOCELLULAR CARCINOMA , Christina Nadolny

Predictors of Concomitant Use of Prescription Opiods and Benzodiazepines in Rhode Island , Emily Patry

EFFECT OF ETHANOL ON GASTROINTESTINAL TIGHT JUNCTIONS AND P-GLYCOPROTEIN EXPRESSION AND FUNCTIONALITY , Armin Sadighi

Facilitated Excretion of Gold Nanoparticles by Copper Sulfide Nanoparticles Through the ATP7B Transporter , Xiaodong Wang

Theses/Dissertations from 2017 2017

Biotransformation and Pharmacokinetic Evaluation of PF-5190457, A Novel Drug Candidate for Alcoholism , Sravani Adusumalli

The Physiological Glucagon Receptor in Rat Heart , Kevin Agostinucci

Concomitant Use of Central Nervous System Stimulants and Depressants Prescribed in Rhode Island , Aram Babcock

Health Outcomes Research of Novel Disease Modifying Medications in Alzheimer’s Disease and Cost Burden of Early Onset Dementia , Rami Beiram

Conformational Insights Into Aminobiphenyl-Modified DNA: Implications for Mutation and Repair , Ang Cai

Using Natural Products to Treat Resistant and Persistent Bacterial Infections , Robert W. Deering

Predictors of Infection in Rheumatoid Arthritis Patients Using Anti-Tumor Necrosis Factor Agents , Tasia Liu

Circadian Rhythm: A Functional Connection Between SHP and DEC1 Transcription Factor , Marek Matczynski Marczak

Novel Pharmacological Action of Clozapine at D2 Dopamine Receptors , Joseph Michael Schrader

CES Involved Inhibition and Regulation , Yuanjun Shen

Novel Methods for Delivering and Promoting the Endosomal Escape of Nucleic Acid Based Drugs: Chiral Polyamines and Hydrophobic Nanoparticle-Containing Liposomes , Ruchi Verma

Flavin-Containing Monooxygenase-3 and 5: Tissue Distribution, Age-Related Expression and Regulation by Endoplasmic Reticulum Stress , Zhen Xu

Cardiovascular Adverse Events in Patients Receiveing QT Interval Prolonging Medications , Yizhou Ye

Theses/Dissertations from 2016 2016

Effect of Disease State on Human Carboxylesterase 1 Expression and Activity , Abdullah Aljutayli

Healthcare Costs and Impact of Medication Adherence on Outcomes in Patients on Novel Anticoagulant Therapy , Chinmay Deshpande

A Study of the Increased Risk of Bleeding Events in Patients with Blood Clotting Disorders, Associated with Antidepressant Medication Use , Adam Ehrenborg

Retrospective Cohort Study of Tobacco Dependence Treatment Patterns in a US Commercially Insured Population , Elizabeth Anne MacLean

Factors Associated With Sustained Release Psychostimulant Prescriptions for Pediatric ADHD , Robert McConeghy

Isolation, Synthesis, and Metabolism of Polyphenols: Stilbenoids, Gallotannins and Ellagitannins , Daniel B. Niesen

Antimicrobial Resistance Patterns and Protective Effects of Statins in Bacteremic Patients , Ajinkya Pawar

Investigations on Biologically Active Carbohydrates from Natural Sources , Jiadong Sun

Measuring Adherence with Antidepressant Medication: Comparison of HEDIS and PDC Methodologies , Carmen Monica Telinoiu

Cadmium Contributes to Breast Cancer Development by Influencing Cell Adhesion Network , Zhengxi Wei

Bile Acids and Premature Labor in Intrahepatic Cholestasis of Pregnancy , Sangmin You

Theses/Dissertations from 2015 2015

A Cross-Sectional Analysis of Bronchodilator Prescribing in COPD and Cardiovascular Comorbidity , Damilola Tejumola Adesanoye

NRF as an Oxidative Stress and Nutrient Responsive Transcription Factor in Calorie Restriction , Laura Armstrong

Synthesis of 2-Amino-α-Carboline and Analogues Relevant for Structural Investigations of the Corresponding DNA Adducts , Matthew S. Blake

Tolfenamic Acid: A Potential Modifier of Tau Protein in Alzheimer's Disease , Joanna K. Chang

CHEMICAL INVESTIGATION OF CANDIDATE PROBIOTICS IN AQUACULTURE AND FORMULATION OF A PROBIOTIC AGENT FOR OYSTER LARVICULURE , Christine Anh Dao

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Home > Dissertations and Theses > Pharmaceutical Sciences (PhD) Dissertations

Pharmaceutical Sciences (PhD) Dissertations

Below is a selection of dissertations from the Doctor of Philosophy in Pharmaceutical Sciences program in the School of Pharmacy.

Dissertations from 2024 2024

Perceptions of Metabolic Syndrome Management Utilization in relation with Patient Characteristics and Health-related Quality of Life , Olajide Adekunle

Mechanistic Study of Antimicrobial Cyclic Peptide [R4W4] Antibacterial Effectiveness against Methicillin-resistant Staphylococcus aureus (MRSA) , Ajayi Akinwale

Identifying The Roles of miR-17 in Ciliogenesis and Cell Cycle , Ashwaq Alanazi

Artificial Intelligence Applications for Optimizing Population and Clinical Drug Decision-Making Processes , Khulud Bukhari

Approvals, Utilization, and Cost of Biologics for the Treatment of Rheumatoid Arthritis , Roya Hosseini

Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System , Jonathan Moreno

Dissertations from 2023 2023

The Structural Characterization and Bioactivity Assessment of Nonspecific Lipid Transfer Protein 1 (nsLTP1) from Caraway (Carum Carvi) Seeds , Taibah Aldakhil

Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes , Nedaa Alomari

Authorizations, Prices, and Labeling Differences of Therapeutic Biologics Marketed in the United States and Saudi Arabia , Turki Altowairgi

The Role of Cytochrome P450 2E1 in Hepatic Ischemia Reperfusion Injury and Reactive Oxygen Species Formation , Nouf Alwadei

PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis , Sandy ElSayed

An Economic and Regulatory Analysis of Gene Therapy Products Authorized by the US Food and Drug Administration and the European Medicines Agency , Buthainah Ghanem

An Analysis of Trends of Generic Drugs and Biologic Prices in the U.S. , Mohammed Jamjoom

Genetic Mutations of K Ca 2.3 and K Ca 3.1 Channels Affect Ca2+ Sensitivity , Razan Orfali

Pharmacological and Pharmacokinetic Studies of a K Ca 2.2 Positive Allosteric Modulator , Mohammad Asikur Rahman

Application of Informatics Tools to Facilitate the Practice of Precision Medicine with Genomic Testing and Clinical Data , Michael Sayer

Characterization of Ocular Surface Pathology and Tear Film Dysfunction Due to Type 1 and Type 2 Diabetes Mellitus , Judy Weng

Dissertations from 2022 2022

The Use of Spectral Imaging to Reveal Inorganics and Organics Identity in The Biological Samples , Qamar Alshammari

Cytotoxic Activity of Non-Specific Lipid Transfer Protein (nsLTP1) and Proteomic Evaluation of Heparin-Binding Proteins from Ajwain (Trachyspermum ammi) Seeds , Saud Alshammari

Orphan Drugs: Designations, Approvals, and Prices in the US , Hana Althobaiti

Heart in Polycystic Kidney Disease is Characterized by Cardiac Dysfunction and Structural Deformation , Farideh Amirrad

Identifying a Glucocorticoid-activated GPCR that Rapidly and Non-Genomically Increases cAMP Levels in Mammalian Cells , Francisco Nunez

An Exploration of Ambulatory Visits and Medications Prescribed for Patients Diagnosed with Lupus Erythematosus in the United States , Salena Marie Preciado

Synthesis, Characterization, and Evaluation of Amphiphilic Cell-Penetrating Peptides as siRNA Delivery Tools for Cancer Therapy , Muhammad Imran Sajid

Targeting Neuronal Nitric Oxide Synthase (nNOS) for Melanoma Treatment , Shirley Tong

Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan and Arginine as Anticancer Agents and Drug Delivery System , Khalid Zoghebi

Dissertations from 2021 2021

KSHV Susceptibility and Transmission Within Tonsillar Specimens , Farizeh Aalam

Structural Characterization and in vitro Antiproliferative Activity of Non-Specific Lipid Transfer Protein 1 (nsLTP1) from Fennel ( Foeniculum vulgare ) Seeds , Mekdes Megeressa

Viral Factors Influencing Early Infection Events During Ex-Vivo KSHV Infection , Ramina Nabiee

Design and Sythesis of Conjugages of Amphiphilic Cell-Penetrating Peptides Containing Anticancer Drug and Ligand for Extra Cellular Matrix Biomarker to Provide Efficient Tumor-Targeting , Shang Eun Park

Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets , Marwa Qadri

Development of Novel Peptide-Doxorubicin Conjugates for Targeting Triple-Negative Breast Cancer , Azam Saghaeidehkordi

Pathogenesis of Dry Eye in Graft Versus Host Disease (GVHD): Role of Ocular Mucins and Conjunctival Fibrosis , Kiumars Shamloo

Design, Synthesis, and Evaluation of a Novel Cytotoxic Peptide-Doxorubicin Conjugate Targeting Triple-Negative Breast Cancer , Elmira Ziaei

Dissertations from 2020 2020

Cluster Determinant 44 (CD44) Receptor and Gout: Mechanistic Role in Pathogenesis and Therapeutic Targets , Emira Bousoik

The Roles of Primary Cilia in Cardiovascular Diseases and Cancer , Maha Jamal

Dissertations from 2019 2019

Amphiphilic Cell-Penetrating Hybrid Cyclic-Linear Peptides as a Drug Delivery System , Saghar Mozaffari

Sensory Primary Cilium is a Distinct Signaling Compartment , Rinzhin Tshering Sherpa

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PhD Theses in Clinical Pharmacy

M. Günther. Symptom burden in cancer patients: Evaluation of medication risks and development of disease-specific PRO instruments , 2023.

E. Schmulenson. Pharmacometric Modeling of Fluoropyrimidines , 2023.

A.-K. Barnert. Erweiterter Medikationsplan für Patienten mit oraler Tumortherapie , 2022.

S. Möltgen. Identification of Intracellular Protein Binding Partners of Cisplatin and Their Role in Acquired and Intrinsic Resistance, 2021.

C. Vučur. Multiprofessionelles Medikationsmanagement für ambulante Patienten mit intravenös applizierter Tumortherapie, 2020.

I. Ortland. Evaluating onco-geriatric scores and medication risks to improve cancer care for older patients, 2020.

J.-F. Schlender. Development and Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Population Model for Elderly Individuals, 2019.

K. Bitter. Geriatrische Medikationsanalyse für Pflegeheimbewohner durch öffentliche Apotheken , 2018.

A. Fritsch. Pharmacometric approaches for linking pharmacokinetic and pharmacodynamic models of sunitinib and pazopanib with clinical outcome , 2018.

N. Sarin. Cisplatin resistance is associated with altered signalling in NSCLC cells , 2017

O. Rose. Feasibility and Efficacy of a Collaborative Medication Management for Elderly, Multimorbid Patients , 2017

M. Kullmann. Identifying intracellular cisplatin interaction partners and assessing their contribution to cisplatin resistance, 2016

A. Wilmer. Entwicklung und Evaluation eines Best-Practice-Modells zur Erhöhung der Arzneimitteltherapiesicherheit bei ambulanten Krebspatienten , 2016

S. Kraff. Pharmakokinetische Dosisindividualisierung von Fluorouracil und Taxanen , 2016

R. Lenssen, geb. Heumüller. Arzneimitteltherapiesicherheit älterer, pflegebedürftiger Patienten in der stationären Versorgung unter besonderer Berücksichtigung der Schnittstellen im Behandlungsprozess , 2015

A. Hons, geb. Mowitz. Arzneimitteltherapiesicherheit bei älteren Patienten in öffentlichen Apotheken , 2014

H. Rühs. Pharmakokinetisch/ Pharmakodynamische Modellierung und Simulation unter Einbeziehung von Biomarkern der chemotherapieassoziierten Toxizität , 2013

L. Krolop. Adherence Management for Cancer Patients on Capecitabine , 2013

C. Mohn. Relevance of glutathione and MRP-mediated efflux for platinum resistance , 2013

F. Kanefendt. Analytik und Eignung von Biomarkern zur Vorhersage der Wirksamkeit von Sunitinib mit Hilfe von pharmakokinetischen/ pharmakodynamischen Modellen , 2013

G. Müller, geb. Vogel. Management von Arzneimittelinteraktionen in der öffentlichen Apotheke , 2013

V. Schneider. Beteiligung ATP-abhängiger Transportprozesse an der Resistenz gegenüber Platinkomplexen , 2012

N. Döhler, geb. Reineking. Integrating the Pharmacist into Cancer Medication Management , 2011

A. Lindauer. Pharmacokinetic / Pharmacodynamic Modeling and Simulation of Biomarker Response to Venlafaxine and Sunitinib Administration , 2011

A. Keunecke, geb. Drescher. Pharmakokinetische/pharmakodynamische Ansätze zur Dosisoptimierung antitumoraler Metallkomplexe , 2011

S. Ringsdorf, geb. Roth. Cost and Outcome Assessment of a Pharmaceutical Care Service for Cancer Patients treated with Capecitabine , 2010

I. Bosman, geb. Buß. Cellular Influx and Cytotoxicity of Oxaliplatin Analogues , 2010

S. Kaulich. Pharmazeutische Betreuung von Patientinnen mit Mammakarzinom in einem sektorenübergreifenden Versorgungsmodell , 2010

S. Retlich, geb. Dittberner. Population Pharmacokinetic and Pharmacodynamic Modelling and Simulation of Linagliptin, a Novel Dipeptidyl-Peptidas 4 Inhibitor for the Treatment of Type 2 Diabetes , 2010

S. Simons. Pharmazeutische Betreuung onkologischer Patienten unter Therapie mit Capecitabin , 2009

D. Garmann. Reaktivität und zelluläre Aufnahme albuminbindender Platinkomplexe und neuer Oxaliplatin-Analoga , 2007

C. Sirisangtragul. Pharmacokinetics and pharmacodynamics of intraventricularly administered etoposide in brain tumour patients , 2007

M. Westfeld. Nutzen einer Pharmazeutischen Betreuung von Mamma- und Ovarialkarzinom-Patienten , 2006

A. Junker. Klinische Untersuchungen zur Dosis-Konzentrations-Effektbeziehung von Oxaliplatin , 2006

S. Vezmar. Methotrexate-induced biochemical alterations of the folate and methyl-transfer pathway in the CNS , 2005

J. Zisowsky. Charakterisierung der Platinsensitivität von cisplatinsensitiven und -resistenten Tumorzellen , 2004 (im Rahmen des DFG-Graduiertenkollegs 677/1)

A. Becker. Einfluss von Methotrexat auf den Homocysteinstoffwechsel: Untersuchung an Leukämie- und Lymphompatienten , 2004

A. Liekweg. Pharmaceutical care for patients with gynaecological malignancies in the outpatient setting. A pilot study , 2004

A. C. Pieck. Pharmakokinetik und Platin-DNA-Adduktbildung von Oxaliplatin , 2004

K. Grasmäder. Pharmacokinetics of antidepressants and lithium. Variability and clinical implication for individual dose adaption , 2003

• Doctoral Dissertations
• DRSc Admissions
• Course Schedules
• Curriculum and Requirements
• Doctoral Program Cohorts
• Frequently Asked Questions
• On-Site / Distance Program
• Scholarships

2008 Cohort

2010 cohort, 2012 cohort, 2014 cohort, 2016 cohort, 2018 cohort, 2020 cohort, 2022 cohort.

PhD Dissertations

Zasim siddiqui.

Application of Interpretable Machine Learning Methods to Study the Disease Characteristics and Healthcare Expenditures in Hodgkin's Lymphoma

Degree - PhD Advisors  – Sabina Nduaguba, PhD

Trupti Dhumal

Intervention to Reduce Tobacco use among Prostate Cancer Patients and Informal Caregiver Dyads

Degree - PhD Advisors  – Khalid Kamal, PhD and Kimberly Kelly, PhD

Treatment Patterns and Clinical and Economic Burden in Patients with Merkel Cell Carcinoma (MCC): Statistical and Machine Learning Approaches

Degree - PhD Advisors  – Khalid Kamal, PhD

Rowida Mohamed

Health-Related Quality of Life and Risk Prediction in Idiopathic Pulmonary Fibrosis

Rudi Safarudin

Long-Term Prescription Opiod Use, Cancer Stage, and Economic Burden among Older Cancer Survivors with Non-Cancer Chronic Pain Conditions

Mohammad Ikram

Clinical and Economic Burden of Inflammatory Chronic Conditions among Adults in the United States: Evidence from Three Nationally Representative Surveys

Nazneen Shaikh

Incidence of Cancer, Depression, and Economic Burden of Prescription NSAIDS among Older Adults with Osteoarthritis: Statistical and Machine Learning Approaches

Degree - PhD Advisors  – Usha Sambamoorthi, PhD, and Traci LeMasters, PhD

Yifan Zhang

Screen Media Use Among Children and Adolescents - Applications of Supervised and Unsupervised Machine Learning and Sentiment Analysis

Amanda Stover

Breaking the Chain: Evaluating the Links Between Opioid Use Disorder, Overdose, and Suicide

Degree - PhD Advisor  – Erin Winstanley, PhD

Multimorbidity, Immune Checkpoint Inhibitor Use, and Healthcare Expenditures among Older Patients with Late-stage Melanoma

Degree - PhD Advisor  – Usha Sambamoorthi, PhD

Asthma-COPD Overlap among Elderly Medicare Beneficiaries: Economic Burden and Medication Adherence

Jayeshkumar Patel

Predictors of Cardiovascular and Gastrointestinal Disorders, Inappropriate Non-steroidal Anti-inflammatory Drug Use, and Dementia in Older Adults with Osteoarthritis

Degree - PhD Advisors  – Usha Sambamoorthi, PhD and Nilanjana Dwibedi, PhD

Khalid Alhussain

Applications of Machine Learning Methods in Health Outcomes Research: Heart Failure in Women

Chibuzo Iloabuchi

Association of Incident Cancer to Low-Value Care and Healthcare Cost Burden Among Elderly Medicare Beneficiaries

Degree - PhD Advisors – Usha Sambamoorthi, PhD and Nilanjana Dwibedi, PhD

Drishti Shah

Predictors and Health Outcomes of Treatment-Resistant Depression among Adults with Chronic Non-Cancer Pain Conditions and Major Depressive Disorder

Xiaohui Zhao

Adoption and Impact of Tele-mental Health on Healthcare Outcomes in the United States

Degree : PhD Advisor : Usha Sambamoorthi, PhD

Rashmi Goyat

Impact of Comorbidities on Diabetes and Hypertension Co-management and Healthcare Expenditures

Degree - PhD Advisors – Suresh Madhavan, PhD & Xi Tan, PharmD, Ph

Omar Attarabeen

Tobacco Use, Serious Smoking Cessation Attempts, and Interest in Lung Screening among Adults Muslims in the US   

Degree : PhD Advisor : Kimberly Kelly, PhD

Xu (Snow) Feng

Switching from Vitamin K Antagonists to Non-Vitamin K Oral  Anticoagulants, Drug-drug Interactions and Health Outcomes  among Working-age Adults with Atrial Fibrillation

Degree – PhD Advisor – Xi Tan, PharmD, PhD

Arijita Deb

Depression, Treatment Response to TNFi, and Economic Outcomes among Working-age Adults with Rheumatoid Arthritis

Degree:   PhD Advisor:   Usha Sambamoorthi, PhD

Doug Thornton

Transitions within Opioid Therapy and their Impact on Morbidity, healthcare utilization and Costs

Degree - PhD Advisor - Nilanjana Dwibedi, PhD

Ebtihag O.Alenzi

Impact of Diabetes Complications on Breast Cancer on Breast Cancer Screening, Diagnosis, and Prognosis among Elderly Women with Pre-existing Diabetes Using the SEER-Medicare Dataset

Degree - PhD Co-Advisors - S. Suresh Madhavan, PhD, Xi Tan, PharmD, PhD

Ishveen Chopra

Impact of incident cancer on CAD-related concomitant medication adherence, short-term health and economic outcomes among elderly Medicare beneficiaries with CAD with Incident Breast, Colorectal, and Prostate Cancer

Degree - PhD Advisor - Usha Sambamoorthi, PhD

The impact of Diffuse Large B-Cell Lymphoma on Primary Care and Costs of Chronic Conditions in Elderly Medicare Beneficiaries

Degree - PhD Advisor - Kimberly Kelly, PhD

Abdulkarim Meraya

The Dynamic Relationship between Economic Indicators and Health among Working-Age Adults

Degree - PhD Co-Advisors - Nilanjana Dwibedi, PhD and Usha Sambamoorthi, PhD

Monira Alwhaibi

Risk of Newly-diagnosed Depression, Treatment, and Its Economic Outcomes among Elderly Medicare Beneficiaries with Incident Breast, Colorectal, and Prostate Cancer

Autism Spectrum Disorders among Adults: Burden of Health Services Utilization and Expenditures

Degree - PhD Advisor - S. Suresh Madhavan, PhD

Parul Agarwal

Longitudinal Patterns and Economic Consequences of Emergency Department Visits among Medicaid Enrollees

Degree - PhD Co-Advisors - Thomas Bias, PhD and Usha Sambamoorthi, PhD

Impact of Chronic Conditions on Treatment, Cancer-and Non-Cancer Outcomes among Elderly Men with Incident Prostate Cancer

Traci LeMasters

An Analysis of Treatment Patterns, Receipt of Guideline-Concordant Care, and Survival Outcomes among Elderly Women with Non-Metastatic Breast Cancer Using the SEER-Medicare Linked Dataset

Mayank Ajmera

Multimorbidity, Management of COPD and Health Outcomes among Medicaid Beneficiaries

Rituparna Bhattacharya

Types of Co-existing Chronic Physical Conditions and Newly-diagnosed Depression, its Treatment and Economic Outcomes among Medicaid Beneficiaries with Type 2 Diabetes

Burden of Breast Cancer and Associated Health and Economic Outcomes in Elderly Women In West Virginia: Comparison with National Estimates

Sandipan Bhattacharjee

Burden of Illness among Elderly Individuals with Parkinson’s Disease

Pallavi Rane

Burden of Colorectal Cancer among the elderly Medicare Beneficiaries in West Virginia A comparative analysis with National data

Pramit Nadpara

Patterns of Lung Cancer Care and Associated Health Outcomes among Elderly Medicare Fee-For-Service Beneficiaries in West Virginia and in the United States

Colorectal Cancer Disease in Appalachia: Symptom Interpretation and Cancer Worry Predictors

Degree - MS Advisor - Kimberly Kelly, PhD

Access to Services, Quality of Care, and Family Impact for Caregivers of Children with Autism Spectrum Disorders: A National Perspective Using 2009-2010 Children with Special Health Care Needs (CSHCN) Survey

Degree - MS Advisor - S. Suresh Madhavan, PhD

Tricia Lee Wilkins

Healthcare Quality and Expenditure Benchmarks along the Continuum of Care: The Role of Primary Care Continuity and Community Healthcare Resources

Impact of Diabetes on Colorectal Cancer Outcomes

Degree - PhD Co-Advisor - Joel Halverson, PhD and S. Suresh Madhavan, PhD

Predictors of Adherence to Mammography Screening Guidelines and Preferences for Intervention Strategies in a Mobile Mammography Program

A National Study of Health Behaviors and Health related Quality of Life among Survivors of Breast, Prostate, and Colorectal Cancer Compared to Propensity Score Matched Controls, as well as Comparisons by Type

Abhijeet Bhanegaonkar

Patient Preferences for Benefits and Risks Associated with Disease Modifying Drug Treatments in Multiple Sclerosis

Gretchen Peirce

Controlled Drug Substance Use in West Virginia an Investigation into Doctor Shopping, Pharmacy Shopping, and Prescription Histories

Degree - MS Advisor - Michael Smith, PhD

Changes in Body Mass Index and Short-term Healthcare expenditures in a Medicare population

Degree - MS Advisor - Usha Sambamoorthi, PhD

Kimberly Bosworth Blake

Assessing the Influence of Coronary Heart Disease Knowledge, Perception of Personal risk, and Delay Discounting of Future Health on Diet and Physical activity

Degree - PhD Advisor - Carole V. Harris, PhD

Rahul Khanna

Burden of Care and Health-Related Quality of Life among Caregivers of Children with Autism Spectrum Disorder

Andrea Pfalzgraf

Self-Reported Physician Prescribing Behavior and Factors Related to Antidepressant Prescribing to Children and Adolescents with Major Depressive Disorder

Degree - PhD Advisor - Virginia G. Scott, PhD

Jarrett (Jay) Coffindaffer

Pharmacists and Tobacco Cessation Counseling: Attitudes and Beliefs, Impact of Cessation Training on Practice, and Feasibility of Training and Implementation into the Pharmacy Practice Setting

Degree - PhD Advisors - Irene Tessaro, DrPH & Lesley-Ann Miller, PhD

Murali Sundaram

Development and Validation Of A Diabetes-Specific Health State Classification System and Valuation Function Based On The Multi-Attribute Theory

Degree - PhD Advisor - Michael Smith, PhD

Anuja N. Roy

Impact of Co-morbid Insomnia on Health-Related Quality of Life and Patient Preferences in the Primary Care Setting

Predicting Physicians’ Intention to Measure Body Mass Index and Assessing their Identification and Evaluation Practices in Overweight Children and Adolescents

Degree - MS Advisor - Jan Kavookjian, PhD

Vivek Pawer

An Overview of Health Related Quality of Life Assessment in Multiple Sclerosis: Comparison of Measures, Identification of Predictors, and Use in Clinical Practice

Degree - PhD Advisor - Lesley-Ann Miller, PhD

Anna D'Souza

Clinically Relevant and Economic Outcomes of Maintenance Pharmacotherapy in Chronic Obstructive Pulmonary Disease (COPD)

Jay Coffindaffer

Colorectal Cancer: Cost-Effectiveness of Screening and Chemoprevention in Average Risk Patients

Degree - MS Advisor - Lesley-Ann Miller, PhD

Mariam Hassan

Evaluating Medication Utilization Patterns and Healthcare Outcomes in Patients receiving Antipsychotics

Khalid M. Kamal

Assessing the Cost-Effectiveness of Tumor Necrosis Factor Inhibitors and Prescribing Practices of Rheumatologists In Patients with Rheumatoid Arthritis

Quality of Life and Clinical Outcomes in Type 2 Diabetes Patients at the Primary Care Clinics of West Virginia University Hospital

Economic Evaluation of Prophylactic Antiemetic Regimens for Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV)

Ashish Joshi

Economic and Humanistic Impact of Medication Nonadherence in Patients with Asthma and Chronic Obstructive Pulmonary Disease

Iftekar Kalsekar

Epidemiological Burden of Depression and its Impact on Adherence to Oral Hypoglycemics and Related Economic Outcomes in Type II Diabetes Patients

Siddhesh Kamat

Validating a Measure Comparing Physician Readiness to Prescribe Beta Blockers, ACE Inhibitors, and Asprine Therapy to Post-Myocardial Infarction Patients

Ancilla Fernandes

Evaluating Utilization of Beta-blockers as Secondary Prevention for Post Myocardial Infarction in a Medicaid Population

Rohit Borker

Economic Evaluation of Primary and Secondary Prevention Strategies for Breat Cancer in a Medicaid Program

Lee Ann Thayer

Evaluating the Cost-Effectiveness of St. John's Wort versus Fluoxetine for the Treatment of Mild to Moderate Depression

Degree - MS Advisor - Virginia G. Scott, PhD

Economic Evaluation of Three Preventive Drug Therapies for Osteoporotic Fractures Among Women at Different Risk Levels

Evaluating Diagnostic and Treatment Modalities in the Management of Benign Prostatic Hyperplasia in the Veterans Administration Population

Degree - MS Advisor - Mayur Amonkar, PhD

Joshua Blevins

West Virginia's Perceptions and Use of Complementary Medicine

Degree - MS Advisor - David Nau, PhD

Aiman Momani

Assessment of the Impact of the West Virginia Medicaid's Prior Authorization Policy for NSAIDs on Chronic Patients: Economic and Humanistic Outcomes

Influences of Disease Severity on Health Beliefs and Treatment Adherence among HIV Patients

Steve Small

Psychological Influences on Reporting Medication Errors

Ambarish Ambegaonkar

Evaluation of the WV Medicaid Prior Authorization Program for Anti-Ulcer Medications

Mayur Amonkar

Matching Preventive Care Needs of Appalachians and Managed Care Strategies

Krithika Rajagopalan (Venkataraman)

Enhancing Medical Care Outcomes Through Patient Empowerment

Degree - PhD Advisor - Folakemi Odedina, PhD

Consumers' Perceptions of Drug-Management Strategies in Private Managed Care

Degree - MS Advisor - Folakemi Odedina, PhD & Alan Rosenbluth, PhD

Lionel Pinto

Expectation, Satisfaction, and Perceived Service Quality Paradigm in Asthma Patients' Assessment of Pharmacists' Services

Degree - MS Advisor - Folakemi Odedina, PhD

Assessing Pharmacist's Role in Primary Care A: A Strategy for Enhancing Rural Health in WV

Prasanna R. Gore

Childhood Immunizations in Rural WV: Identification of Immunization Barriers and Development of Persuasion Strategies

Rao Pippalla

An Impact Assessment of Pharmacist Counseling on Pharmaceutical Care of Hypertensive's Interrelationships of Compliance, Quality of Life, and Therapeutic Outcomes, with Some Policy Perspectives

Degree - PhD Advisor - David A. Riley, EdD

Explanation of Mothers' Illness Behavior Intentions, Attitudes, and Choice: An Application of the Theory of Reasoned Action

Degree - MS Advisor - Vijit Chinburapa, PhD

Credibility of the Sources of Information for Nonprescription Medicines

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Skaggs School of Pharmacy and Pharmaceutical Sciences

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PhD in Pharmaceutical Sciences

At CU Pharmacy, we’re training scientists who make an impact. Our doctoral program in pharmaceutical sciences is focused on solving problems. In particular, the program covers the formulation, synthesis, manufacturing, development, stability, biophysical analysis, characterization, delivery, and biodistribution of small molecules and biopharmaceutical agents.

Our goals are to provide the best training for students interested in pursuing careers in biopharmaceutical drug development; conduct high-quality research relevant to pharmaceutical biotechnology; offer innovative educational programs; and to support the biopharmaceutical industry, especially in Colorado.

Here, you’ll have access to a wide range of researchers and research equipment; cross-training with chemical engineers; essential non-scientific training in regulatory affairs, business topics and pharmacoeconomics; experience with real world compounds and research and development problems; and interaction with industry scientists.

We have a strong track record of setting our students up for success. Graduates of our program have advanced into successful careers as senior scientists in the pharmaceutical industry and academia. We’re here to make sure you have the training you need to pursue a career in drug and biopharmaceutical discovery, development or clinical optimization.

As part of the CU Anschutz Graduate School, all PhD students in good academic standing are guaranteed financial support.

All regular full-time departmental faculty in the Department of Pharmaceutical Sciences are formal members of the pharmaceutical sciences graduate program and can take students into their laboratories if appropriate.

On average, students in this program earn their PhDs in 5.5 years.

Applications for all doctoral programs are submitted electronically through the Graduate School of the University of Colorado Denver. After signing up for an account, select 'PhD' under the 'Academic Interests' menu and scroll down to 'Skaggs School of Pharmacy and Pharmaceutical Sciences' and select "PhD in Pharmaceutical Sciences."

Application requirements are:

• A completed Graduate School application and $50.00 application fee (Domestic) $75.00 application fee (International)
• A baccalaureate degree of arts or science from an accredited college or university with a minimum GPA of 3.0.** One (1) official transcript of all academic work completed to date with awarded baccalaureate degree. University transcripts from other countries must include a transcript evaluation from World Education Services ( WES ). Applicants who complete a transcript evaluation with WES will have their application fee waived automatically.
• All applicants for the program should complete a year of study in the following subjects: general chemistry, organic chemistry, calculus, biology, English and physics. In addition, courses in the following subjects are highly recommended to supplement the student's background: physiology, biochemistry, statistics, cell biology, physical chemistry, and computer science.
• Three (3) letters of recommendation from professors or research supervisors familiar with your aptitude for graduate study

Additionally:

• The GRE (Graduate Record Examination) is not required but is optional.
• The TOEFL is required of applicants for whom English is not their first language, Duolingo and IELTS also accepted (more information on this here )
• Please use 4875 as the Institution Code so that the test results will be sent directly to our institution
• Under special circumstances, deficiencies in important areas may be made up within the first year after entrance into the program. Normally, admission to the program will be based on an undergraduate GPA of 3.0 or better. However, applicants' recommendations, research experience and additional individual accomplishments will also be considered in the admissions process.

Application opens September 1, 2024. Applications will not be reviewed until all required materials have been received. The application deadline for Fall 2025 admission is December 1, 2024 for all students.

Admission to the program includes financial support via a stipend awarded on a 12-month basis. Based on the rules of the CU Anschutz Graduate School, all PhD students in good academic standing are guaranteed financial support.

Although a priority of the School of Pharmacy is to provide financial support to our graduate students, payment of stipend, tuition and any fees by the School of Pharmacy or by grants, contracts or gifts to the School of Pharmacy faculty is contingent upon satisfactory academic progress (as defined by the graduate school’s Pharmaceutical Sciences Graduate Student Handbook ) and completion of required teaching duties, core courses, research rotations, seminars, and examinations (as listed on the progress report form). We also reserve the right to review and adjust our funding policies at any time. All students are expected to work full-time toward program requirements for 12 months of the year.

Is the GRE required to apply?

What kind of students should pursue a phd degree in pharmaceutical sciences.

We are looking for bright, self-motivated people with degrees in chemistry, physics, biology, engineering, biochemistry, pharmacy and other related areas in biomedical science, who want a satisfying career connected with the pharmaceutical industry. This may involve working for a company, a federal laboratory, or an academic institution.

Just what does 'pharmaceutical sciences' mean?

Pharmaceutical sciences is a multi-disciplinary approach to solving problems associated with improving drug therapy for patients. It includes designing and synthesizing new drugs, developing new analytical methods to determine the purity and quality of therapeutic agents, finding better ways to deliver the drug to a patient, minimizing side effects, and assessing the activity and stability of drug compounds. Classically, pharmaceutical sciences was defined by the sub-disciplines of pharmaceutics, medicinal chemistry, pharmacology, and toxicology, but most modern research problems cross these traditional boundaries. In short, a graduate degree in pharmaceutical sciences is an ideal choice for anyone who wishes to work on developing new drug products and devices.

What makes the Pharmaceutical Sciences PhD program at the University of Colorado different than other PhD programs?

Emphasis on biotechnology.

Different graduate programs have different strengths. While one might come to the University of Colorado to pursue studies in any aspect of the pharmaceutical sciences, the real strength of our Pharmaceutical Sciences program lies in its emphasis on the use of quantitative, biophysical methods to address issues in pharmaceutical biotechnology. Pharmaceutical biotechnology describes a course of study that uses molecular biology, biophysical chemistry, and bioengineering methods to prepare and develop sophisticated therapeutic and diagnostic agents. These materials include recombinant proteins, vaccines, oligonucleotides, and gene therapy approaches. Students who pursue studies in pharmaceutical biotechnology might examine the stabilization of proteins and/or nucleic acids during storage, improved methods of drug delivery, analytical assay development, mutational effects on protein structure and function, molecular biology approaches to drug therapy, novel vaccines, bioprocessing, or formulation development. Students are required to take a core curriculum that reflects these areas of research. This effort has been strengthened by the formation of the Center for Pharmaceutical Biotechnology, which is centered on a partnership between chemical engineering at the University of Colorado at Boulder and the School of Pharmacy.

The Opportunity to Work on 'Real World' Problems

Today's biotechnology products are quite complex. Therefore, it is advantageous for students to have the opportunity to work with therapeutic agents that are in development or on the market. Due to the generosity of industrial collaborators, students in our program have access to recently-discovered drug candidates before these compounds are marketed as commercial pharmaceuticals. Each year, industrial sponsors provide millions of dollars worth of compounds for research purposes.

Partnering with Industry

In order to facilitate interactions, we have established the Center for Pharmaceutical Biotechnology, which promotes graduate education and research opportunities by partnering with the pharmaceutical biotechnology industry. These interactions often result in the student participating in an industrial internship with a scientific mentor from the company.

Training in Financial and Legal Aspects of Pharmaceutical Sciences

Since most of our students ultimately are employed in a highly regulated industry affected by market pressures, all of our graduate students take courses covering regulatory affairs (i.e., the drug approval process), patent law, intellectual property issues, pharmaceutical marketing, and financial analysis. These skills are essential, but rarely found in other PhD programs. For students who wish to focus on these issues, we have established a separate PhD track in pharmaceutical Outcomes within the Pharmaceutical Sciences PhD program. Students interested in pursuing Outcomes research should view the Outcomes Research webpage.

What are the job prospects for a graduate with a PhD degree in the pharmaceutical sciences?

Considering the unique strengths of our program, someone who is successful and productive in our program will find a high demand for their talents. Most of our students find jobs with large pharmaceutical companies or smaller biotechnology enterprises. Typically, our students have multiple job offers awaiting them upon graduation.

Required Pharmaceutical Sciences Program Courses

Representative elective courses.

Through the pharmaceutical sciences graduate program, our goal is to educate pre-doctoral students to develop independent research careers in pharmaceutical sciences with a basic, clinical or pharmaceutical outcomes emphasis. Upon completion of the graduate program, our students use their training to make a difference in academia, industry or government. The learning objectives for the graduate program are:

• Demonstrate a basic knowledge of central concepts in the biomedical sciences.
• Understand the current concepts in basic and clinical pharmaceutical sciences.
• Read and critically evaluate the scientific literature.
• Formulate hypotheses based on current concepts in the field and design, conduct, and interpret their own research projects.
• Present research results in peer-reviewed publications and in a dissertation.
• Communicate research results effectively through oral presentations at scientific seminars, conferences, and other venues.

School of Pharmacy Graduate Degree Requirements

The following are specific rules approved by the graduate faculty of the School of Pharmacy for graduate studies leading to doctor of philosophy degree in toxicology. All other requirements for these degrees will follow the guidelines of the Graduate School, which can be found in the Pharmaceutical Sciences Graduate Student Handbook . The student carries the major responsibility of meeting the rules of the School of Pharmacy and the Graduate School. Failure to meet the following rules and guidelines may result in delay of graduation. ​

Student Progress Reviews

Each student will meet at least every six months with their temporary/thesis committee (starting the week before classes begin in the first year) in order to keep the committee apprised of all aspects of the student’s progress. A progress report form listing the requirements will be maintained in the School of Pharmacy graduate program file for each student.

It is the responsibility of the student to arrange meetings with his/her committee, and ensure that the deadlines listed on the progress report form are fulfilled. After fulfilling each requirement, it is required that the student make certain that the progress report form is updated by the committee chair.

Student Committees

Temporary Committees

The graduate program committee will appoint temporary committees for new students to serve for the first year. Each committee will consist of at least two full-time faculty from the School of Pharmacy. Each student will meet with their temporary committee the week before classes begin, and in March and September of the first year of the graduate program.

Thesis Committees

Students will choose the chair of their thesis committee subsequent to the successful completion of the preliminary examination and selection of a major advisor (at the end of the first year). The student’s major advisor cannot serve as chair of the thesis committee. The student together with the chair and major advisor will choose other members from the faculty of the school and at least one from outside the school who will serve on the thesis committee.

Thesis committees must consist of at least five faculty members, and will meet with the student every six months, starting in September at the beginning of the student’s second year. The graduate program director must approve the make-up of the thesis committee. The graduate program director will fill vacancies as they arise or make replacements when necessary, with consideration given to student/advisor recommendations.

Thesis committees shall evaluate the student’s progress to ensure that she or he has made satisfactory progress since the previous meeting. Upon calling the meeting to order, the Committee Chair will ask the student to leave the room to obtain feedback from the advisor regarding student progress. Upon completion, the student will be asked to return to the room and the thesis advisor will leave the room to obtain private feedback from the student regarding issues that might exist in terms of interactions with the advisor. It is also the responsibility of the committee chair to complete an on-line evaluation form summarizing the student’s progress. In case of a non-satisfactory performance, steps required to rectify the situation should be suggested in the report.

Doctor of Philosophy

In order to graduate, a student must satisfactorily complete the requirements described in A through H below as well as adhering to all requirements of the CU Anschutz Graduate School as defined in the Pharmaceutical Sciences Graduate Student Handbook .

A. Coursework and General Requirements

A program of study with required core courses will be designed by the chair of the temporary/thesis committee to accommodate the student’s long-range goals, possible undergraduate deficiencies, immediate research interests and the requirements of the Graduate School. A minimum of 30 semester hours of courses numbered 5000 or above is required for the degree. In addition to the coursework and requirements described below, students are expected to attend all seminars associated with the graduate program in pharmaceutical sciences. Also, each year the Department of Pharmaceutical Sciences hosts a research retreat. Attendance at the retreat is mandatory, unless the program director permits the absence for overriding personal reasons. A presentation (oral or poster) by each student at the retreat is required.

B. Research Rotations

All PhD students must satisfactorily complete one research rotation in each of the fall and spring semesters of their first year. It is expected that the student will meet with his/her temporary committee the week before classes start in the fall semester to determine an appropriate research rotation for the ensuing fall semester. A research rotation is one semester in length, and the student must be housed in the lab in which the rotation is conducted. The student will present his/her research findings from each rotation in seminars (20 mins) to the graduate faculty (date arranged in advance by the director of the pharmaceutical sciences graduate program). In cases where a student opts for a third research rotation in the summer, a third rotation seminar is not required.

C. Seminars

In addition to rotation seminars and semiannual presentations to the thesis committee, all students enrolled in the program must present a thesis seminar to the Department of Pharmaceutical Sciences that describes the findings from his/her thesis research. The thesis seminar is normally performed at the end of their PhD program.

D. Preliminary Examination

Each student will be required to undergo a preliminary examination during the summer of their first year in the program. This examination will consist of two half-day written examinations during the summer session. Selected faculty will contribute questions to the exam primarily focusing on the first year’s coursework. Students will be given the general topic areas for the exam questions at least one month prior to the examination date.

The director of the graduate program will be responsible for coordinating and administrating the examination. The preliminary examination is intended to test the student’s assimilation and understanding of material presented in coursework, and assess his/her ability to complete a doctoral–level course of study. It is expected that students will satisfactorily answer each question, but students are permitted to remediate one question if his/her answer is judged to be inadequate by the faculty member providing the question. In these instances, the individual faculty member will decide what constitutes appropriate remediation, and completion of remediation will be reported to the graduate program chair. Students that unsatisfactorily answer two or more preliminary examination questions will be dismissed from the graduate program.

E. Comprehensive Examination

The comprehensive examination will be administered by the chair of the student’s thesis committee. This committee must include the major advisor and at least four other members of the graduate faculty. At least one of the five members must be from outside the School. The comprehensive examination will serve as the formal test for admission to candidacy for the PhD degree and can only be taken after completion of 30 semester hours of graduate credit. The comprehensive examination will be completed by September 31 of the third year, after formal coursework is completed.

The examination shall consist of a written examination as well as an oral examination. The suggested format of the examination is for each faculty member to administer a separate written examination that can be completed within one day. The student should meet with members of the thesis committee individually to discuss the topic areas for the comprehensive examination. After the written portion of the comprehensive exam, students should meet with each member of the thesis committee to discuss the student’s performance on the written questions. It is expected that any weaknesses will be addressed in the oral portion of the exam that is to be taken within two weeks after completion of the written portion. Possible outcomes of the comprehensive examination are in accord with the CU Anschutz Graduate School rules and are Pass, Pass with Conditions, and Fail. A failed student may not continue in the program.

F. Thesis Proposal

In order to facilitate the partnership between the student and his/her Thesis Committee, students are required to submit a written thesis proposal that will subsequently be presented orally to the thesis committee. The written proposal is typically approximately 10 pages in length (single-spaced, not including references), and submitted to the thesis committee at least two weeks prior to the oral presentation. The precise format of the written proposal is left to the committee, but it should be a brief, well written document describing the overall research plan for the student’s thesis and include relevant preliminary data. It is expected that the student’s major advisor will have previewed and edited the written proposal prior to its distribution to the rest of the thesis committee. The oral presentation of the thesis proposal to the thesis committee must be completed by March 31 of the student’s third year in the program.

After presentation and approval of the thesis proposal, the student will update the members of his/her thesis committee on the progress toward completion of the thesis research at the semiannual meetings in March and September of each year. It is expected that members of the thesis committee will provide feedback and discuss potential problems at these semiannual meetings.

G. Thesis Research

All PhD candidates will be required to satisfactorily complete a research thesis. This work should be of sufficient scope and quality to result in a significant contribution to the literature. Students must successfully complete a minimum of 30 semester hours of thesis work. See the rules of the Graduate School describing time restrictions for submitting the finished thesis. A copy of the thesis must be submitted to the student’s thesis committee at least two weeks prior to the thesis defense. It is expected that the student’s major advisor will preview and edit the thesis prior to distribution to the rest of the thesis committee.

H. Thesis Defense

After submission of the thesis to the thesis committee, a seminar describing the thesis research will be presented by the student to the Department of Pharmaceutical Sciences. Immediately following the oral presentation and questions from the attendees, the student will be examined separately by his/her thesis committee. Any changes to the thesis must be approved by the Thesis Committee prior to submission of the final thesis to the Graduate School. Although it is fully expected that problems with the thesis research will be addressed prior to the thesis defense, the thesis committee can require further research to be conducted before final approval of the thesis.

Summary schedule of degree requirements:

• First Year: Research rotations (2), rotation seminars (2), coursework, preliminary exam, selection of major advisor.
• Second Year: Commence thesis research, selection of thesis committee, coursework.
• Third Year: Comprehensive examination, thesis proposal.
• Prior to Completion: Submit written thesis to thesis committee, thesis defense.

Stipend, Insurance, Tuition and Fees

Although a priority of the School of Pharmacy is to provide financial support to its graduate students, stipend, tuition and fees for graduate studies in the School of Pharmacy are the sole responsibility of the student. Payment of stipend, tuition and any fees by the School of Pharmacy or by grants, contracts or gifts to the School of Pharmacy Faculty is contingent upon satisfactory academic progress (as defined by the Pharmaceutical Sciences Graduate Student Handbook ) and completion of required core courses, seminars, research rotations and examinations.

The School of Pharmacy also reserves the right to review and adjust its funding policies at any time. Stipends are awarded on a 12-month basis. All students are expected to work toward program requirements for 12 months of the year.

Probationary Status and Suspension

Continuation in the pharmaceutical sciences graduate program is dependent upon satisfactory academic progress as defined by:

• Timely and satisfactory completion of pharmaceutical sciences graduate program requirements (A-H above).
• Adherence to all policies, rules and regulation of the School of Pharmacy.

Students who do not remain in good graduate standing (3.0 GPA or above) or maintain satisfactory academic progress are placed on academic probation. Probation and suspension policies are described in the Pharmaceutical Sciences Graduate Student Handbook .

Payment of stipend, tuition, insurance and fees for a student while on academic probation is at the discretion of the graduate program committee.

Rajesh Agarwal PhD

Tom Anchordoquy BS, MA, PhD

Peter Anderson PharmD

Christina Aquilante PharmD

David Bain PhD

John Carpenter PhD

Carlos Catalano PharmD, PhD

Shaodong Dai PhD

Melanie Joy PharmD, PhD

Uday Kompella PhD, FARVO, FAAPS

Daniel LaBarbera PhD

Krishna Mallela PhD

Vanessa Phelan PhD

Philip Reigan PhD

Nichole Reisdorph PhD

Laura Saba PhD

Robert Scheinman PhD

Dmitri Simberg PhD

For questions regarding graduate school programs contact:.

Isabella Jaramillo Email:  [email protected]     Phone:  303.724.7263 ​​​​​

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Thesis proposal

Thesis proposal courses.

In Pharmacy, the MSc thesis proposal and the PhD thesis proposal are required courses.

• PHARM 601 is the MSc thesis proposal course; MSc students register for this course in term 2.
• PHARM 616A is the PhD thesis proposal course for students who have not ever completed PHARM 601; students register for this course in term 3
• PHARM 616B is the PhD thesis proposal course for students who transferred from the MSc in Pharmacy; students should register for this course in the same term they they begin their PhD after being approved for transfer. 

The objective is for students to learn how to use the literature to stimulate in-depth thinking about the basis of their thesis research project and to encourage the development of their scientific oral presentation skills, to best prepare and present their research objectives in written and oral form.

Thesis proposal course requirements

In addition to preparing a written and oral presentation of their proposed research, to receive course credit students must:

• Involves completing online modules as well as participation in an in-person session co-hosted by the Pharmacy Liaison Librarian and an Advisor from the Writing and Communication Center.
• Provides background on literature searching, citation and proper management of references as part of the preparation of the thesis proposal.  
• The workshop is offered once per term, as needed. 
• Students should attend in their first term, before they register in the thesis proposal course
• Workshop dates are communicated via email and/or Outlook calendar invitation.
• Attend a one-on-one appointment with the Pharmacy Liaison Librarian to discuss. research strategies and reinforce academic integrity.
• Attend two thesis proposals (or one thesis proposal and one thesis defence) by other students in Pharmacy, before their own thesis proposal examination.
• MSc students must hold the thesis proposal examination before the end of their second term.
• PhD students must hold their thesis proposal examination within their first year of the PhD program, before the end of term three.
• Any student requiring more time must request an extension, subject to the approval of the Graduate Officer.
• Prepare and submit for examination both a written proposal and oral presentation of the proposal.

The advisory committee appointment must be approved and the first meeting of the committee held before the proposal examination can take place.

Thesis proposal guidelines

The thesis proposal should outline the reasons for undertaking the project, concisely survey the relevant literature, present a detailed description of the methodology to be used, and outline any preliminary results.

• Generally, a report of 30-40 pages is required, not including figures, legends, or references. Excess pages may be removed or disregarded.
• Additional material including raw data may be included in appendices, if needed.
• The completed thesis proposal should be double-spaced with 1-inch margins and size twelve font.
• The style of the report should follow conventions familiar to the area of research of the student. At minimum, the written thesis proposal report should include the components indicated in the following table.

Scheduling the thesis proposal examination

Follow the steps below when you are ready for your proposal examination:  

• Refer to "what to expect at the thesis proposal" to determine how much time you should book for your proposal (two hours is generally enough time for an examining committee with three examiners; additional time may be required for deliberation).
• Select two possible dates and times and ask your committee to save those dates until the exam is confirmed.
• If you did not sign up for the appropriate course (Pharm 601 or Pharm 616A/B) during the course enrolment period, complete and submit the Graduate Studies course drop/add form at the same time as submitting the meeting request form. 
• book a room, if required, and send the calendar invitation to confirm the date and time
• arrange the examination chair
• prepare the examination report and distribute it to the chair and members of the examining committee, along with the grading sheet
• set up day of IT support (for in person and hybrid exams only).
• schedule a 15-30 minute IT training session/proposal practice ahead of the proposal exam, to ensure IT has the equipment/adapters necessary for the exam and not scrambling on the day of your exam.
• Your IT request should be sent no earlier than one week prior to the test/training date.
• Submit an electronic copy of the (written) thesis proposal to each member of the examination committee and cc the graduate coordinator at least 10 business days ahead of the proposal examination date. Late submission will result in the rescheduling of your examination unless you have received permission from all members of the examining committee.  

Pharmacy blackout dates

Pharmacy has blackout dates for thesis proposals and comprehensive examinations. Blackout dates exist to allow maximum participation in the Pharmacy program and to minimize scheduling conflicts for examination chairs and committee members. Exceptions may be considered on a case-by-case basis. 

for hybrid and in person exams

Ready to schedule your exam?

What to expect at the thesis proposal examination.

The oral examination will take approximately 2 hours and should consist of a 25-30 minute PowerPoint presentation, followed by questions from the examination committee.  Due to time limitations for the oral examination, it may not be possible to cover all aspects of the proposal in the presentation.

The question period will involve a first round of questions from the committee lasting 10-15 minutes per committee member, followed by a second round of questions in the same format but usually only 5-10 minutes each. Questions may be taken from the audience and the student's response to questions from the audience may be considered in the evaluation of the student. 

Thesis proposal examinations are not ‘public’ in the same sense that thesis defences are and are not announced throughout the Faculty of Science.  The administrative coordinator will inform pharmacy graduate students of upcoming proposal presentations so they may attend toward fulfillment of the thesis proposal course requirements.  External friends and relatives are not permitted to attend. 

Following the oral examination, the audience and students are excused so the committee can deliberate. All examiners should be present for deliberation.  After deliberation, the student is invited back into the room to hear the results of their exam. Students will receive a summary of their final grading assessment once the report has received approval. 

Assessment of the thesis proposal

Assessment of the thesis proposal is twofold:

• The written proposal report and the oral presentation and discussion are each marked separately and independently by three or more committee members (the examining committee) following the grading scheme below. The final course grade is calculated by averaging the total scores of all examining committee members.
• The assessment of whether the student has met the standards for the proposal and for progress in their graduate program overall is recorded on the thesis proposal examination report. All members of the thesis proposal examination committee participate in grading and in the assessment of the student's overall progress.

Thesis proposal grading scheme

Students must complete all graduate courses with a final mark of 70% or greater, as noted in the Academic Calendar.

Thesis proposal examination report

The decision as to whether standards for the proposal and progress to date are met is made by the committee, recorded by the chair, and reported to the Faculty of Science usingthesis proposal examination report. Committee members assesses the student's position by indicating 'excellent', 'satisfactory', or 'unsatisfactory', in the following areas:

• Understanding of the material: Candidate shows adequate depth and scope of knowledge for the current stage of the project.
• Ability to handle discussion: Candidate is able to understand the pitfalls and interpretation of the project.
• Research progress: Student demonstrates a general level of progress considering the complexity of the work and practical difficulties.

Performance and standards of research concerning expectations for the degree level as well as they pertain to timely completion of the degree are indicated with a yes/no response.  Any questions, concerns, difficulties or corrective measures required by the student must be recorded in the comments sections of the report; the committee must specify an action plan outlining what the student is expected to do by a specified date. 

Home > FACULTIES > Physiology and Pharmacology > PHARMTOX-ETD

Pharmacology and Toxicology Theses and Dissertations

This collection contains theses and dissertations from the Department of Pharmacology and Toxicology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

Theses/Dissertations from 2017 2017

The Effects of Acetylenic Tricyclic Bis-(Cyano Enone) on Cell Migration , Eddie Chan

Regulation of Cardiac Hypertrophy and Metabolism by Regulator of G Protein Signalling 2 (RGS2) , Katherine N. Lee

Theses/Dissertations from 2016 2016

Effects of Prenatal Exposure to Bisphenol A on Fetal Lung Development , Ayten Hijazi

Regulation of E2F1 in Keratinocytes During UV-Damage and Differentiation , Randeep K. Singh

Theses/Dissertations from 2015 2015

Quantitative Estimation of P-glycorptein-Mediated Drug Transport by Mechanistically Modeled Intrinsic Clearance , Alex D. Morgan

Epidermal Growth Factor Receptor in Joint Health and Osteoarthritis , Michael A. Pest

Regulation of Hepatic Drug Metabolizing Enzymes in Chronic Kidney Disease , Thomas J. Velenosi

Theses/Dissertations from 2014 2014

American Ginseng Modulation of Immune Function and Phytochemical Analysis , Chike G. Azike

Analysis of the Vascular Phenotype of the ENT1-null mouse , Keisha A. Best

Cortisol and Testosterone in Hair as Biological Markers of Systolic Heart Failure , Justin Chan

Regulation of the High-Affinity Choline Transporter Activity and Trafficking in Alzheimer’s Disease-Related Pathological Conditions , Leah K. Cuddy

Erythropoietin and Chronic Kidney Disease Alter Hepatic Expression of Cytochrome P450 Enzymes and Drug Transport Proteins , David A. Feere

The Role of c-Kit Receptor Tyrosine Kinase in Beta-Cell Proliferation, Function and Survival , Zhi Chao Feng

The Effects of Atypical Protein Kinase C on TGFβ Signalling , Adrian D. Gunaratne

Investigating Risk Factors for Pediatric Opioid Morbidity and Mortality , Lauren E. Kelly

Role Of Nitric Oxide In Embryonic Heart Development And Adult Aortic Valve Disease , Yin Liu

The ATP2C2 Gene as Transcribed from a Novel Transcriptional Start Site in Pancreatic Acinar Cells , Caitlin M. Sullivan

Effect of Ascorbate on Coagulation and Fibrinolytic Factors in the Septic Microvasculature , Scott Swarbreck

In Vitro Functional Analysis Of Novel Single Nucleotide Polymorphisms In OATP1B1 And Potential Clinical Relevance , Zhiyuan P. Yin

Theses/Dissertations from 2013 2013

Role of iNOS in septic pulmonary microvascular endothelial cell activation , Zahra Asad

ER stress coupled pannexin channel activation via STIM proteins , Ankur Bodalia

Pharmacogenetics of Oral Anticoagulants and Antiplatelets , Inna Gong

N-acetylcysteine as a chemoprotectant against ifosfamide nephrotoxicity; from mechanism to prevention , Lauren Hanly

Fetal and Neonatal Exposure to Nicotine Augments Hepatic Fatty Acid Synthesis in Rat Offspring Long-Term , Noelle L. Ma

Reorganization of inhibitory synapses in experimental epilepsy , Emily J. Pollock

Mechanism of Ascorbate Protection Against Sepsis-Induced Capillary Blood Flow Impairment , Dan Secor

Theses/Dissertations from 2012 2012

Statin Transport by Hepatic Organic Anion-Transporting Polypeptides (OATPs) , Marianne K. DeGorter

The Role of Drug Transporters in Statin-Induced Myopathy , Michael J. Knauer

The role of GRK2 in hypertension and regulation of GPR30 , Bonan Liu

Human Equilibrative Nucleoside Transporter Subtype 1: Structure-Function Analysis Using Cysteine Mutagenesis and Thiol Modifying Techniques , Jamie Park

Methodological Challenges and Clinical Applications of Hair Cortisol Analysis , Evan W. Russell

Intestinal and hepatic drug transporters and their role in the disposition of lipid-lowering drugs , Ute I. Schwarz

Molecular Mechanisms of Cell Migration Inhibition by Synthetic Triterpenoids , Ciric Chi Wing To

Characterization of EIF2Be and Its Interaction with RGS2 , William H. Xue

Theses/Dissertations from 2011 2011

Purine Transport and Metabolism in Microvascular Endothelial Cells , Derek B J Bone

Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications , Abdelbaset A. Elzagallaai

Regulation of G Protein Signaling by GoLoco Motif Containing Proteins , Peishen Zhao

Theses/Dissertations from 2010 2010

Pharmacokinetics and Therapeutic Uses of Mesna , Murray J. Cutler

Regulation of DNA Damage Processing by Covalent Modification of Thymine DNA Glycosylase , Ryan D. Mohan

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©1878 - 2016 Western University

Nikki Werkman: 2023

Ard van Veelen: 2023

Pieter Glerum: 2023

Judith de Ruijter - van Dalem: 2022

Richard Houghton: 2021

Shahab Abtahi, 2021

Olorunfemi A. Oshagbemi, 2019

Lotte Knapen, 2019

Roy de Jong, 2019

Carlota Mestres Gonzalvo, 2018:

Yannick Nielen, 2018,

Meta Diekstra, 2017, Thesis cum laude

Henk Scheepers, 2017

Abby Yang Yu, 2017

Annemariek Driessen, 2017

Bart Spaetgens, 2017

Carlota Mestres Gonzalvo, 2018: Medication Optimisation: Methodological aspects and new strategies.

Yannick Nielen, 2018, Osteoarthritis: association with diabetes mellitus, and treatment-related outcomes.

Meta Diekstra, 2017, Thesis cum laude, Pharmacogenetics of sunitinib in metastatic renal cell carcinoma

Abby Yang Yu, 2017, T owards understanding interchangeability of generic drugs

Bart Spaetgens, 2017, Assessing the impact of gout: validation and understanding outcomes

 Henk Scheepers, 2017,  Pharmacy Preparations -   European quality standards and regulation.

Annemariek Driessen, 2017, Unintended Effects of Anti-Hyperglycaemic Drugs Studied in Population-Based Cohorts

Michiel Haeseker, 2015, Adequate antimicrobial treatment in elderly patients

Dennis Wong, 2015.   Thiopurines in Inflammatory Bowel Diseases

Anne-Marie J.W. Scheepers-Hoeks, 2014.  Alert methods as succes factors.   Influencing effectiveness of a clinical decision support system in clinical practice.

Paddy K.C. Janssen, 2014. Time will tell; genetic influences on ejaculation time.

Nicole M.L Veldhorst-Janssen, 2013. Intranasal delivery of rapid acting drugs.  Studies of pharmacokinetics, effect, tolerability, and satisfaction.

Hein van Onzenoort, 2012, Treatment adherence in hypertension.   Methodological aspects and new strategies.

Sander Croes, 2012. Staphylococcus aureus biofilm

Joyce Pullen, 2007. Pharmacokinetics and dosing of antibiotics in neonates

Frank de Vries, 2007. Unintended Effects of Inhaled Corticosteroids: Disease or Drugs?

Hendrikus Boersma, 2006. Annexin A5: pharmacology, radiopharmaceutical aspects, and cell death imaging

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Pharmacoepidemiology and Clinical Pharmacology

Over the years many students have graduated from our division, writing wonderful PhD theses. Looking through the names of the graduates, familiar names pop up. Some have gone on to become professors, employees of the division or influential voices in the research community. Several of them will have gone on to supervise the theses of later students, including PhD students of other universities throughout the Netherlands.

To celebrate the work of these students over the years, an exhaustive overview of the published PhD theses can now more easily be read here on the website. In the Utrecht University Repository many of these PhD theses can be read in their entirety. 

An overview of these PhD theses is included down below, organized by year of graduation. 

PhD students at our division

The role of science, practice and education in building capacity for pharmacy and pharmaceutical sciences Kusynova, Z. Supervisory team: prof. dr. A.K. Mantel-Teeuwisse, prof. dr. H.G.M. Leufkens, dr. H.A. van den Ham Utrecht University (Faculty of Science), 10 Jan 2024. Read on Utrecht University Repository

On The Edge Of HTA: Shaping the boundaries across borders and stakeholders to prepare HTA for future complex medicines Hogervorst, M.A. Supervisory team: prof. dr. A.K. Mantel-Teeuwisse, dr. ir. W.G. Goettsch, dr. R.A. Vreman. Utrecht University (Faculty of Science), 12 Jan 2024. Read on Utrecht University Repository

Innovating Health Technology Assessment Methods: Barriers and Enablers illustrated using Qualitative and Quantitative Methods on Real-World Data Jiu, L. Supervisory team: dr. ir. W.G. Goettsch, prof. dr. A.K. Mantel-Teeuwisse, dr. J. Wang. Utrecht University (Faculty of Science), 28 Mar 2024. Read on Utrecht University Repository

Relevance of pharmacological boosters in the disposition of oral anticancer drugs: Mouse models Loos, N. Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 10 Apr 2024.

Improving patient access to valuable new pharmaceuticals: Working towards and evidence ecosystem in healthcare Kalf, R.R.J. Supervisory team: dr. ir. W.G. Goettsch, dr. D.M.J. Delnoij, dr. prof. M.L. Bouvy. Utrecht University (Faculty of Science), 13 Apr 2024. Read on Utrecht University Repository

The CombiConsultation: Patient-centred pharmaceutical care by interprofessional collaboration Meijvis, V.A.M. Supervisory team: prof. dr. M.L. Bouvy, prof. dr. N.J. de Wit, dr. H.F. Kwint, dr. M. Heringa. Utrecht University (Faculty of Science), 15 May 2024. Read on Utrecht University Repository

Forging new paths in access to medicines research: Towards equitable access for all Joosse, I.R. Supervisory team: prof. dr. A.K. Mantel-Teeuwisse, dr. prof. F. Suleman, dr. H.A. van den Ham Utrecht University (Faculty of Science), 27 May 2024. Read on Utrecht University Repository

Globalization of orphan drug development: integrating science, regulation, and access Coste, E. Supervisory team: prof. dr. H.G.M. Leufkens, dr. H.A. van den Ham Utrecht University (Faculty of Science), 15 Jul 2024. Read on Utrecht University Repository

External PhD students supervised by staff of our division

We can only keep hoping: Effects of News about Innovative Diabetes Therapies on Patients’ Emotional and Cognitive Responses Vehof, J.H. Supervisory team: prof. dr. H.H.J. Das, prof. dr. J.M. Sanders, dr. E.R. Heerdink. Radboud Universiteit, 16 Jan 2024. Read on HBO Kennisbank

Strategies for sustainable medication use: Waste or wasted opportunities Smale, E.M. Supervisory team: prof. dr. B.J.F. van den Bemt, prof. dr. A.C.G. Egberts, Dr. C.L. Bekker, dr. E.R. Heerdink. Radboud Universiteit, 8 May 2024. Read on GreenThesis

Real-world treatment outcomes in muscle-invasive and metastatic bladder cancer; Towards better use of outcome data Reesink, D.J. Supervisory team: prof. dr. S. Horenblas, prof. dr. D.H. Biesma, dr. H.H.E. van Melick, dr. van de Garde, E.M.W. Utrecht University (Faculty of Science), 6 Jun 2024. Read on Utrecht University Repository

Metabolomics in community-acquired pneumonia: Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia. den Hartog, I. Supervisory team: prof. dr. J.G.C. van Hasselt, prof. dr. T. Hankemeijer, dr. van de Garde, E.M.W. Leiden University, 16 Sep 2024. Read more about it on the Leiden University website

Knowing me, knowing you: the evolution of HTA practice and approaches from the perspectives of HTA Agencies and pharmaceutical industry Wang, T. Supervisory team: prof. dr. M.L. de Bruin, prof. dr. H.G.M. Leufkens, dr. ir. W.G. Goettsch, dr. N. McAuslane. Utrecht University (Faculty of Science), 11 Jan 2023. Read on Utrecht University Repository

In vitro and in silico optimization of oral taxane therapy van Eijk, M. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. A.D.R. Huitema, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 6 Feb 2023. Read on Utrecht University Repository

Target site bioanalysis and pharmacokinetics of antileishmanial drugs Roseboom, I.C. Supervisory team: prof. dr. J.H. Beijnen, dr. T.P.C. Dorlo. Utrecht University (Faculty of Science), 22 Feb 2023. Read on Utrecht University Repository

Monitoring for adverse drug reactions in children and adolescents treated with antipsychotic drugs Minjon, L. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. E.F. van den Ban. Utrecht University (Faculty of Science), 3 Apr 2023. Read on Utrecht University Repository

TNFα inhibitor treatment trajectories: learnings on biosimilars from clinical practice Meijboom, R.W. Supervisory team: prof. dr. A.C.G. Egberts, dr. T.J. Giezen, dr. H. Gardarsdottir. Utrecht University (Faculty of Science), 2 Oct 2023. Read on Utrecht University Repository

Statin treatment in the ageing population Lefeber, G.J. Supervisory team: prof. dr. A. de Boer, prof. dr. M.L. Bouvy, dr. H. Koek, dr. W. Knol. Utrecht University (Faculty of Science), 2 Oct 2023. Read on Utrecht University Repository

Pharmacological and physiological roles of the carboxylesterase 1 enzyme complex Gan, C. Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 13 Nov 2023. Read on Utrecht University Repository

Contextualising access to essential medicines: Lessons learned from East and Southern Africa Ooms, G.I. Supervisory team: prof. dr. A.K. Mante-Teeuwisse, dr. H.A. van der Ham, dr. T. Reed. Utrecht University (Faculty of Science), 13 Dec 2023. Read on Utrecht University Repository

Biomarkers for individualizing platinum-based therapy of patients with non-small cell lung cancer de Jong, C. Supervisory team: Prof. dr. A.C.G. Egberts (Utrecht University), dr. V.H.M. Deneer (Utrecht University), dr. G.J.M. Herder (Meander MC). Utrecht University, 23 Mar 2023. Read on Utrecht University Repository

Towards tailored medication self-management: Needs of and support for patients with limited health literacy Visscher, B. Supervisory team: Prof. dr. J. Rademakers (Maastricht University) and dr. E.R. Heerdink (Utrecht University). Maastricht University, 17 Apr 2023. Read on Maastricht University website

Antiplatelet treatment in acute myocardial infarction: from routine treatment to genotype guided personalized medicine Bergmeijer, T.O. Supervisory team: Prof. dr. J.M. ten Berg (Maastricht University), dr. V.H.M. Deneer (Utrecht University), dr. C.M. Hackeng (Antonius Hospital). Maastricht University, 17 May 2023. Read on Maastricht University website

Innovative drug monitoring of factor VIII and emicizumab in haemophilia A Donners, A. Supervisory team: Prof. dr. A.C.G. Egberts (Utrecht University), prof. dr. R.E.G. Schutgens (UMC Utrecht), dr. C.M.A. Rademaker (UMC Utrecht), dr. K. Fischer (UMC Utrecht) Utrecht University, 1 Jun 2023. Read on Utrecht University Repository

Treatment optimization in patients with non-small cell lung cancer van Veelen, A.J. Supervisory team: Prof. dr. V. Tjan-Heijnen (Maastricht University), dr. P.C. Souverein (Utrecht University), dr. S. Croes (Maastricht University), dr. R. van Geel (Maastricht University). Maastricht University, 1 Jun 2023. Read on Maastricht University website

Supporting successful clozapine treatment Beex-Oosterhuis, M.M. Supervisory team: Prof. dr. R.J. van Marum (free University Amsterdam), dr. E.R. Heerdink (Utrecht University). Free University Amsterdam, 9 Jun 2023. Read on Free University Amsterdam website

Clinical decision support-assisted pharmacotherapy optimisation for older hospitalised patients Huibers, C.J.A. Supervisory team: Prof. dr. A.C.G. Egberts (Utrecht University), prof. dr. R.J. van Marum (Free University Amsterdam), dr. W. Knol (UMC Utrecht), dr. I. Wilting (Utrecht University). Utrecht University, 15 Jun 2023. Read on Utrecht University Repository

Pharmacy staff-patient interactions in challenging situations: Understanding the roots and ways to flourish patient-centered communication Schackmann, L. Supervisory: Prof dr. ir. C.E.M.J. van Dijk (Groningen University), dr. E.S. Koster (Utrecht University), dr. M. Vervloet (NIVEL). University of Groningen, 4 Jul 2023. Read on University of Groningen website

Contextualized clinical decision support to detect and prevent adverse drug events Wasylewicz, A.T.M. Supervisory team: Prof. dr. H.H.M. Korsten (Technical University Eindhoven), prof. dr. A.C.G. Egberts (Utrecht University), dr. R.J.E. Grouls (Catharina hospital Eindhoven). Technical University Eindhoven, 7 Jul 2023. Read on Technical University Eindhoven website

Strategies to optimise the treatment of community-acquired pneumonia Wittermans, E. Supervisory team: Prof. dr. Bos, prof. dr. W.J.W., Grutters, J.C., dr. van de Garde, E.M.W. University Leiden, 28 Sept 2023. Read on Leiden University website

New medicines in primary care: perspectives and practices of healthcare professionals Dankers, M. Supervisory team: Prof. dr. ir. L. van Dijk, prof. dr. A.K. Mantel-Teeuwisse, dr. H.J.M.G. Nelissen-Vrancken University of Groningen, 14 Nov 2023 Read on University of Groningen website

Drug exposure assessment in pharmacoepidemiological database studies: Reporting and impact of exposure misclassification Hempenius, M. Supervisory team: prof. dr. O.H. Klungel, prof. dr. A. de Boer, dr. H. Gardarsdottir. Utrecht University (Faculty of Science), 7 Mar 2022 Read on Utrecht University Repository

The pharmacokinetics of targeted anticancer drugs and food toxins: Roles of ABC efflux and OATP uptake transporters Wang, J. Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 21 Mar 2022 Read on Utrecht University Repository  

Clinical development of anticancer treatment with oral taxanes in combination with ritonavir Vermunt, M.A.C. Supervisory team: prof. dr. J.H. Beijnen, dr. A.M. Bergman, dr. S. Marchetti. Utrecht University (Faculty of Science), 11 May 2022

Real-world data in cancer treatment: Bridging the gap between trials and clinical practice Ismail, R.K. Supervisory team: prof. dr. A. de Boer, prof. dr. M.W.J.M. Wouters, dr. D.L. Hilarius, dr. M. van Dartel. Utrecht University (Faculty of Science), 18 May 2022 Read on Utrecht University Repository

The role of the community pharmacist in fall prevention: The ups and downs of implementation Gemmeke. M. Supervisory team: prof. dr. M.L. Bouvy, prof. dr. K. Taxis, dr. E.S. Koster. Utrecht University (Faculty of Science), 25 May 2022 Read on Utrecht University Repository

Unraveling the functions of detoxification enzymes and drug transporters Wang, Y. Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 12 Jul 2022 Read on Utrecht University Repository

Quality of biopharmaceuticals: Comparability exercise and post-approval surveillance Alsamil, A.M. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. H. Gardarsdottir, dr. T.J. Giezen. Utrecht University (Faculty of Science), 3 Nov 2022 Read on Utrecht University Repository

The role of the community pharmacist in minor ailments, focus on uncomplicated urinary tract infection in women: Focus on uncomplicated urinary tract infection in women Lelie- van der Zande, A.C.A.M. Supervisory team: prof. dr. M.L. Bouvy, dr. E.S. Koster, dr. M. Teichert. Utrecht University (Faculty of Science), 23 Nov 2022 Read on Utrecht University Repository

Medication optimisation in hospitalised older people with polypharmacy and multimorbidity Sallevelt, B.T.G.M. Supervisory team: prof. Egberts, A.C.G., dr. van Puijenbroek, A.A.F.L, dr. Wilting, J. & dr. Knol, E.F. UMCU, 20 Oct 2022 Read on Utrecht University Repository

Real-world treatment outcomes in metastatic lung cancer: from efficacy-effectiveness gap evaluation to informed clinical decision-making Van der Welle, C.M. Supervisory team: dr. E.M.W. van de Garde, dr. F.M.N.H. Schramel, prof. dr. H.J.M. Groen, prof. dr. O.H. Klungel. Utrecht University (Faculty of Science), 29 Mar 2021. Read on Utrecht University Repository

Development, market authorization and market access of gene and cell-based therapies Ten Ham, R.M.T. Supervisory team: dr. J. Hoekman, dr. G.W.J. Frederix, prof. dr. H.G.M. Leufkens, prof. dr. O.H. Klungel. Utrecht University (Faculty of Science), 4 Jun 2021. Read on Utrecht University Repository

Post-marketing safety learning for biologicals: regulatory and clinical insights Minnema, L.A. Supervisory team: dr. H. Gardarsdottir, dr. T.J. Giezen, prof. dr. A.C.G. Egberts, prof. dr. H.G.M. Leufkens. Utrecht University (Faculty of Science), 28 Jun 2021. Read on Utrecht University Repository

Advanced pharmacoepidemiologic approaches to study the utilization, safety, and effectiveness of NOAC treatment in patients with atrial fibrillation Komen, J.J. Supervisory team: dr. T. Forslund, prof. dr. B. Wettermark, prof. dr. A.K. Mantel-Teeuwisse, prof. dr. O.H. Klungel. Utrecht University (Faculty of Science), 30 Jun 2021. Read on Utrecht University Repository

Clinical pharmacology of miltefosine Palić, S. Supervisory team: dr. T.P.C. Dorlo, prof. dr. J.H. Beijnen. Utrecht University (Faculty of Science), 10 Sep 2021. Read on Utrecht University Repository

The changing face of community pharmacy practice: increasing time for our priorities Van de Pol, J.M. Supervisory team: dr. E.S. Koster, prof. dr. M.L. Bouvy. Utrecht University (Faculty of Science), 27 Sep 2021. Read on Utrecht University Repository

Psychotropic medication use in the armed forces: prescription patterns and treatment after trauma Janssen-Knotnerus, D.A. Supervisory team: dr. E.R. Heerdink, prof. dr. H.G.J.M. Vermetten, prof. dr. A.C.G. Egberts. Utrecht University (Faculty of Medicine), 28 Sep 2021. Read on Utrecht University Repository

Access to sexual and reproductive health medicines and supplies in Sub-Saharan Africa Kibira, D. Supervisory team: dr. H.A. van den Ham, T. Reed, prof. dr. H.G.M. Leufkens, prof. dr. A.K. Mantel-Teeuwisse. Utrecht University (Faculty of Science), 10 Nov 2021. Read on Utrecht University Repository

Cyclin-dependent kinase inhibitors in cancer: bioanalysis and pharmacokinetics Martínez Chávez, D.A. Supervisory team: dr. A.H. Schinkel, prof. dr. J.H. Beijnen. Utrecht University (Faculty of Science), 10 Nov 2021. Read on Utrecht University Repository

Moral dilemmas of community pharmacists: reflection on professional values Kruijtbosch, M. Supervisory team: dr. A. Floor-Schreudering, prof. dr. E van Leeuwen, prof. dr. M.L. Bouvy. Utrecht University (Faculty of Science), 17 Nov 2021. Read on Utrecht University Repository

Evidence generation on benefits and risks of medicines and its impact Bloem, L.T. Supervisory team: Prof. dr. A.K. Mantel-Teeuwisse, prof. dr. O.H. Klungel, dr. J. Hoekman, dr. M.E. van der Elst. Utrecht University (Faculty of Science), 24 Nov 2021. Read on Utrecht University Repository

Functions and interplay of drug transporters and CYP3A enzymes Li, W. Supervisory team: Prof. dr. J.H. Beijnen, dr. A.H. S, dr. R.W. Sparidans. Utrecht University (Faculty of Science) 15 Dec 2021. Read on Utrecht University Repository

Development and validation of diagnostic and pharmacodynamic cancer biomarker methods and their (pre)clinical application Pluim D. Supervisory team: Prof. dr. J.H. Beijnen, dr. D. Brandsma. Utrecht University (Faculty of Science) 20 Dec 2021. Read on Utrecht University Repository

Observational studies on skin cancer risk: focus on genetics, alcohol and phototoxic medicines Siiskonen, S.J. Supervisory team: prof. dr. M. Airaksinen (University of Helsinki) & dr. H. Gardarsdottir (Utrecht University) University of Helsinki (Faculty of Pharmacy ), 4 Jun 2021. Read on University of Helsinki Open Repository

Methodological approaches to manage challenges to the implementation of HTA and economic evaluations in Low and Middle-Income Countries (LMICs)  Padmasawitri, A. Supervisory team: prof. dr. O.H. Klungel, dr. A.M. Hövels, dr. G.W.J. Frederix. Utrecht University (Faculty of Science), 6 Jan 2020.

Clinical pharmacology of anti-hormonal drugs and oncology - bioanalysis - therapeutic drug monitoring - gemcitabine in oncology - microdosing Van Nuland, M. Supervisory team: prof. dr. J.H. Beijnen, dr. H. Rosing, dr. A.M. Bergman. Utrecht University (Faculty of Science), 22 Jan 2020. Read on Utrecht University Repository

Regulating gene and cell-based therapies as medicinal products  Coppens, D.G.M. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. M.L. De Bruin, dr. J. Hoekman, dr. H. Gardarsdottir. Utrecht University (Faculty of Science), 27 Jan 2020. Read on Utrecht University Repository

Intracellular quantification and pharmacokinetics of pyrimidine analogues used in oncology Derissen, E.J.B. Supervisory team: prof. dr. J.H. Beijnen, dr. H. Rosing. Utrecht University (Faculty of Science), 29 Jan 2020. Read on Utrecht University Repository

Translational research of combined anticancer therapies targeting the MAPK pathway Huijberts, S.C.F.A. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. R. Bernards, dr. N. Steeghs, dr. F. Opdam. Utrecht University (Faculty of Science), 14 Oct 2020. Read on Utrecht University Repository

Health technology assessment throughout the drug lifecycle Vreman, R.A. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.K. Mantel-Teeuwisse, dr. ir. W. Goettsch. Utrecht University (Faculty of Science), 13 Nov 2020. Read on Utrecht University Repository

A quest through diagnostics and predictive tools and the exploration of new treatment strategies in clinical trials to improve cancer therapy Heinhuis, K.M. Supervisory team: prof. dr. J.H. Beijnen, dr. N. Steeghs, dr. W.J. van Houdt. Utrecht University (Faculty of Science), 30 Nov 2020. Read on Utrecht University Repository

Overview since 1989

Evolving national pharmacovigilance systems in Africa Ampadu, H.H. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.N.O. Dodoo, dr. J. Hoekman, dr. H. Gardarsdottir. Utrecht University (Faculty of Science), 9 Jan 2019. Read on Utrecht University Repository

Mounting an attack on the glioblastoma triad: proliferation, invasion and resistance De Gooijer, M.C. Supervisory team: prof. dr. J.H. Beijnen, dr. O. van Tellingen. Utrecht University (Faculty of Science), 23 Jan 2019. Read on Utrecht University Repository

Adolescents perspectives on chronic medication use: opportunities for mHealth Kosse, R.C. Supervisory team: prof. dr. M.L. Bouvy, dr. E.S. Koster, dr. T.W. de Vries. Utrecht University (Faculty of Science), 20 Feb 2019. Read on Utrecht University Repository

Clinical medication review: one step beyond: computer rules or personal goals?  Verdoorn, M.A. Supervisory team: prof. dr. M.L. Bouvy, prof. dr. J. Gussekloo, dr. H.F. Kwint. Utrecht University (Faculty of Science), 13 Mar 2019. Read on Utrecht University Repository

Pharmacometrics for treatment optimization and drug development in oncology De Vries Schultink, A.H.M. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. A.D.R. Huitema, dr. T.P.C. Dorlo. Utrecht University (Faculty of Science), 29 May 2019. Read on Utrecht University Repository

Non-inferiority studies: a methodological and regulatory perspective Althunian, T.A.I. Supervisory team: prof. dr. A. de Boer, prof. dr. O.H. Klungel, prof. dr. R.H.H. Groenwold. Utrecht University (Faculty of Science), 24 Jun 2019. Read on Utrecht University Repository

Multidose dispensing for older patients in primary care Mertens, B. Supervisory team: prof. dr. M.L. Bouvy, prof. dr. R.J. van Marum, dr. H.F. Kwint. Utrecht University (Faculty of Science), 3 Jul 2019. Read on Utrecht University Repository

Clinical pharmacology of anticancer agents with focus on neuro-oncology and biomarker assessment Van Bussel, M.T.J. Supervisory team: prof. dr. J.H. Beijnen, dr. D. Brandsma. Utrecht University (Faculty of Science), 11 Sept 2019. Read on Utrecht University Repository

Appropriate access to opioid medicines: a legal & policy perspective Vranken, M.J.M. Supervisory team: prof. dr. A.K. Mantel-Teeuwisse, prof. dr. H.G.M. Leufkens, dr. mr. M.D.B. Schutjens. Utrecht University (Faculty of Science), 11 Sept 2019.

Personalized oral anticoagulant treatment: dosing algorithm, drug interactions and economic aspects Zhang, Y. Supervisory team: prof. dr. A. de Boer, prof. dr. A. H. Maitland-Van Der Zee, dr. P.C. Souverein. Utrecht University (Faculty of Science), 16 Sept 2019. Read on Utrecht University Repository

Early phase clinical studies of novel immunotherapeutics in oncology Ros, W. Supervisory team: prof. dr. J.H. Beijnen. Utrecht University (Faculty of Science), 18 Sept 2019. Read on Utrecht University Repository

The destiny of anti-cancer drugs: the impact of drug transporters and drug-metabolizing enzymes on the pharmacokinetics of anti-cancer therapies Van Hoppe, S.S. Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 25 Sept 2019. Read on Utrecht University Repository

Death recording in the clinical practice research datalink Gallagher, A.M. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. F. de Vries. Utrecht University (Faculty of Science), 21 Oct 2019. Read on Utrecht University Repository

Regulation in the dynamic environment of complex medicines Klein, K. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. M.L. De Bruin, dr. P. Stolk. Utrecht University (Faculty of Science), 23 Oct 2019.

Bioanalysis and biotransformation of tyrosine kinase inhibitors in oncology Rood, J.J.M. Supervisory team: prof. dr. J.H. Beijnen, dr. ir. R.W. Sparidans. Utrecht University (Faculty of Science), 28 Oct 2019.

Approaches to improve the quality and efficiency of clinical pharmacological trials in oncology Roosendaal, J. Supervisory team: prof. dr. J.H. Beijnen, dr. H. Rosing. Utrecht University (Faculty of Science), 30 Oct 2019.

Safety profile of non-steroidal anti-inflammatory drugs in clinical practice Bakhriansyah, M. Supervisory team: prof. dr. A. de Boer, prof. dr. O.H. Klungel. Utrecht University (Faculty of Science), 6 Nov 2019. Read on Utrecht University Repository

Affordability, cost-effectiveness and uncertainty: an integrated approach for decision-making on medicines Geenen, J.W. Supervisory team: prof. dr. O.H. Klungel, dr. A.M. Hövels, dr. C. Boersma. Utrecht University (Faculty of Science), 11 Dec 2019. Read on Utrecht University Repository

Non-dispensing clinical pharmacists in general practice: training, implementation and clinical effects Hazen, A.C.M. Supervisory team: prof. dr. M.L. Bouvy, prof. dr. N.J. de Wit, dr. A.A. de Bont, dr. D.L.M. Zwart. Utrecht University (Faculty of Science), 29 Jan 2018. Read on Utrecht University Repository

Precision medicine steps towards improving treatment with vitamin K antagonists and ACE-inhibitors Baranova, E.V. Supervisory team: prof. dr. A. de Boer, prof. dr. F.W. Asselbergs, prof. dr. A.H. Maitland-van Der Zee. Utrecht University (Faculty of Science), 12 Mar 2018. Read on Utrecht University Repository

Antipsychotics, delirium and glucose in older patients Van Keulen, K. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. W. Knol. Utrecht University (Faculty of Science), 10 Apr 2018. Read on Utrecht University Repository

Real-world evidence for health technology assessment of pharmaceuticals: opportunities and challenges Makady, A.A.M.A. Supervisory team: prof. dr. A. de Boer, prof. dr. J.L. Hillege, prof. dr. O.H. Klungel, dr. W.G. Goettsch. Utrecht University (Faculty of Science), 9 May 2018. Read on Utrecht University Repository

Monitoring patients using psychotropic drugs Nederlof, M. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 11 Jun 2018. Read on Utrecht University Repository

Pharmaceutics of oral anticancer agents and stimulants Herbrink, M. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. B. Nuijen. Utrecht University (Faculty of Science), 27 Jun 2018. Read on Utrecht University Repository

The use and safety of antiretroviral medicines - lessons from Ghana Tetteh, R.A. Supervisory team: prof. dr. A.K. Mantel-Teeuwisse, prof. dr. A.N.O. Dodoo. Utrecht University (Faculty of Science), 11 Jul 2018. Read on Utrecht University Repository

Safety of antihypertensive drugs in clinical practice Alharbi, F.F.M. Supervisory team: prof. dr. A. de Boer, prof. dr. O.H. Klungel. Utrecht University (Faculty of Science), 29 Aug 2018.

The added value of linked data in pharmacoepidemiology: solving the jigsaw puzzle Williams, R.A. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. T.P. van Staa, dr. F. de Vries. Utrecht University (Faculty of Science), 17 Sept 2018. Read on Utrecht University Repository

Human mass balance and metabolite profiling studies of the new anticancer agents plitidepsin, lurbinectedin and niraparib Van Andel, L. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. H. Rosing. Utrecht University (Faculty of Science), 19 Sept 2018. Read on Utrecht University Repository

Individualized dosing of fluoropyrimidines by genotyping and phenotyping of dihydropyrimidine dehydrogenase Henricks, L.M. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. H.J. Guchelaar, prof. dr. J.H.M. Schellens, dr. A. Cats. Utrecht University (Faculty of Science), 24 Sept 2018. Read on Utrecht University Repository

Patient perspectives in pharmaceutical policy: information and influence in the diffusion of new medicines Meneses Leonardo Alves, T.I. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.K. Mantel-Teeuwisse, dr. B.J. Mintzes. Utrecht University (Faculty of Science), 15 Oct 2018. Read on Utrecht University Repository

Precision anticoagulation with vitamin K antagonists in children Maagdenberg, H. Supervisory team: prof. dr. A. de Boer , prof. dr. A.H. Maitland-van der Zee , dr. M.B. Bierings. Utrecht University (Faculty of Science), 10 Dec 2018. Read on Utrecht University Repository

Pharmaceutical policies and access to medicines: a hospital-pharmacy perspective from Ghana Ankrah, D. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. I.A. Agyepong, prof. dr. A.K. Mantel-Teeuwisse. Utrecht University (Faculty of Science), 11 Jan 2017. Read on Utrecht University Repository

Priority medicines for children: exploring age-appropriate medicines and antibiotic use in children Ivanovska, V. Supervisory team: prof. dr. Leufkens, prof. dr. A.K. Mantel-Teeuwisse, dr. ir. C.E.M.J. van Dijk. Utrecht University (Faculty of Science), 8 Mar 2017. Read on Utrecht University Repository

Antiplatelet drugs for secondary prevention of cardiovascular diseases: drug utilization, effectiveness, and safety Noorsyahdy, A.Y. Supervisory team: prof. dr. A. de Boer, prof. dr. O.H. Klungel, dr. V.H.M. Deneer. Utrecht University (Faculty of Science), 13 Mar 2017. Read on Utrecht University Repository

Solid dispersions in oncology: a solution to solubility-limited oral drug absorption Sawicki, E. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. B. Nuijen. Utrecht University (Faculty of Science), 29 Mar 2017. Read on Utrecht University Repository

Towards better fall prevention: examining the interplay between factor that influence gait in older patients De Groot, M.H. Supervisory team: prof. dr. J.H. Beijnen, dr. C.J.C. Lamoth. Utrecht University (Faculty of Science), 10 May 2017.

Clinical pharmacology and bioanalysis of antileishmanial drugs: towards improved treatment strategies for leishmaniasis Kip, A.E.  Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. T.P.C. Dorlo. Utrecht University (Faculty of Science), 21 Jun 2017. Read on Utrecht University Repository

Pediatric asthma and allergy: an epidemiological approach Arabkhazaeli, A. Supervisory team: prof. dr. J.A.M. Raaijmakers, prof. dr. C.K. van der Ent, prof. dr. A.H. Maitland-van der Zee, dr. S.J.H. Vijverberg. Utrecht University (Faculty of Science), 26 Jun 2017. Read on Utrecht University Repository

Globally applicable facilitated regulatory pathways to improve equitable access to medicines Liberti, L.E.L. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.M. Breckenridge, dr. P. Stolk, dr. N.M. Auslane. Utrecht University (Faculty of Science), 13 Jul 2017. Read on Utrecht University Repository

Unravelling the link between diabetes, insulin treatment and breast cancer Bronsveld, H.K. Supervisory team: prof. dr. A. de Boer, prof. dr. M.L. De Bruin, prof. dr. M.K. Schmidt. Utrecht University (Faculty of Science), 24 Aug 2017. Read on Utrecht University Repository

Optimizing the safety of multidrug-resistant tuberculosis therapy in Namibia Sagwa, E.L. Supervisory team: prof. dr. Leufkens, prof. dr. A.K. Mantel-Teeuwisse. Utrecht University (Faculty of Science), 24 Aug 2017. Read on Utrecht University Repository

The pursuit of user-friendly medicines: older people in the hot seat Notenboom, K. Supervisory team: prof. dr. M.L. Bouvy, prof. dr. H.G.M. Leufkens . Utrecht University (Faculty of Science), 27 Sept 2017. Read on Utrecht University Repository

The role of motivation in continuing education for pharmacists Schouten-Tjin A Tsoi, S. Supervisory team: prof. dr. A. de Boer, prof. dr. G. Croiset, dr. A.S. Koster, dr. R. Kusurkar. Utrecht University (Faculty of Science), 4 Oct 2017. Read on Utrecht University Repository

Trials and tribulations: studies on the fate, transparency and efficiency of clinical drug trials Van den Bogert, C.A. Supervisory team: prof. dr. H.G.M. Leufkens, dr. P.C. Souverein, dr. S.W.J. Janssen. Utrecht University (Faculty of Science), 4 Oct 2017. Read on Utrecht University Repository

Variation in health technology assessment of new medicines: processes and outcomes Lipska, I.L. Supervisory team: prof. dr. H.G.M. Leufkens, dr. A.M. Hövels, dr. N. M. Auslane. Utrecht University (Faculty of Science), 11 Oct 2017. Read on Utrecht University Repository

Readmission to primary care: the role of community pharmacists post-discharge Ensing, H.T. Supervisory team: prof. dr. M.L. Bouvy, dr. E.S. Koster, dr. A.A. van Dooren. Utrecht University (Faculty of Science), 25 Oct 2017. Read on Utrecht University Repository

Clinical decision support in community pharmacy Heringa, M. Supervisory team: prof. dr. M.L. Bouvy, prof. dr. P.A.G.M. de Smet, dr. A. Floor-Schreudering. Utrecht University (Faculty of Science), 30 Oct 2017. Read on Utrecht University Repository

Clinical pharmacology of kinase inhibitors in oncology Verheijen, R.B. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, prof. dr. A.D.R. Huitema, dr. N. Steeghs. Utrecht University (Faculty of Science), 29 Nov 2017. Read on Utrecht University Repository

Early development of targeted anticancer agents Van Brummelen, E.M.J. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen. Utrecht University (Faculty of Science), 18 Dec 2017. Read on Utrecht University Repository

Clinical pharmacology of novel anticancer agents De Weger, V.A. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. S. Marchetti. Utrecht University (Faculty of Science), 20 Dec 2017. Read on Utrecht University Repository

Assessing long-term and rare adverse effects of medicines Duijnhoven, R.G. Supervisory team: prof. dr. A. de Boer, prof. dr. A.W. Hoes, dr. M.L. De Bruin, dr. S.M.J.M. Straus. Utrecht University (Faculty of Science), 18 Jan 2016. Read on Utrecht University Repository

Understanding differences in findings from pharmacoepidemiological studies: the case of antidepressant and benzodiazepine use and hip fracture Abbing-Karahagopian, V. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. M.L. De Bruin, dr. T.P. van Staa. Utrecht University (Faculty of Science), 19 Jan 2016. Read on Utrecht University Repository

Improving safety and effectiveness of fluoropyrimidine-based chemotherapy Meulendijks, D. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. A Cats. Utrecht University (Faculty of Science), 3 Feb 2016. Read on Utrecht University Repository

Access to essential medicines in low and middle income countries Taghipour Bazargani, Y. Supervisory team: prof. dr. A. de Boer, prof. dr. H.G.M. Leufkens, dr. A.K. Mantel-Teeuwisse. Utrecht University (Faculty of Science), 9 May 2016.

Patients at increased fracture risk: identification and pharmacological treatment Klop, C. Supervisory team: prof. dr. H.G.M. Leufkens , prof. dr. J.W.J. Bijlsma, dr. F. de Vries, dr. P.M.J. Welsing. Utrecht University (Faculty of Science), 23 May 2016. Read on Utrecht University Repository

Benefits and risks for the individual, anticoagulation for patients with atrial fibrillation van den Ham, H.A. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. O.H. Klungel, prof. dr. T.P. van Staa. Utrecht University (Faculty of Science), 25 May 2016. Read on Utrecht University Repository

Harmonising relative effectiveness assessments of medicines in Europe Kleijnen, S. Supervisory team: prof. dr. A. de Boer, prof. dr. H.G.M. Leufkens, dr. W.G. Goettsch. Utrecht University (Faculty of Science), 30 May 2016. Read on Utrecht University Repository

Clinical pharmacology of novel anticancer agents: bioanalysis - clinical pharmacokinetics - mass balance studies Nijenhuis, C.M. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. H. Rosing. Utrecht University (Faculty of Science), 15 Jun 2016.

Adverse drug reactions of angiotensin converting enzyme inhibitors: towards precision medicin Mahmoud Pour, S.H. Supervisory team: prof. dr. A. de Boer, prof. dr. F.W. Asselbergs, dr. A.H. Maitland-van der Zee. Utrecht University (Faculty of Science), 29 Jun 2016. Read on Utrecht University Repository

Adjusted indirect treatment comparisons of bioequivalence studies Gwaza, L. Supervisory team: prof. dr. H.G.M. Leufkens, dr. M. Maliepaard, dr. A. Garcia-Arieta. Utrecht University (Faculty of Science), 8 Jul 2016. Read on Utrecht University Repository

Pharmacokinetic-pharmacodynamic modelling & simulation for anticancer drugs with complex absorption characteristics Yu, H. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, prof. dr. A.D.R. Huitema. Utrecht University (Faculty of Science), 31 Aug 2016.

Etiological studies in complex diseases Peeters, P.J.H.L. Supervisory team: prof. dr. H.G.M. Leufkens, dr. M.L. de Bruin. Utrecht University (Faculty of Science), 26 Sept 2016. Read on Utrecht University Repository

Clinical pharmacology of genotype-directed anticancer therapy: towards rational combination strategies van Geel, R.M.J.M. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen. Utrecht University (Faculty of Science), 5 Oct 2016. Read on Utrecht University Repository

Risk factors and treatment of pediatric chronic diseases: type 1 diabetes, asthma and allergy Ahmadizar, F. Supervisory team: prof. dr. A. de Boer, prof. dr. A.H. Maitland-van der Zee. Utrecht University (Faculty of Science), 23 Oct 2016. Read on Utrecht University Repository

Evaluating pharmaceutical policies using cross-national comparisons and time series analysis Santa Ana Tellez, Y. Supervisory team: prof. dr. H.G.M. Leufkens, dr. A.K. Mantel-Teeuwisse, dr. V.J. Wirtz. Utrecht University (Faculty of Science), 26 Oct 2016. Read on Utrecht University Repository

Methods for improving the safety of fluoropyrimidine anticancer drugs Jacobs, B.A.W. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. B. Nuijen. Utrecht University (Faculty of Science), 30 Nov 2016. Read on Utrecht University Repository

Continuous innovation in the drug life cycle Langedijk, J. Supervisory team: prof. dr. H.G.M. Leufkens, dr. A.K. Mantel, dr. mr. M.D.B. Schutjens. Utrecht University (Faculty of Science), 19 Dec 2016. Read on Utrecht University Repository

Revisiting health system performance assessment in Africa Achoki, T.N. Supervisory team: prof. dr. H.G.M. Leufkens, dr. A.M. Hövels. Utrecht University (Faculty of Science), 21 Dec 2016. Read on Utrecht University Repository

Challenges and opportunities in pharmacogenomics: studies in cardiovascular disease and asthma Leusink, M. Supervisory team: prof. dr. A. de Boer, prof. dr. P.I.W. de Bakker, dr. A.H. Maitland, dr. N.C. Onland-Moret. Utrecht University (Faculty of Science), 7 Jan 2015. Read on Utrecht University Repository

Access to medicines: common problems, common solutions? Stephens, P.N. Supervisory team: prof. dr. H.G.M. Leufkens. Utrecht University (Faculty of Science), 12 Jan 2015. Read on Utrecht University Repository

Pediatric type 1 and 2 diabetes mellitus: epidemiology, comorbidities, and medication utilization Fazelifarsani, S. Supervisory team: prof. dr. A. de Boer, prof. dr. C.A.J. Knibbe, dr. M van der Vorst, dr. A.K. Mantel-Teeuwisse. Utrecht University (Faculty of Science), 19 Jan 2015. Read on Utrecht University Repository

Challenges in the clinical development of orphan drugs Kreeftmeijer-Vegter, A.R. Supervisory team: prof. dr. A. de Boer, dr. P.J. de Vries. Utrecht University (Faculty of Science), 9 Feb 2015. Read on Utrecht University Repository

Novel systemic treatment options for advanced solid tumors with or without central nervous system metastases or malignant glioma Milojkovic Kerklaan, B.M.K. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. D. Brandsma. Utrecht University (Faculty of Science), 25 Mar 2015. Read on Utrecht University Repository

Antidepressant use in pregnancy: knowledge transfer and translation of research findings Einarson, A. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 8 Apr 2015. Read on Utrecht University Repository

Continuity of pharmaceutical care for psychiatric patients Abdullah-Koolmees, H. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. H. Gardarsdottir. Utrecht University (Faculty of Science), 29 Apr 2015. Read on Utrecht University Repository

Trust in the pharmaceutical sector: analysis of drug safety controversies by means of drug life cycles Hernandez, J.F. Supervisory team: prof. dr. A.H.L.M. Pieters, prof. dr. J.A.M. Raaijmakers, dr. A.K. Mantel-Teeuwisse, dr. G.J.M.W. van Thiel. Utrecht University (Faculty of Science), 3 Jun 2015. Read on Utrecht University Repository

Supporting patients: pharmacy based interventions to improve medication adherence Kooij, M.J. Supervisory team: prof. dr. M.L. Bouvy, dr. E.R. Heerdink, dr. ir. C.E.M.J. van Dijk. Utrecht University (Faculty of Science), 9 Sept 2015. Read on Utrecht University Repository

Psychotropic drug use in people with intellectual disability: patterns of use and critical evaluation: patterns of use and critical evaluation Scheifes, A. Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. H. Nijman, dr. E.R. Heerdink, dr. J.J. Stolker. Utrecht University (Faculty of Science), 7 Oct 2015. Read on Utrecht University Repository

Pharmacovigilance of biologicals: dynamics in post-approval safety learning Vermeer, N.S. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. M.L. De Bruin, dr. S.M.J.M. Straus. Utrecht University (Faculty of Science), 14 Oct 2015. Read on Utrecht University Repository

The RT-18: a new instrument to assess adolescent and young adult risk-taking behavior Haan, de L. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 16 Dec 2015. Read on Utrecht University Repository

Pharmaceutical policy analysis – a European perspective on pricing and reimbursement in challenging times Leopold, C. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R. Laing, dr. A.K. Mantel-Teeuwisse, dr. S. Vogler. Utrecht University (Faculty of Science), 8 Jan 2014.

Complications of hip and knee replacement surgery: a pharmaco-epidemiological approach Lalmohamed, A. Supervisory team: prof. dr. A. de Boer, prof. dr. H.G.M. Leufkens, prof. dr. T.P. van Staa, dr. F. de Vries. Utrecht University (Faculty of Science), 27 Jan 2014. Read on Utrecht University Repository

Population-based studies on risk of fracture in patients with neurological disorders Pouwels, S. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A. de Boer, prof. dr. T.P. van Staa, dr. F. de Vries. Utrecht University (Faculty of Science), 27 Jan 2014. Read on Utrecht University Repository

Integrated quantitative pharmacology for treatment optimization in oncology Van Hasselt, J.G. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. A.D.R. Huitema. Utrecht University (Faculty of Science), 29 Jan 2014. Read on Utrecht University Repository

Disease and drug-induced arrhythmias: the example of obstructive pulmonary disease Warnier, M.J. Supervisory team: prof. dr. A. de Boer, prof. dr. A.W. Hoes, dr. M.L. de Bruin, dr. F.H. Rutten. Utrecht University (Faculty of Science), 10 Feb 2014. Read on Utrecht University Repository

Treatment response in childhood asthma. An interplay of genes and inflammatory signals Vijverberg, S.J.H. Supervisory team: prof. dr. J.A.M. Raaijmakers, prof. dr. L. Koenderman, dr. A.H. Maitland-van der Zee. Utrecht University (Faculty of Science), 9 Apr 2014. Read on Utrecht University Repository

Translational pharmacology and bioanalysis of oral taxanes Hendrikx, J.J.M.A. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. H. Rosing, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 16 Apr 2014. Read on Utrecht University Repository

Lithium in older patients: treatment patterns and somatic adverse effects Van Melick, E.J.M. Supervisory team: prof. dr. A.C.G. Egberts, dr. I. Wilting. Utrecht University (Faculty of Science), 17 Apr 2014. Read on Utrecht University Repository

Anti-cancer drug disposition: in vitro and in vivo functions of ABC efflux and OATP uptake transporters Durmus, S. Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 5 Sept 2014. Read on Utrecht University Repository

Childhood obesity: medical, cultural and psychological factors Radhakishun, N.N.E. Supervisory team: Prof. dr. J.H. Beijnen, prof. dr. M.H.H. Kramer, prof. dr. D.P.M. Brandjes. Utrecht University (Faculty of Science), 10 Sept 2014. Read on Utrecht University Repository

Safety, pharmacokinetics and preliminary anti-tumor activity of novel (combinations of) targeted anti-cancer drugs Van Noll, R. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen. Utrecht University (Faculty of Science), 15 Sept 2014.

Bioanalysis and clinical pharmacology of tamoxifen in breast cancer. Jager, N.G.L. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens Utrecht University (Faculty of Science), 17 Sept 2014. Read on Utrecht University Repository

Improving propensity score methods in pharmacoepidemiology Ali, M.S. Supervisory team: prof. dr. A. de Boer, prof. dr. A.W. Hoes, prof. dr. O.H. Klungel, dr. R.H.H. Groenwold. Utrecht University (Faculty of Science), 1 Oct 2014. Read on Utrecht University Repository

Child friendly medicines. Availability, pharmaceutical design, usability and patient outcomes Riet-Nales, D.A. Supervisory team: prof. dr. A.F.A.M. Schobben, prof. dr. A.C.G. Egberts, dr. C.M.A. Rademaker. Utrecht University (Faculty of Science), 26 Nov 2014. Read on Utrecht University Repository

Performance of statistical methods to control for unmeasured confounding in pharmacoepidemiology. Focus on instrumental variable analysis Uddin, M.J. Supervisory team: prof. dr. A. de Boer, prof. dr. K.C.B. Roes, dr. R.H.H. Groenwold, dr. O.H. Klungel. Utrecht University (Faculty of Science), 15 Dec 2014. Read on Utrecht University Repository

Understanding access to medicines in low- and middle-income countries through the use of price and availability indicators Cameron, A.M. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R. Laing, dr. A.K. Mantel-Teeuwisse. Utrecht University (Faculty of Science), 10 Jan 2013. Read on Utrecht University Repository

Bioanalysis and clinical pharmacology of tyrosine kinase inhibitors Lankheet, A.G. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. A.D.R. Huitema. Utrecht University (Faculty of Science), 13 Feb 2013. Read on Utrecht University Repository

Targeted therapies for malignant gliomas: novel agents, same barrier Lin, F. Supervisory team: prof. dr. J.H. Beijnen, dr. O. van Tellingen. Utrecht University (Faculty of Science), 1 Mar 2013. Read on Utrecht University Repository

Development of combination therapy with anti-cancer drugs Leijen, S. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen. Utrecht University (Faculty of Science), 15 Mar 2013. Read on Utrecht University Repository

Cross-country variation in medicines use: a pharmaceutical system perspective Hoebert, J.M. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R. Laing, dr. A.K. Mantel-Teeuwisse, dr. ir. C.E.M.J. van Dijk. Utrecht University (Faculty of Science), 8 Apr 2013. Read on Utrecht University Repository

Towards optimal dosing of coumarin derivatives: the role of pharmacogenetics Van Schie, R.M.F. Supervisory team: prof. dr. A. de Boer, dr. A.H. Maitland-van der Zee,  dr. F.J.M. van der Meer. Utrecht University (Faculty of Science), 10 Apr 2013. Read on Utrecht University Repository

Bioanalysis and clinical pharmacology of antiviral drugs - focus on HIV and influenza Kromdijk, W. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. A.D.R. Huitema, dr. J.W. Mulder. Utrecht University (Faculty of Science), 24 Apr 2013.

Clinical pharmacokinetic interactions between herbal supplements and anticancer drugs Goey, A.K.L. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. ir. I. Meijerman. Utrecht University (Faculty of Science), 15 May 2013. Read on Utrecht University Repository

Improving appropriate medication use for older people in primary care Kwint, H.F. Supervisory team: prof. dr. M.L. Bouvy, prof. dr. J. Gussekloo, dr. A. Faber. Utrecht University (Faculty of Science), 29 May 2013. Read on Utrecht University Repository

Disease specific methods for economic evaluations of breast cancer therapies Frederix, G.W.J. Supervisory team: prof. dr. J.H.M. Schellens, dr. J.L. Severens, dr. A.M. Hövels. Utrecht University (Faculty of Science), 12 Jun 2013. Read on Utrecht University Repository

Marketing authorisation of new medicines in the EU: towards evidence-based improvement Putzeist, M. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.W. Hoes, dr. A.K. Mantel-Teeuwisse, dr. C.C. Gispen-de Wied. Utrecht University (Faculty of Science), 19 Jun 2013. Read on Utrecht University Repository

Medicine on demand, medication patterns and glycemic control in patients with type 2 diabetes Lamberts, E.J.F. Supervisory team: prof. dr. M.L. Bouvy, prof. dr. M.G.A.A.M. Nijpels, dr. P.C. Souverein, dr. J.G. Hugtenburg. Utrecht University (Faculty of Science), 19 Jun 2013. Read on Utrecht University Repository

Exploring the regulatory decision-making process for medicines Tafuri, G. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R. Laing. Utrecht University (Faculty of Science), 1 Jul 2013. Read on Utrecht University Repository

Impact of apical ABC transporters on pharmacokinetics of targeted anticancer drugs Tang, S.C. Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 3 Jul 2013. Read on Utrecht University Repository

Drug trafficking in mice: in vivo functions of OATP uptake and ABC efflux transporters Iusuf, D. Supervisory team: prof. dr. J.H. Beijnen, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 11 Sept 2013. Read on Utrecht University Repository

Clinical pharmacology of novel anticancer drug formulations Stuurman, F.E. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen. Utrecht University (Faculty of Science), 18 Sept 2013. Read on Utrecht University Repository

Development of an oral dosage form of capecitabine with modified release characteristics Meulenaar, J. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. B. Nuijen. Utrecht University (Faculty of Science), 25 Sept 2013. Read on Utrecht University Repository

Production and pharmaceutical formulation of plasmid DNA vaccines Van der Heijden, I. Supervisory team: prof. dr. J.H. Beijnen, dr. B. Nuijen. Utrecht University (Faculty of Science), 16 Oct 2013. Read on Utrecht University Repository

Development and clinical application of oral dosage forms of taxanes Moes, J.J. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. B. Nuijen. Utrecht University (Faculty of Science), 30 Oct 2013. Read on Utrecht University Repository

Personalised treatment with oral anticoagulant drugs: clinical and economic issues Verhoef, T.I. Supervisory team: prof. dr. A. de Boer, dr. A.H. Maitland-van der Zee, dr. W.K. Redekop. Utrecht University (Faculty of Science), 20 Nov 2013. Read on Utrecht University Repository

Effects of Complementary and Alternative Medicines (CAM) on the metabolism and transport of anticancer drugs Mooiman, K.D. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. ir. I. Meijerman. Utrecht University (Faculty of Science), 18 Dec 2013. Read on Utrecht University Repository

Measuring and prediction medication adherence using dispensing data and patient beliefs Geers, H.C.J. Supervisory team: prof. dr. M.L. Bouvy, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 1 Feb 2012. Read on Utrecht University Repository

Genetic determinants for metabolic abnormalities Risselada, A.J. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. H. Mulder. Utrecht University (Faculty of Science), 8 Feb 2012. Read on Utrecht University Repository

Transitional pharmaceutical care for patients discharged from the hospital Karapinar, F. Supervisory team: prof. dr. A.C.G. Egberts, dr. P.M.L.A. van den Bemt, dr. S.D. Borgsteede. Utrecht University (Faculty of Science), 25 Apr 2012. Read on Utrecht University Repository

Bioanalysis and metabolite identification of anticancer drugs in mass balance studies Dubbelman, A.C. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. H. Rosing. Utrecht University (Faculty of Science), 23 May 2012. Read on Utrecht University Repository

Pandemic influenza A (H1N1) and other respiratory pathogens: clinical insights - from epidemiology to treatment Smit, P.M. Supervisory team: prof. dr. J.H. Beijnen, dr. J.W. Mulder, dr. D.P.M. Brandjes. Utrecht University (Faculty of Science), 11 Jun 2012.

Antineoplastic drugs in veterinary oncology: excretion in dogs, contamination of the environment and exposure assessment of people at risk Janssens, T. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. E.E.M. Brouwers. Utrecht University (Faculty of Science), 5 Oct 2012. Read on Utrecht University Repository

Non-inferiority trials: methodological and regulatory challenges Wangge, G. Supervisory team: prof. dr. A. de Boer, prof. dr. A.W. Hoes, dr. M.J. Knol, dr. O.H. Klungel. Utrecht University (Faculty of Science), 5 Nov 2012. Read on Utrecht University Repository

Genetic determinants of antipsychotic drug response Gregoor, J.G. Supervisory team: prof. dr. A.C.G. Egberts, dr. J. van der Weide, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 14 Nov 2012. Read on Utrecht University Repository

Laboratory markers in personalized drug therapy Geerts, A.F.J. Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. W.W. van Solinge, prof. dr. P.G.A.M. de Smet, dr. G.H.P. de Koning. Utrecht University (Faculty of Science), 28 Nov 2012. Read on Utrecht University Repository

A combinatorial approach to electronic healthcare records in pharmacoepidemiology Bazelier, M.T. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. T.P. van Staa, dr. F. de Vries. Utrecht University (Faculty of Science), 19 Dec 2012. Read on Utrecht University Repository

Treatment optimization of fluoropyrimidines as single agent and in combination therapy Deenen, M.J. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. A. Cats. Utrecht University (Faculty of Science), 26 Jan 2011. Read on Utrecht University Repository

Intravenous-to-oral switch in anticancer chemotherapy: focus on taxanes and gemcitabine Koolen, S.L.W. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen, dr. A.D.R. Huitema. Utrecht University (Faculty of Science), 16 Feb 2011. Read on Utrecht University Repository

Influence of genetic variants and drug interactions on the response to antiplatelet drugs Harmsze, A.M. Supervisory team: prof. dr. A. de Boer, dr. V.H.M. Deneer, dr. O.H. Klungel. Utrecht University (Faculty of Science), 9 Mar 2011. Read on Utrecht University Repository

Evaluation and management of side effects of breast cancer treatment Boekhout, A.H. Supervisory team: prof. dr. J.H.M. Schellens, prof. dr. J.H. Beijnen. Utrecht University (Faculty of Science), 16 Mar 2011. Read on Utrecht University Repository

Risk management of biologicals: a regulatory and clinical perspective Giezen, T.J. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. A.K. Mantel, dr. S.M.J.M. Straus. Utrecht University (Faculty of Science), 21 Mar 2011. Read on Utrecht University Repository

Pharmacogenetics of antihypertensive drugs and the risk of diabetes Bozkurt, O. Supervisory team: prof. dr. A. de Boer, prof. dr. D.E. Grobbee, dr. O.H. Klungel. Utrecht University (Faculty of Science), 30 Mar 2011. Read on Utrecht University Repository

The context of medicines’ use in benefit-risk evaluation Willemen, M.J.C. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. A.K. Mantel-Teeuwisse, dr. S.M.J.M. Straus. Utrecht University (Faculty of Science), 20 Apr 2011. Read on Utrecht University Repository

Melatonin in sleepless children: everything has a rhythm? Van Geijlswijk, I.M. Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. H. Vaarkamp, dr. M.G. Smits. Utrecht University (Faculty of Science), 27 Apr 2011. Read on Utrecht University Repository

Bioanalysis and metabolism of tamoxifen and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine - applications in pharmacology Teunissen, S.F. Supervisory team: prof. dr. J.H. Beijnen, prof. dr. J.H.M. Schellens, dr. H. Rosing, dr. A.H. Schinkel. Utrecht University (Faculty of Science), 25 May 2011.

Balancing the benefits and risks of antipsychotic use in elderly patients Kleijer, B. Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. M.W. Ribbe, dr. R.J. van Marum, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 19 Oct 2011. Read on Utrecht University Repository

Antipsychotic induced parkinsonism in the elderly: assessment, causes and consequences Knol, W. Supervisory team: prof. dr. A.F.A.M. Schobben, prof. dr. A.C.G. Egberts, dr. R.J. van Marum, dr. P.A.F. Jansen. Utrecht University (Faculty of Science), 21 Oct 2011. Read on Utrecht University Repository

Medication changes in patients transitioning between health care settings Stuffken, R. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 23 Nov 2011. Read on Utrecht University Repository

Towards better treatment outcomes in childhood asthma Koster, E.S. Supervisory team: prof. dr. J.A.M. Raaijmakers, dr. A.H. Maitland-van der Zee. Utrecht University (Faculty of Science), 26 Oct 2011. Read on Utrecht University Repository

Innovative approaches for pharmaceutical policy research in developing countries: the view through a market lens Waning, B.J. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R. Laing. Utrecht University (Faculty of Science), 19 Dec 2011. Read on Utrecht University Repository

Comparative information on new medicines: availability, quality and usage Van Luijn, J.C.F. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. F.W.J. Gribnau. Utrecht University (Faculty of Science), 13 Jan 2010. Read on Utrecht University Repository

From research on rare diseases to new orphan drug development Heemstra, H.E. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. H.A. Büller, dr. S van Weely, dr. R.L.A. Vrueh. Utrecht University (Faculty of Science), 3 Feb 2010. Read on Utrecht University

Markers for disease severity: pharmacoepidemiological studies on obstructive lung disease Velthove, K.J. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. W.W. van Solinge, dr. R.C. Schweizer, dr. P.C. Souverein. Utrecht University (Faculty of Science), 19 Feb 2010. Read on Utrecht University Repository

Pharmacotherapy and aggressive behaviour in psychiatric patients Goedhard, L.E. Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. H.L.I. Nijman, dr. E.R. Heerdink, dr. J.J. Stolker. Utrecht University (Faculty of Science), 16 Jun 2010. Read on Utrecht University Repository

Mechanism-based drug exposure classification in pharmacoepidemiological studies Verdel, B.M. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts, dr. P.C. Souverein. Utrecht University (Faculty of Science), 29 Sept 2010. Read on Utrecht University Repository

Methodological approaches to the pharmacogenomics of statins Peters, B.J.M. Supervisory team: prof. dr. A. de Boer, dr. A.H. Maitland-van der Zee, dr. O.H. Klungel. Utrecht University (Faculty of Science), 12 Dec 2010. Read on Utrecht University Repository

Laboratory markers in drug safety research: studies on drug-induced thrombocytopenia Ten Berg, M.J. Supervisory team: prof. dr. W.W. van Solinge, prof. dr. A.C.G. Egberts, dr. P.M.L.A. van den Bemt, dr. A. Huisman. Utrecht University (Faculty of Science), 17 Jun 2009. Read on Utrecht University Repository

Pharmacogenetics of antihypertensive drug treatment - design and conduct of an observational study Van Wieren-de Wijer, B.M.A. Supervisory team: prof. dr. A. de Boer, prof. dr. B.H.Ch. Stricker, dr. O.H. Klungel, dr. A.H. Maitland-van der Zee. Utrecht University (Faculty of Science), 7 Oct 2009.

Drug treatment episodes in pharmacoepidemiology - antidepressant use as a model Gardarsdottir, H. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 21 Oct 2009. Read on Utrecht University Repository

Influence of antidepressants on glucose homeostasis: effects and mechanisms Derijks, H.J. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. G.H.P. de Koning, dr. R. Janknegt. Utrecht University (Faculty of Science), 11 Nov 2009.

Costs and effects of statin therapy in daily practice Gumbs, P.D. Supervisory team: prof. dr. A. de Boer, dr. O.H. Klungel, dr. W.M.M. Verschuren. Utrecht University (Faculty of Science), 19 Mar 2008.

Adherence to inhaled corticosteroids and patient perception: towards a better understanding and individualised care Menckeberg, T.T. Supervisory team: prof. dr. J.A.M. Raaijmakers, prof. dr. J.W.J. Lammers, dr. M.L. Bouvy, dr. M. Bracke. Utrecht University (Faculty of Science), 20 Mar 2008. Read on Utrecht University Repository

Patterns and clinical outcomes of lithium treatment Wilting, I. Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. W.A. Nolen, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 9 Apr 2008. Read on Utrecht University Repository

From new molecules to leads for innovation: studies on the post-innovation learning cycle for pharmaceuticals Stolk, P. Supervisory team: prof. dr. H.G.M. Leufkens, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 15 Sept 2008. Read on Utrecht University Repository

Children and asthma medication: when is that inhaler just a breath away? Zuidgeest, M.G.P. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. ir. B. Brunekreef, dr. M. Bracke, dr. H.A. Smit. Utrecht University (Faculty of Science), 8 Oct 2008. Read on Utrecht University Repository

Initiation, execution and discontinuation of antidepressant therapy: considerations and decisions of patients Van Geffen, E.C.G. Supervisory team: prof. dr. A.C.G. Egberts, dr. E.R. Heerdink, dr. R.P. Van Hulten. Utrecht University (Faculty of Science), 29 Oct 2008. Read on Utrecht University Repository

Systemic inflammatory responses in asthma Ten Hove, W. Supervisory team: prof. dr. J.A.M. Raaijmakers, prof. dr. L. Koenderman, dr. M. Bracke. Utrecht University (Faculty of Science), 31 Jan 2007. Read on Utrecht University Repository

Unintended effects of inhaled corticosteroids: disease or drugs? De Vries, F. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. J.W.J. Lammers, dr. T.P. van Staa, dr. M. Bracke. Utrecht University (Faculty of Science), 15 Feb 2007. Read on Utrecht University Repository

Effects of CYP2C9 and VKORC1 polymorphisms and drug interactions on coumarin anticoagulation control Schalekamp, T. Supervisory team: prof. dr. A. de Boer. Utrecht University (Faculty of Science), 7 May 2007. Read on Utrecht University Repository

CYP2D6 and HTR2C polymorphisms in psychiatric pharmacotherapy Mulder, J. Supervisory team: prof. dr. A.C.G. Egberts, dr. F.W. Wilmink. Utrecht University (Faculty of Science), 2 Jul 2007. Read on Utrecht University Repository

The gastrointestinal and cardiovascular safety of COX-2 selective inhibitors in general practice: the contribution of prescription-event monitoring Layton, D. Supervisory team: prof. dr. A.C.G. Egberts. Utrecht University (Faculty of Science), 29 Oct 2007. Read on Utrecht University Repository

Drug effects on the risk and prognosis of community-acquired pneumonia Van de Garde, E.M.W. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. J.M.M. van den Bosch, dr. P.C. Souverein, dr. V.H.M. Deneer. Utrecht University (Faculty of Science), 21 Nov 2007. Read on Utrecht University Repository

Methods to adjust for confounding. Propensity scores and instrumental variables Martens, E.P. Supervisory team: prof. dr. A. de Boer, dr. O.H. Klungel, dr. W.R. Pestman. Utrecht University (Faculty of Science), 10 Dec 2007. Read on Utrecht University Repository

Pharmaceutical care in diabetes Storimans, M.J. Supervisory team: prof. dr. C.J. de Blaey, dr. H. Talsma, dr. O.H. Klungel. Utrecht University (Faculty of Science), 18 Jan 2006. Read on Utrecht University Repository

Prevention of cardiovascular diseases Van der Elst, M.E. Supervisory team: prof. dr. A. de Boer, prof. dr. C.J. de Blaey, dr. M.L. Bouvy. Utrecht University (Faculty of Science), 16 Feb 2006. Read on Utrecht University Repository

New drugs in general practice: prescribing patterns and external influences Florentinus, S.R. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. P.P. Groenewegen, dr. E.R. Heerdink, dr. ir. C.E.M.J. van Dijk. Utrecht University (Faculty of Science), 18 May 2006. Read on Utrecht University Repository

Clinical risk management in community pharmacy Buurma, H. Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. P.G.A.M. de Smet. Utrecht University (Faculty of Science), 4 Oct 2006. Read on Utrecht University Repository

Adherence and persistence with antihypertensive drugs Van Wijk, B.L.G. Supervisory team: prof. dr. A. de Boer, dr. O.H. Klungel, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 6 Dec 2006. Read on Utrecht University Repository

Antipsychotics in daily clinical practice: patterns, choices and consequences Hugenholtz, G.W.K. Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. W.A. Nolen, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 7 Dec 2005.

Molecular mechanisms of disease in hereditary red blood cell enzymopathies Van Wijk, H.A. Supervisory team: prof. dr. W.W. van Solinge, prof. dr. J.J.M. Marx, dr. G. Rijksen. Utrecht University (Faculty of Science), 9 Mar 2004. Read on Utrecht University Repository

Quality and safety aspects of lipid-lowering drug use Mantel-Teeuwisse, A.K. Supervisory team: prof. dr. A. de Boer, prof. dr. A.J.  Porsius, dr. O.H. Klungel, dr. W.M.M. Verschuren. Utrecht University (Faculty of Science), 26 May 2004.

Drug-induced arrhythmias, quantifying the problem De Bruin, M.L. Supervisory team: prof. dr. H.G.M. Leufkens, H.G.M,  prof. dr. A.W. Hoes. Utrecht University (Faculty of Science), 12 Dec 2004. Read on Utrecht University Repository

Transitions in migraine treatment: barriers and opportunities Rahimtoola, H. Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. H.G.M. Leufkens, dr. C.C. Tijssen. Utrecht University (Faculty of Science), 7 Apr 2003.

Pharmacoepidemiological studies with cancer as outcome Beiderbeck, A.B. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. B.H.Ch. Stricker, dr. M.C.J.M. Sturkenboom. Utrecht University (Faculty of Science), 2 Jun 2003.

Pharmacoepidemiological determinants of exacerbations of chronic obstructive lung diseases Gerrits, C.M.J.M. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. J.W.J. Lammers, dr. R.M.C. Herings. Utrecht University (Faculty of Science), 2 Sept 2003.

Pharmacogenetics of HMG-CoA reductase inhibitors Maitland-van der Zee, A.H. Supervisory team: prof. dr. A. de Boer, prof. dr. H.G.M. Leufkens, dr. O.H. Klungel. Utrecht University (Faculty of Science), 17 Sept 2003.

Quality of the pharmacological treatment of patients with Parkinson's disease Van de Vijver, D.A.M.C. Supervisory team: prof. dr. A.J. Porsius, prof. dr. R.A.C. Roos, Prof. Dr. A. de Boer. Utrecht University (Faculty of Science), 30 Jan 2002.

Drug-induces extrapyramidal syndromes Schillevoort, I.E.R.M. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. R.A.C. Roos, dr. R.M.C. Herings. Utrecht University (Faculty of Science), 28 Feb 2002.

Drug therapy in heart failure: studies on prescribing, drug induced problems and compliance Bouvy, M.L. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.W. Hoes, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 18 Mar 2002. Read on Utrecht University Repository

Assessment and diffusion of biotechnology drugs Zwart-van Rijkom, J.E.F. Supervisory team: prof. dr. A.W. Broekmans, prof. dr. F.F.H. Rutten. Utrecht University (Faculty of Science), 8 Apr 2002. Read on Utrecht University Repository

Pharmacotherapy in type 2 diabetes mellitus patients: beyond glycaemic control Erkens, J.A. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. D.E. Grobbee, dr. O.H. Klungel, dr. R.P. Stolk. Utrecht University (Faculty of Science), 21 May 2002.

The value of observational research on antidepressant use: a broadened perspective Meijer, W.E.E. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. W.A. Nolen, dr. E.R. Heerdink. Utrecht University (Faculty of Science), 16 Oct 2002.

Implementation of patient education in Dutch community pharmacies Pronk, M.C.M. Supervisory team: prof. dr. A. Bakker, prof. dr. E.M. Rogers, dr. A.T.G. Blom, dr. R. Jonkers. Utrecht University (Faculty of Science), 28 Oct 2002.

Detection and elucidation of adverse neuropsychiatric drug effects Movig, K.L.L. Supervisory team: prof. dr. A.C.G. Egberts, prof. dr. H.G.M. Leufkens. Utrecht University (Faculty of Science), 28 Nov 2002.

Drug effects in high-risk patients Souverein, P.C. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts. Utrecht University (Faculty of Science), 16 Dec 2002.

Effects of outreach strategies on quality of pharmacotherapy Van Eijk, M.E.C. Supervisory team: prof. dr. A.J. Porsius, dr. A. de Boer. Utrecht University (Faculty of Science), 19 Jun 2001. Read on Utrecht University Repository

Quantitative signal detection in pharmacovigilance Van Puijenbroek, E.P. Supervisory team: prof. dr. H.G.M. Leufkens, prof. dr. A.C.G. Egberts. Utrecht University (Faculty of Science), 1 Oct 2001.

Postmarketing Surveillance of Proton Pump Inhibitors in Perspective: The Case of Lansoprazole Bodewes-Claessens, A. Supervisory team: Prof. dr. H.G.M. Leufkens, prof. dr. C.B.H.W. Lamers, dr. E.R. Heerdink. Utrecht University (Faculty of Science),6 Nov 2000. Read on Utrecht University Repository

Pharmacoepidemiologic risk evaluation in bone diseases Van Staa, T.P. Supervisory team: prof. dr. H.G.M. Leufkens, dr. C. Cooper. Utrecht University (Faculty of Science), 9 Jun 1999.

Studies on the quality of the pharmacolgical treatment of hypertension in the general population: Differences between women and men Klungel, O.H. Supervisory team: Prof. dr. A. Bakker, dr. A. de Boer, dr. A.H.P. Paes, dr. ir. J.C. Seidell. Utrecht University (Faculty of Science), 4 Mar 1999.  

Blue Boy - why not? Studies of benzodiazepine use in a Dutch community Van Hulten, R.P. Supervisory team: prof. dr. A. Bakker, prof. dr. H.G.M. Leufkens, dr. K.B. Teeuw. Utrecht University (Faculty of Science), 1 Sept 1998.

Drug related problems in the elderly. Studies on occurrence and interventions Lau, H.S. Supervisory team: prof. dr. A.J. Porsius, dr. A. de Boer. Utrecht University (Faculty of Science), 2 Dec 1998.

Pharmacoepidemiologic approaches to the evaluation of antidepressant drugs Egberts, A.C.G. Supervisory team: prof. dr. A. Bakker, prof. dr. H.G.M. Leufkens, dr. G.H.P. de Koning. Utrecht University (Faculty of Science), 8 Oct 1997.

Developing patient education in community pharmacy. Blom, A.T.G. Supervisory team: Prof. dr. A. Bakker, prof. dr. G.J. Kok, dr. R. Jonkers Utrecht University (Faculty of Science), 7 Feb 1996.

Clustering of drug use in the elderly: population based studies into prevalence and outcomes Heerdink, E.R. Supervisory team: Prof. dr. A. Bakker, prof. dr. J. Glerum, dr. H.G.M. Leufkens. Utrecht University (Faculty of Science), 9 Oct 1995.

A Regionalized Spontaneous Surveillance Program for Adverse Drug Reactions as a Tool to Improve Pharmacotherapy De Koning, G.H.P. Supervisory team: Prof. dr. A. Bakker, prof. dr A.J. Porsius, dr. A. van der Kuy. Utrecht University (Faculty of Science), 24 Mar 1994.

PHARMO A record linkage system for postmarketing surveillance of prescription drugs in The Netherlands Herings, R.M.C. Supervisory team: Prof. dr. A. Bakker, prof. dr. F. Sturmans, dr. B.H.Ch. Stricker. Utrecht University (Faculty of Science), 16 Jun 1993

Altered vascular reactivity in hypertension and atherosclerosis. The role of the endothelium Riezebos, J. Supervisory team: Prof. dr. A.J. Porsius, dr. J. Wemer. Utrecht University (Faculty of Science), 9 Nov 1992.

Pharmacy records in Pharmacoepidemiology. Studies on antiinflammatory and antirheumatic drugs Leufkens, H.G.M. Supervisory team: Prof. dr. A. Bakker, dr. Y.A. Hekster. Utrecht University (Faculty of Science), 18 Oct 1990.

Apotheker en artsen in overleg? Paes, A.H.P. Supervisory team: Prof. dr. F.A. Nelemans, prof. dr. A. Bakker Utrecht University (Faculty of Science), 25 Apr 1989.

Utrecht University Heidelberglaan 8 3584 CS Utrecht The Netherlands Tel. +31 (0)30 253 35 50

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Veliky Novgorod city, Russia

The capital city of Novgorod oblast .

Veliky Novgorod - Overview

Veliky Novgorod or Novgorod the Great (just Novgorod until 1999) is a city in the north-west of Russia, the administrative center of Novgorod Oblast. It is one of the oldest and most famous cities in Russia with more than a thousand years of history.

The population of Veliky Novgorod is about 224,800 (2022), the area - 90 sq. km.

The phone code - +7 8162, the postal codes - 173000-173902.

Novgorod city flag

Novgorod city coat of arms.

Novgorod city map, Russia

Novgorod city latest news and posts from our blog:.

7 January, 2022 / Nikolai Bugrov's Summer Dacha in Volodarsk .

27 September, 2020 / The Nikolo-Vyazhischi Convent near Veliky Novgorod .

30 August, 2020 / Staraya Russa - one of the oldest Russian towns .

31 March, 2019 / Vitoslavlitsy Museum of Folk Architecture .

28 January, 2019 / Veliky Novgorod Kremlin .

More posts..

History of Veliky Novgorod

Foundation of novgorod and the novgorod republic.

The official founding year of Novgorod is 859, when it was first mentioned in the chronicle. In 862, the so-called “vocation of the Varangians” led by Rurik took place on Novgorod land, which was the beginning of the formation of the Old Russian state. In 882, after the death of Rurik, Prince Oleg became the ruler of Novgorod. He captured Kiev and moved the capital of the state to it. It was the beginning of the Kievan Rus state.

Novgorod was the second town of the Kievan Rus by cultural, economic, and political influence. In 1045-1050, the Cathedral of St. Sophia was built - the main Orthodox church of Novgorod and one of the oldest preserved stone churches in Russia.

The convenient location of Novgorod at the intersection of trade routes “from the Varangians to the Greeks” made it the largest center of intra-Russian and international trade. Constant contacts of the town with the island of Gotland, German towns and the Hansa led to the opening of the first foreign missions on the territory of Novgorod.

The first attempts of Novgorod to gain independence from the Kievan Rus were taken in the 11th century. Novgorod boyars, with the support of the local population, wanted to get rid of the burden of Kiev taxation and to create their own army. In 1136, due to the retreat of Prince Vsevolod Mstislavovitch from the battlefield at Zhdanaya mountain, he was exiled from Novgorod, and a republican government was established in the region.

From 1136 to 1478, Novgorod was the capital of the Russian medieval state known as the Novgorod Republic. In the 12th century, the Novgorod land included part of the Baltic, part of Karelia, the southern part of Finland, the southern coast of Lake Ladoga, the banks of the Northern Dvina River, and vast areas of the European north up to the Urals.

More Historical Facts…

During the Mongol invasion of Rus, Novgorod avoided destruction due to its remote location. It was the only old Russian town that avoided decline in the 11th-12th centuries. In 1259, with the support of Prince Alexander Nevsky, the Mongols conducted a census in Novgorod to collect tribute. In 1280, in Novgorod, a document was drawn up known as “Russian Truth” - the very first set of laws in Russia. Until the 15th century, Novgorod’s possessions expanded to the east and northeast.

Areas northeast of Novgorod were rich in fur-bearing animals and salt. These resources were of great importance for the economy of the Novgorod Republic, which was based on trade. The town was part of the trade route from Scandinavia to Byzantium. The Russian folk hero Sadko was a merchant from Novgorod.

The Novgorod Republic was characterized by some features of the social system and feudal relations: a significant social and landowning weight of the Novgorod boyars and their active participation in trade and other activities. The main economic factor was not land, but capital. This led to a special social structure of society and an unusual form of government for medieval Rus.

The veche - a gathering of a part of the male population of the town - had broad powers. It invited, judged and expelled Novgorod princes; elected the mayor and the military leader; resolved issues of war and peace; passed and repealed laws; set the size of taxes and duties; elected representatives of the authorities in the Novgorod lands and tried them.

From the 14th century, the Tver and Moscow principalities, and the Grand Duchy of Lithuania attempted to subdue the Novgorod Republic. In 1470, Novgorod people asked the Metropolitan of Kiev to appoint a bishop for them (Kiev belonged to the Grand Duchy of Lithuania at that time). After it, Ivan III, the Grand Prince of Moscow, accused them of treason. In 1471, he announced a military campaign against Novgorod. Moscow troops defeated Novgorod militia during the battle on the Shelon River and took the town.

In 1478, after a series of wars against Moscow, Novgorod lost its independence and the Novgorod Republic ceased to exist. The veche was abolished, the veche bell was taken to Moscow; power in the town was granted to the governors appointed by the Grand Prince of Moscow. A lot of boyar families were expelled from Novgorod.

Novgorod in the 16th-19th centuries

The oprichnina pogrom perpetrated in the winter of 1569/1570 by the army personally headed by Ivan the Terrible inflicted enormous damage on Novgorod. The reason for the pogrom was a denunciation and suspicion of treason. The town was plundered, the property of churches, monasteries and merchants was confiscated, thousands of residents were killed. In 1571, the population of Novgorod was about 5,000 people.

From 1611 to 1617, during the Time of Troubles, Novgorod was occupied by the Swedes. After the occupation, half of the town was burnt down. The population decreased to only about 500 residents. Nikon (the most famous Russian Patriarch) was the metropolitan of Novgorod in 1648-1652.

In 1700, the Great Northern War began. After the defeat at Narva, Peter I hastily prepared the fortifications of Novgorod for a possible siege of the Swedes. Swedish troops did not reach Novgorod; nevertheless, the Novgorod regiment played an important role in the Battle of Poltava in 1709.

In 1703, in connection with the founding of St. Petersburg, the new capital of Russia, a lot of craftsmen from Novgorod were involved in its construction. At the same time, Novgorod finally lost its former importance as a trade center and turned into an ordinary provincial town. In 1727, a separate Novgorod Governorate was formed with its center in Novgorod.

In the first half of the 19th century, Novgorod became the center of military settlements. At the same time, there was almost no industrial production in the town. In 1841-1842, the writer Alexander Herzen was in exile in Novgorod.

One of the brightest pages in the history of Veliky Novgorod in the 19th century was the celebration of the 1000th anniversary of the Russian state in 1862. In honor of this event, a monument to the Millennium of Russia was erected in the center of the Novgorod Kremlin. In 1875, 17,384 people lived in Novgorod, along with military units. 12 small enterprises employed only 63 workers.

Novgorod in the 20th century

Despite the increased interest in its history, Novgorod both at the end of the 19th century and at the beginning of the 20th century remained a typical provincial town of the Russian Empire, despite its status as a regional capital. In 1914, the population of Novgorod was about 28,200 people.

In 1927, as a result of the administrative-territorial reform carried out in the USSR, the Novgorod Governorate became part of Leningrad Oblast. The Leningrad leadership viewed the Novgorod land as a rural region. No industrialization was planned.

From August 15, 1941 to January 20, 1944, during the Second World War, Novgorod was occupied by German and Spanish troops (“The Blue Division”). The war caused huge and in many ways irreparable damage to the monuments of the city itself and its environs. All wooden buildings burned down. The most valuable collections of archeology, history and art were plundered from the Novgorod museum, which was not completely evacuated in time. Almost the entire city infrastructure and industrial enterprises were destroyed, world famous monuments of Novgorod architecture were turned into ruins.

On July 5, 1944, Novgorod Oblast was formed. The transformation of Novgorod into the administrative and economic center of a separate region had a beneficial effect on the acceleration of its restoration. On November 1, 1945, Novgorod was included in the list of 15 Soviet cities subject to priority restoration. In addition, a special decree was issued on the restoration of architectural monuments. One of the first to be restored was the Millennium of Russia monument.

In the post-war years, the presence of large undeveloped areas and wastelands after the dismantling of the rubble of destroyed buildings in the city center made it possible to begin extensive archaeological research. The results of these studies were numerous finds of objects of old Russian art and everyday life. One of the most important finds was the discovery of the first birch bark letter on July 26, 1951. Archaeological research continues to this day.

In the 1950s-1970s, the main restoration work of architectural monuments was carried out. Novgorod became known as the center of all-Union and international tourism. In 1964, not far from the old Yuryev Monastery on the shore of Lake Myachino, the creation of the Vitoslavlitsy Museum of Folk Wooden Architecture began. In 1967, the population of the city was about 107,000 people.

In 1992, 37 unique monuments of old Russian culture in Novgorod were included in the UNESCO World Cultural Heritage List. The population of the city reached its maximum and amounted to 235 thousand people.

On June 11, 1999, the President of the Russian Federation Boris Yeltsin signed the federal law “On renaming the city of Novgorod, the administrative center of Novgorod Oblast, into the city of Veliky Novgorod.” Also in the 1990s, a lot of streets in the city center received their historical names back.

Monuments of Veliky Novgorod

Victory Monument in Veliky Novgorod

Author: Sergey Duhanin

Light tank T-70 in Veliky Novgorod

Author: Konstantin Matekhin

Monument to the Millennium of Russia in Veliky Novgorod

Veliky Novgorod - Features

Veliky Novgorod is deservedly called “the father of Russian cities”. In this place the Russian statehood was born. The city stands on the banks of the Volkhov River, 6 km from Lake Ilmen, 575 km north-west of Moscow and 190 km south-east of St. Petersburg. Due to similar names, Veliky Novgorod is often confused with Nizhny Novgorod. And this applies not only to foreigners, but also to residents of Russia.

The Volkhov River divides the city into two parts: Sofia and Torgovaya (Trade) sides. The Sofia side got its name from the Sofia Cathedral, which is about one thousand years old. The main part of the city is located here, including the Novgorod Kremlin and the historic center, as well as new districts.

In the old days, there was a large market on the Trade side - Torg. Today, it is built up mainly with private houses. The Yaroslav’s Courtyard is also located here. It is a historical and architectural complex on the site where the residence of Yaroslav the Wise (Prince of Novgorod in 988-1015) used to be.

The climate of Veliky Novgorod is moderately continental, with cold snowy winters and moderately warm summers. The average temperature in January is minus 9.2 degrees Celsius, in July - plus 17.3 degrees Celsius.

Novgorod Oblast has a unique transport and geographical position. The main highway, rail, air, and water transport routes connecting St. Petersburg and Moscow pass through its territory. Public transport in the city is represented by buses, trolleybuses.

The region’s largest employer is the chemical fertilizer plant “Acron”, which produces ammonia, saltpeter, nitric acid, and other substances. This enterprise is one of the world’s largest fertilizer producers. The plant in Veliky Novgorod employs about 5 thousand people.

Tourism is gradually becoming more and more important in the city’s economy. Veliky Novgorod is rightly called the city-museum of Old Rus. No other city in Russia has so many remarkable architectural monuments and monumental paintings of the 11th-17th centuries. The architecture of Veliky Novgorod is unique because a lot of old churches have survived here. A significant part of them were erected in the period from the 11th to the 16th centuries. In some churches, old wall paintings have been preserved, which are of great cultural value.

The main discovery made on the territory of Veliky Novgorod is more than 1,000 preserved birch bark letters of various contents written in the 11th-15th centuries. These include business letters, love letters, recipe notes, Bible commentaries, commercial calculations, and even student scribbles.

Main Attractions of Veliky Novgorod

Novgorod Detinets (Kremlin) - the fortress of Veliky Novgorod located on the left bank of the Volkhov River, the oldest preserved kremlin in Russia and the most northern one. The first mention of it in chronicles dates back to 1044. It is an architectural monument of federal significance. Novgorod Detinets as part of the historic center of Veliky Novgorod is included in the UNESCO World Heritage List.

The construction of the stone fortress was completed by the end of the 15th century. About 1.5 kilometers of fortress walls, nine towers, and old churches have survived to this day. A road going through the Novgorod Kremlin leads to the bridge connecting the Sofia and Torgovaya sides of the city. The 41-meter watchtower known as “Kokuy” offers a great view of the entire city and its surroundings.

Today, it is the cultural and tourist center of Veliky Novgorod. Here you can find the main expositions of the Novgorod Museum-Reserve (the exposition of the Old Russian arts and crafts and jewelry in the Chamber of Facets; “History of the Novgorod Region”, “Old Russian icon painting”, “Russian art of the 18th-20th centuries”), restoration workshops, a library, philharmonic society, college of arts, and a music school. The Novgorod Kremlin is surrounded by a spacious park. A walk from the railway station to the Novgorod Kremlin takes about 20 minutes.

Saint Sophia Cathedral (1045-1050) - the main Orthodox church in Veliky Novgorod located on the territory of the Novgorod Kremlin, one of the oldest churches in Russia. Churches of this type were built in Rus only in the 11th century. Sophia Cathedral was built in the Byzantine style, has a pyramidal structure and 6 domes. This is one of the symbols of Veliky Novgorod.

The belfry of St. Sophia Cathedral rises above the Novgorod Kremlin in the form of a wall with five spans in the upper part. This type of structure was invented during the reign of the Novgorod Archbishop Euthymius II and then repeated in Russia only twice.

Monument to the Millennium of Russia (1862) - a magnificent monument more than 15 meters high erected opposite the St. Sophia Cathedral in honor of the millennium anniversary of the legendary vocation of the Varangians to Rus. The monument consists of 128 figures. At the very top you can see an angel - the personification of Orthodoxy and a woman depicting Rus, below - princes, church hierarchs and enlighteners, who took part in important historical events that happened over the thousand-year history of Russia.

Yaroslav’s Courtyard and Torg - an architectural complex located opposite the Novgorod Kremlin, on the other bank of the Volkhov River. Both banks are connected by a pedestrian bridge. Several monuments of the 12th-16th centuries have survived on its territory, including the Nikolsky Cathedral (1113) and the Church of Paraskeva Pyatnitsa (the 13th century). The place was named after Prince Yaroslav the Wise. In old times, fairs were held here. The most recent construction is the arcade of the Gostiny Dvor, which consists of several dozen white-stone arches.

St. George’s (Yuriev) Monastery . Founded in 1030, it is one of the oldest monasteries in Russia, a cultural heritage site of federal significance. The monastery is located on the southern outskirts of Veliky Novgorod on the bank of the Volkhov River. On the territory of the monastery there are St. George, Spassky, and Holy Cross Cathedrals, a four-tiered bell tower 52 m high, and several old churches. Crowned with three silvery domes, St. George’s Cathedral is a wonderful example of Old Russian architecture. The Vitoslavlitsy Museum is located nearby. Yur’yevskoye Highway, 10.

Museum of Folk Wooden Architecture “Vitoslavlitsy” . This open-air exhibition was opened in 1964. 22 wooden architectural monuments of the 16th-20th centuries - churches, residential buildings, and outbuildings - were brought here from different districts of the Novgorod region.

Inside the peasant huts, you can see recreated old interiors: “Winter Life”, “Wedding”, “Wool Felting Craft”, and others. Folk festivals are also held on the territory of the museum. On the second floor of the souvenir shop there is the Museum of Irons with a unique collection of irons of the 18th-20th centuries. Yur’yevskoye Highway, 14.

Center for Musical Antiquities named after V.I. Povetkin . The unique collection of this museum acquaints visitors with the old musical instruments of Rus. Here you can also hear old Russian music. Most of the exhibits date back to the 10th-15th centuries. For the guests of the center, folk songs of the Russian North-West and North are performed. Choir concerts are held on holidays. Il’ina Street, 9b.

Art Museum . The permanent exhibition of this museum is dedicated to Russian art of the 17th-20th centuries. It was opened in the historic building of the Noble Assembly in 2001. The rich collection of the museum includes paintings, drawings, sculptures, miniatures, etc.

Among the most valuable exhibits are paintings created by such masters as K. Bryullov, I. Repin, A. Aivazovsky and sculptures, including M. Antokolsky and M. Vrubel. The museum’s collection of Russian art objects is considered one of the best outside Moscow and St. Petersburg. Sofiyskaya Square, 2.

Museum of Artistic Culture of the Novgorod Land . This museum was opened in one of the buildings of the Desyatinnyy monastery in 2002. The exposition is composed of works by Novgorod artists of the late 20th - early 21st centuries. In addition to paintings, visitors can look at porcelain and glass products made by local craftsmen. Desyatinnyy Lane, 6.

Novgorod city of Russia photos

Pictures of veliky novgorod.

Veliky Novgorod architecture

Author: Elena Abramova

Veliky Novgorod Detinets (Kremlin)

Author: Ismail Soytekinoglu

Veliky Novgorod Fortress

Picturesque churches of Veliky Novgorod

St. Sophia Cathedral in Veliky Novgorod

Author: Zaritsky Igor

Peter and Paul Church in Veliky Novgorod

Church of Clement, Pope of Rome in Veliky Novgorod

Old churches of Veliky Novgorod

Church of the Transfiguration on Ilyin in Veliky Novgorod

Author: Sergey Popov

Myrrhbearers Church in Veliky Novgorod

The questions of our visitors

There are several ways of going from the airport of St. Petersburg to Veliky Novgorod.

The fastest one and of course the most expensive is to go by taxi from the airport straight to the destination city. The price is about 4,500-5,000 Rubles (about 70-80 USD).

Another way is to go by train. From the airport you should go to Vitebsky railway station, departure: 7:53, arrival: 13:06 local time. Also you can go to Moskovsky railway station. There are two trains: the first one departs at 8:12 and the second one - at 17:18). Not sure about the price of the tickets but much cheaper than going by taxi.

The third variant is to go by bus. You should go to the bus station at Obvodnoy Canal Embankment. The first bus departs at 7:30; the latest - at 21:30.

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