Synthesis of aspirin
Written by J.A Dobado | Last Updated on November 12, 2024
Objective of Aspirin Synthesis: Purpose and Application
Historical and scientific background of aspirin synthesis.
Acetylsalicylic acid is marketed under the name of aspirin for the home Bayer being one of the drugs most consumed in the world. It was synthesized at the end of the last century by the German chemist Felix Hofmann .
It is a drug that is found in the list of essential medicines of the WHO . Acts as antipyretic, and mainly as an analgesic. As antipyretic exerts its effect on two levels: it increases the heat dissipation by vaso-dilation (action not significant), and acts on the thermostat hypothalamic, which is the central regulator of the body’s temperature.
Reaction Mechanism in Aspirin Synthesis: Step-by-Step
The reaction is catalyzed by acid (phosphoric acid, H 3 PO 4 ). In a first step occurs the protonation of acetic anhydride as shown in the figure.
In a third step happens a removal: producing acetic acid and acetyl salicylic acid protonated. The fourth and last step it is a deprotonation by the effect of the water that is added at the end of the reaction.
Experimental Procedure for Aspirin Synthesis in the Laboratory
The flask is cooled in an ice bath, with what the product should begin to crystallize. Vacuum filter and calculate the performance of the dry product (performance estimated 70 % and melting point 134-136 ° C).
Physico-Chemical Properties of Aspirin: Key Characteristics
Ghs pictograms, international chemical identifier.
The IUPAC InChI key identifiers for the main compounds used in this experiment are provided to facilitate the nomenclature and formulation of chemical compounds and the search for information on the Internet for these compounds.
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Learn how to synthesize aspirin (acetylsalicylic acid) from salicylic acid and acetic anhydride in a laboratory experiment. Follow the reaction mechanism, the experimental procedure, and the physico-chemical properties of the compounds involved.
Learn how to make acetylsalicylic acid (aspirin) by reacting salicylic acid with acetic anhydride in the presence of sulfuric acid. Find out how to purify, identify and calculate the yield of your product.
Esterification: The Synthesis of Aspirin (ASA) Introduction . Most of us are familiar with esters, but are not aware of their presence in our everyday life. Methyl salicylate, for example, is oil of wintergreen, isopentenyl acetate is oil of banana or pear, butyl butanoate smells like pineapple, propyl-2-methylpropanoate smells like rum and p-
Learn how to synthesize acetylsalicylic acid (ASA, aspirin) from salicylic acid and acetic anhydride, and how to analyze its purity by melting point, Fe3+-SA test, and TLC. This is a 2-week experiment for undergraduate chemistry students at UCI.
Learn how to make aspirin from acetic anhydride and salicylic acid using phosphoric acid as a catalyst. Follow the experimental procedure, record the data, and calculate the percent yield of the reaction.
Synthesis of Aspirin Synthesis Purification Characterization. Aspirin: some background! Patented by Bayer in 1893! One of the oldest drugs! One of the most consumed drugs (Production in the US is 10 million Kg/year) Aspirin: Biological activity! Analgesic (painkiller)! Antipyretic (fever reducer)!
Learn how to synthesize aspirin from acetic anhydride and salicylic acid, and how to calculate the limiting reagent and percent yield. Perform recrystallization to purify the product and determine its melting point.
Learn how to prepare aspirin from salicylic acid and acetic anhydride in a simple reaction. Test the purity of your product using melting point, TLC and FeCl3 tests.
Learn how to synthesize aspirin from salicylic acid and acetic anhydride using a simple procedure and equation. Find out the history, mechanism, and applications of aspirin as a medication.
Microscale synthesis of aspirin - teacher notes Handout | PDF, Size 0.19 mb; Download all. Additional information. This resource is part of our Microscale chemistry collection, which brings together smaller-scale experiments to engage your students and explore key chemical ideas.